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Drug Delivery Systems on Leprosy Therapy: Moving Towards Eradication?
Leprosy disease remains an important public health issue as it is still endemic in several countries. Mycobacterium leprae, the causative agent of leprosy, presents tropism for cells of the reticuloendothelial and peripheral nervous system. Current multidrug therapy consists of clofazimine, dapsone...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763250/ https://www.ncbi.nlm.nih.gov/pubmed/33322356 http://dx.doi.org/10.3390/pharmaceutics12121202 |
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author | Chaves, Luíse L. Patriota, Yuri Soares-Sobrinho, José L. Vieira, Alexandre C. C. Lima, Sofia A. Costa Reis, Salette |
author_facet | Chaves, Luíse L. Patriota, Yuri Soares-Sobrinho, José L. Vieira, Alexandre C. C. Lima, Sofia A. Costa Reis, Salette |
author_sort | Chaves, Luíse L. |
collection | PubMed |
description | Leprosy disease remains an important public health issue as it is still endemic in several countries. Mycobacterium leprae, the causative agent of leprosy, presents tropism for cells of the reticuloendothelial and peripheral nervous system. Current multidrug therapy consists of clofazimine, dapsone and rifampicin. Despite significant improvements in leprosy treatment, in most programs, successful completion of the therapy is still sub-optimal. Drug resistance has emerged in some countries. This review discusses the status of leprosy disease worldwide, providing information regarding infectious agents, clinical manifestations, diagnosis, actual treatment and future perspectives and strategies on targets for an efficient targeted delivery therapy. |
format | Online Article Text |
id | pubmed-7763250 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77632502020-12-27 Drug Delivery Systems on Leprosy Therapy: Moving Towards Eradication? Chaves, Luíse L. Patriota, Yuri Soares-Sobrinho, José L. Vieira, Alexandre C. C. Lima, Sofia A. Costa Reis, Salette Pharmaceutics Review Leprosy disease remains an important public health issue as it is still endemic in several countries. Mycobacterium leprae, the causative agent of leprosy, presents tropism for cells of the reticuloendothelial and peripheral nervous system. Current multidrug therapy consists of clofazimine, dapsone and rifampicin. Despite significant improvements in leprosy treatment, in most programs, successful completion of the therapy is still sub-optimal. Drug resistance has emerged in some countries. This review discusses the status of leprosy disease worldwide, providing information regarding infectious agents, clinical manifestations, diagnosis, actual treatment and future perspectives and strategies on targets for an efficient targeted delivery therapy. MDPI 2020-12-11 /pmc/articles/PMC7763250/ /pubmed/33322356 http://dx.doi.org/10.3390/pharmaceutics12121202 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chaves, Luíse L. Patriota, Yuri Soares-Sobrinho, José L. Vieira, Alexandre C. C. Lima, Sofia A. Costa Reis, Salette Drug Delivery Systems on Leprosy Therapy: Moving Towards Eradication? |
title | Drug Delivery Systems on Leprosy Therapy: Moving Towards Eradication? |
title_full | Drug Delivery Systems on Leprosy Therapy: Moving Towards Eradication? |
title_fullStr | Drug Delivery Systems on Leprosy Therapy: Moving Towards Eradication? |
title_full_unstemmed | Drug Delivery Systems on Leprosy Therapy: Moving Towards Eradication? |
title_short | Drug Delivery Systems on Leprosy Therapy: Moving Towards Eradication? |
title_sort | drug delivery systems on leprosy therapy: moving towards eradication? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763250/ https://www.ncbi.nlm.nih.gov/pubmed/33322356 http://dx.doi.org/10.3390/pharmaceutics12121202 |
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