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Etiology and Outcome of Acute Liver Failure in Children—The Experience of a Single Tertiary Care Hospital from Romania

Background: Acute liver failure (ALF) is a rare disease, associated with high mortality, despite optimal medical therapy without emergency liver transplantation. Knowing the possible cause of ALF plays a vital role in the management, as the child could benefit from effective specific therapies in em...

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Autores principales: Grama, Alina, Aldea, Cornel Olimpiu, Burac, Lucia, Delean, Dan, Bulata, Bogdan, Sirbe, Claudia, Duca, Emanuela, Boghitoiu, Dora, Coroleuca, Alexandra, Pop, Tudor Lucian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763257/
https://www.ncbi.nlm.nih.gov/pubmed/33317098
http://dx.doi.org/10.3390/children7120282
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author Grama, Alina
Aldea, Cornel Olimpiu
Burac, Lucia
Delean, Dan
Bulata, Bogdan
Sirbe, Claudia
Duca, Emanuela
Boghitoiu, Dora
Coroleuca, Alexandra
Pop, Tudor Lucian
author_facet Grama, Alina
Aldea, Cornel Olimpiu
Burac, Lucia
Delean, Dan
Bulata, Bogdan
Sirbe, Claudia
Duca, Emanuela
Boghitoiu, Dora
Coroleuca, Alexandra
Pop, Tudor Lucian
author_sort Grama, Alina
collection PubMed
description Background: Acute liver failure (ALF) is a rare disease, associated with high mortality, despite optimal medical therapy without emergency liver transplantation. Knowing the possible cause of ALF plays a vital role in the management, as the child could benefit from effective specific therapies in emergencies. Methods: We have analyzed the etiology and outcome of ALF in children followed-up in a tertiary care hospital between January 2012–December 2018. The patients were grouped into different age categories: neonates (0–1 month), infants (1–12 months), children (1–14 years), and teenagers (14–18 years). Results: 97 children (46 males, 47.42%, the mean age of 7.66 ± 8.18 years) were admitted with ALF. The most important causes of ALF were in neonates and infants, infections (72.72%), and metabolic disorders (43.47%), in children and adolescents were the toxic causes (60% and 79.41%). The mortality rate was 31.95% (31 patients), mainly in ALF due to infections or metabolic disorders. Conclusions: In neonates and infants, the main causes of ALF were infections and metabolic diseases, while in older children and teenagers, were toxin-induced liver injuries. The mortality among neonates and infants was significantly higher than in other ages. Early recognition and immediate therapeutic intervention could improve the outcome of these patients.
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spelling pubmed-77632572020-12-27 Etiology and Outcome of Acute Liver Failure in Children—The Experience of a Single Tertiary Care Hospital from Romania Grama, Alina Aldea, Cornel Olimpiu Burac, Lucia Delean, Dan Bulata, Bogdan Sirbe, Claudia Duca, Emanuela Boghitoiu, Dora Coroleuca, Alexandra Pop, Tudor Lucian Children (Basel) Article Background: Acute liver failure (ALF) is a rare disease, associated with high mortality, despite optimal medical therapy without emergency liver transplantation. Knowing the possible cause of ALF plays a vital role in the management, as the child could benefit from effective specific therapies in emergencies. Methods: We have analyzed the etiology and outcome of ALF in children followed-up in a tertiary care hospital between January 2012–December 2018. The patients were grouped into different age categories: neonates (0–1 month), infants (1–12 months), children (1–14 years), and teenagers (14–18 years). Results: 97 children (46 males, 47.42%, the mean age of 7.66 ± 8.18 years) were admitted with ALF. The most important causes of ALF were in neonates and infants, infections (72.72%), and metabolic disorders (43.47%), in children and adolescents were the toxic causes (60% and 79.41%). The mortality rate was 31.95% (31 patients), mainly in ALF due to infections or metabolic disorders. Conclusions: In neonates and infants, the main causes of ALF were infections and metabolic diseases, while in older children and teenagers, were toxin-induced liver injuries. The mortality among neonates and infants was significantly higher than in other ages. Early recognition and immediate therapeutic intervention could improve the outcome of these patients. MDPI 2020-12-09 /pmc/articles/PMC7763257/ /pubmed/33317098 http://dx.doi.org/10.3390/children7120282 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Grama, Alina
Aldea, Cornel Olimpiu
Burac, Lucia
Delean, Dan
Bulata, Bogdan
Sirbe, Claudia
Duca, Emanuela
Boghitoiu, Dora
Coroleuca, Alexandra
Pop, Tudor Lucian
Etiology and Outcome of Acute Liver Failure in Children—The Experience of a Single Tertiary Care Hospital from Romania
title Etiology and Outcome of Acute Liver Failure in Children—The Experience of a Single Tertiary Care Hospital from Romania
title_full Etiology and Outcome of Acute Liver Failure in Children—The Experience of a Single Tertiary Care Hospital from Romania
title_fullStr Etiology and Outcome of Acute Liver Failure in Children—The Experience of a Single Tertiary Care Hospital from Romania
title_full_unstemmed Etiology and Outcome of Acute Liver Failure in Children—The Experience of a Single Tertiary Care Hospital from Romania
title_short Etiology and Outcome of Acute Liver Failure in Children—The Experience of a Single Tertiary Care Hospital from Romania
title_sort etiology and outcome of acute liver failure in children—the experience of a single tertiary care hospital from romania
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763257/
https://www.ncbi.nlm.nih.gov/pubmed/33317098
http://dx.doi.org/10.3390/children7120282
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