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Etiology and Outcome of Acute Liver Failure in Children—The Experience of a Single Tertiary Care Hospital from Romania
Background: Acute liver failure (ALF) is a rare disease, associated with high mortality, despite optimal medical therapy without emergency liver transplantation. Knowing the possible cause of ALF plays a vital role in the management, as the child could benefit from effective specific therapies in em...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763257/ https://www.ncbi.nlm.nih.gov/pubmed/33317098 http://dx.doi.org/10.3390/children7120282 |
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author | Grama, Alina Aldea, Cornel Olimpiu Burac, Lucia Delean, Dan Bulata, Bogdan Sirbe, Claudia Duca, Emanuela Boghitoiu, Dora Coroleuca, Alexandra Pop, Tudor Lucian |
author_facet | Grama, Alina Aldea, Cornel Olimpiu Burac, Lucia Delean, Dan Bulata, Bogdan Sirbe, Claudia Duca, Emanuela Boghitoiu, Dora Coroleuca, Alexandra Pop, Tudor Lucian |
author_sort | Grama, Alina |
collection | PubMed |
description | Background: Acute liver failure (ALF) is a rare disease, associated with high mortality, despite optimal medical therapy without emergency liver transplantation. Knowing the possible cause of ALF plays a vital role in the management, as the child could benefit from effective specific therapies in emergencies. Methods: We have analyzed the etiology and outcome of ALF in children followed-up in a tertiary care hospital between January 2012–December 2018. The patients were grouped into different age categories: neonates (0–1 month), infants (1–12 months), children (1–14 years), and teenagers (14–18 years). Results: 97 children (46 males, 47.42%, the mean age of 7.66 ± 8.18 years) were admitted with ALF. The most important causes of ALF were in neonates and infants, infections (72.72%), and metabolic disorders (43.47%), in children and adolescents were the toxic causes (60% and 79.41%). The mortality rate was 31.95% (31 patients), mainly in ALF due to infections or metabolic disorders. Conclusions: In neonates and infants, the main causes of ALF were infections and metabolic diseases, while in older children and teenagers, were toxin-induced liver injuries. The mortality among neonates and infants was significantly higher than in other ages. Early recognition and immediate therapeutic intervention could improve the outcome of these patients. |
format | Online Article Text |
id | pubmed-7763257 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77632572020-12-27 Etiology and Outcome of Acute Liver Failure in Children—The Experience of a Single Tertiary Care Hospital from Romania Grama, Alina Aldea, Cornel Olimpiu Burac, Lucia Delean, Dan Bulata, Bogdan Sirbe, Claudia Duca, Emanuela Boghitoiu, Dora Coroleuca, Alexandra Pop, Tudor Lucian Children (Basel) Article Background: Acute liver failure (ALF) is a rare disease, associated with high mortality, despite optimal medical therapy without emergency liver transplantation. Knowing the possible cause of ALF plays a vital role in the management, as the child could benefit from effective specific therapies in emergencies. Methods: We have analyzed the etiology and outcome of ALF in children followed-up in a tertiary care hospital between January 2012–December 2018. The patients were grouped into different age categories: neonates (0–1 month), infants (1–12 months), children (1–14 years), and teenagers (14–18 years). Results: 97 children (46 males, 47.42%, the mean age of 7.66 ± 8.18 years) were admitted with ALF. The most important causes of ALF were in neonates and infants, infections (72.72%), and metabolic disorders (43.47%), in children and adolescents were the toxic causes (60% and 79.41%). The mortality rate was 31.95% (31 patients), mainly in ALF due to infections or metabolic disorders. Conclusions: In neonates and infants, the main causes of ALF were infections and metabolic diseases, while in older children and teenagers, were toxin-induced liver injuries. The mortality among neonates and infants was significantly higher than in other ages. Early recognition and immediate therapeutic intervention could improve the outcome of these patients. MDPI 2020-12-09 /pmc/articles/PMC7763257/ /pubmed/33317098 http://dx.doi.org/10.3390/children7120282 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Grama, Alina Aldea, Cornel Olimpiu Burac, Lucia Delean, Dan Bulata, Bogdan Sirbe, Claudia Duca, Emanuela Boghitoiu, Dora Coroleuca, Alexandra Pop, Tudor Lucian Etiology and Outcome of Acute Liver Failure in Children—The Experience of a Single Tertiary Care Hospital from Romania |
title | Etiology and Outcome of Acute Liver Failure in Children—The Experience of a Single Tertiary Care Hospital from Romania |
title_full | Etiology and Outcome of Acute Liver Failure in Children—The Experience of a Single Tertiary Care Hospital from Romania |
title_fullStr | Etiology and Outcome of Acute Liver Failure in Children—The Experience of a Single Tertiary Care Hospital from Romania |
title_full_unstemmed | Etiology and Outcome of Acute Liver Failure in Children—The Experience of a Single Tertiary Care Hospital from Romania |
title_short | Etiology and Outcome of Acute Liver Failure in Children—The Experience of a Single Tertiary Care Hospital from Romania |
title_sort | etiology and outcome of acute liver failure in children—the experience of a single tertiary care hospital from romania |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763257/ https://www.ncbi.nlm.nih.gov/pubmed/33317098 http://dx.doi.org/10.3390/children7120282 |
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