Single‐Cell Transcriptomics of Engineered Cardiac Tissues From Patient‐Specific Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Abnormal Developmental Trajectory and Intrinsic Contractile Defects in Hypoplastic Right Heart Syndrome

BACKGROUND: To understand the intrinsic cardiac developmental and functional abnormalities in pulmonary atresia with intact ventricular septum (PAIVS) free from effects secondary to anatomic defects, we performed and compared single‐cell transcriptomic and phenotypic analyses of patient‐ and healthy...

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Detalles Bibliográficos
Autores principales: Lam, Yin‐Yu, Keung, Wendy, Chan, Chun‐Ho, Geng, Lin, Wong, Nicodemus, Brenière‐Letuffe, David, Li, Ronald A., Cheung, Yiu‐Fai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763394/
https://www.ncbi.nlm.nih.gov/pubmed/33059525
http://dx.doi.org/10.1161/JAHA.120.016528

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