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Natural-Based Hydrogels for Tissue Engineering Applications

In the field of tissue engineering and regenerative medicine, hydrogels are used as biomaterials to support cell attachment and promote tissue regeneration due to their unique biomimetic characteristics. The use of natural-origin materials significantly influenced the origin and progress of the fiel...

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Autores principales: Gomez-Florit, Manuel, Pardo, Alberto, Domingues, Rui M. A., Graça, Ana L., Babo, Pedro S., Reis, Rui L., Gomes, Manuela E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763437/
https://www.ncbi.nlm.nih.gov/pubmed/33322369
http://dx.doi.org/10.3390/molecules25245858
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author Gomez-Florit, Manuel
Pardo, Alberto
Domingues, Rui M. A.
Graça, Ana L.
Babo, Pedro S.
Reis, Rui L.
Gomes, Manuela E.
author_facet Gomez-Florit, Manuel
Pardo, Alberto
Domingues, Rui M. A.
Graça, Ana L.
Babo, Pedro S.
Reis, Rui L.
Gomes, Manuela E.
author_sort Gomez-Florit, Manuel
collection PubMed
description In the field of tissue engineering and regenerative medicine, hydrogels are used as biomaterials to support cell attachment and promote tissue regeneration due to their unique biomimetic characteristics. The use of natural-origin materials significantly influenced the origin and progress of the field due to their ability to mimic the native tissues’ extracellular matrix and biocompatibility. However, the majority of these natural materials failed to provide satisfactory cues to guide cell differentiation toward the formation of new tissues. In addition, the integration of technological advances, such as 3D printing, microfluidics and nanotechnology, in tissue engineering has obsoleted the first generation of natural-origin hydrogels. During the last decade, a new generation of hydrogels has emerged to meet the specific tissue necessities, to be used with state-of-the-art techniques and to capitalize the intrinsic characteristics of natural-based materials. In this review, we briefly examine important hydrogel crosslinking mechanisms. Then, the latest developments in engineering natural-based hydrogels are investigated and major applications in the field of tissue engineering and regenerative medicine are highlighted. Finally, the current limitations, future challenges and opportunities in this field are discussed to encourage realistic developments for the clinical translation of tissue engineering strategies.
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spelling pubmed-77634372020-12-27 Natural-Based Hydrogels for Tissue Engineering Applications Gomez-Florit, Manuel Pardo, Alberto Domingues, Rui M. A. Graça, Ana L. Babo, Pedro S. Reis, Rui L. Gomes, Manuela E. Molecules Review In the field of tissue engineering and regenerative medicine, hydrogels are used as biomaterials to support cell attachment and promote tissue regeneration due to their unique biomimetic characteristics. The use of natural-origin materials significantly influenced the origin and progress of the field due to their ability to mimic the native tissues’ extracellular matrix and biocompatibility. However, the majority of these natural materials failed to provide satisfactory cues to guide cell differentiation toward the formation of new tissues. In addition, the integration of technological advances, such as 3D printing, microfluidics and nanotechnology, in tissue engineering has obsoleted the first generation of natural-origin hydrogels. During the last decade, a new generation of hydrogels has emerged to meet the specific tissue necessities, to be used with state-of-the-art techniques and to capitalize the intrinsic characteristics of natural-based materials. In this review, we briefly examine important hydrogel crosslinking mechanisms. Then, the latest developments in engineering natural-based hydrogels are investigated and major applications in the field of tissue engineering and regenerative medicine are highlighted. Finally, the current limitations, future challenges and opportunities in this field are discussed to encourage realistic developments for the clinical translation of tissue engineering strategies. MDPI 2020-12-11 /pmc/articles/PMC7763437/ /pubmed/33322369 http://dx.doi.org/10.3390/molecules25245858 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gomez-Florit, Manuel
Pardo, Alberto
Domingues, Rui M. A.
Graça, Ana L.
Babo, Pedro S.
Reis, Rui L.
Gomes, Manuela E.
Natural-Based Hydrogels for Tissue Engineering Applications
title Natural-Based Hydrogels for Tissue Engineering Applications
title_full Natural-Based Hydrogels for Tissue Engineering Applications
title_fullStr Natural-Based Hydrogels for Tissue Engineering Applications
title_full_unstemmed Natural-Based Hydrogels for Tissue Engineering Applications
title_short Natural-Based Hydrogels for Tissue Engineering Applications
title_sort natural-based hydrogels for tissue engineering applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763437/
https://www.ncbi.nlm.nih.gov/pubmed/33322369
http://dx.doi.org/10.3390/molecules25245858
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