Cargando…
Natural-Based Hydrogels for Tissue Engineering Applications
In the field of tissue engineering and regenerative medicine, hydrogels are used as biomaterials to support cell attachment and promote tissue regeneration due to their unique biomimetic characteristics. The use of natural-origin materials significantly influenced the origin and progress of the fiel...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763437/ https://www.ncbi.nlm.nih.gov/pubmed/33322369 http://dx.doi.org/10.3390/molecules25245858 |
_version_ | 1783628018343739392 |
---|---|
author | Gomez-Florit, Manuel Pardo, Alberto Domingues, Rui M. A. Graça, Ana L. Babo, Pedro S. Reis, Rui L. Gomes, Manuela E. |
author_facet | Gomez-Florit, Manuel Pardo, Alberto Domingues, Rui M. A. Graça, Ana L. Babo, Pedro S. Reis, Rui L. Gomes, Manuela E. |
author_sort | Gomez-Florit, Manuel |
collection | PubMed |
description | In the field of tissue engineering and regenerative medicine, hydrogels are used as biomaterials to support cell attachment and promote tissue regeneration due to their unique biomimetic characteristics. The use of natural-origin materials significantly influenced the origin and progress of the field due to their ability to mimic the native tissues’ extracellular matrix and biocompatibility. However, the majority of these natural materials failed to provide satisfactory cues to guide cell differentiation toward the formation of new tissues. In addition, the integration of technological advances, such as 3D printing, microfluidics and nanotechnology, in tissue engineering has obsoleted the first generation of natural-origin hydrogels. During the last decade, a new generation of hydrogels has emerged to meet the specific tissue necessities, to be used with state-of-the-art techniques and to capitalize the intrinsic characteristics of natural-based materials. In this review, we briefly examine important hydrogel crosslinking mechanisms. Then, the latest developments in engineering natural-based hydrogels are investigated and major applications in the field of tissue engineering and regenerative medicine are highlighted. Finally, the current limitations, future challenges and opportunities in this field are discussed to encourage realistic developments for the clinical translation of tissue engineering strategies. |
format | Online Article Text |
id | pubmed-7763437 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77634372020-12-27 Natural-Based Hydrogels for Tissue Engineering Applications Gomez-Florit, Manuel Pardo, Alberto Domingues, Rui M. A. Graça, Ana L. Babo, Pedro S. Reis, Rui L. Gomes, Manuela E. Molecules Review In the field of tissue engineering and regenerative medicine, hydrogels are used as biomaterials to support cell attachment and promote tissue regeneration due to their unique biomimetic characteristics. The use of natural-origin materials significantly influenced the origin and progress of the field due to their ability to mimic the native tissues’ extracellular matrix and biocompatibility. However, the majority of these natural materials failed to provide satisfactory cues to guide cell differentiation toward the formation of new tissues. In addition, the integration of technological advances, such as 3D printing, microfluidics and nanotechnology, in tissue engineering has obsoleted the first generation of natural-origin hydrogels. During the last decade, a new generation of hydrogels has emerged to meet the specific tissue necessities, to be used with state-of-the-art techniques and to capitalize the intrinsic characteristics of natural-based materials. In this review, we briefly examine important hydrogel crosslinking mechanisms. Then, the latest developments in engineering natural-based hydrogels are investigated and major applications in the field of tissue engineering and regenerative medicine are highlighted. Finally, the current limitations, future challenges and opportunities in this field are discussed to encourage realistic developments for the clinical translation of tissue engineering strategies. MDPI 2020-12-11 /pmc/articles/PMC7763437/ /pubmed/33322369 http://dx.doi.org/10.3390/molecules25245858 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gomez-Florit, Manuel Pardo, Alberto Domingues, Rui M. A. Graça, Ana L. Babo, Pedro S. Reis, Rui L. Gomes, Manuela E. Natural-Based Hydrogels for Tissue Engineering Applications |
title | Natural-Based Hydrogels for Tissue Engineering Applications |
title_full | Natural-Based Hydrogels for Tissue Engineering Applications |
title_fullStr | Natural-Based Hydrogels for Tissue Engineering Applications |
title_full_unstemmed | Natural-Based Hydrogels for Tissue Engineering Applications |
title_short | Natural-Based Hydrogels for Tissue Engineering Applications |
title_sort | natural-based hydrogels for tissue engineering applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763437/ https://www.ncbi.nlm.nih.gov/pubmed/33322369 http://dx.doi.org/10.3390/molecules25245858 |
work_keys_str_mv | AT gomezfloritmanuel naturalbasedhydrogelsfortissueengineeringapplications AT pardoalberto naturalbasedhydrogelsfortissueengineeringapplications AT dominguesruima naturalbasedhydrogelsfortissueengineeringapplications AT gracaanal naturalbasedhydrogelsfortissueengineeringapplications AT babopedros naturalbasedhydrogelsfortissueengineeringapplications AT reisruil naturalbasedhydrogelsfortissueengineeringapplications AT gomesmanuelae naturalbasedhydrogelsfortissueengineeringapplications |