TRPML1—Emerging Roles in Cancer

The mucolipin-1 (TRPML1) channel maintains lysosomal ionic homeostasis and regulates autophagic flux. Defects of TRPML1 lead to lysosomal storage diseases and neurodegeneration. In this report, we discuss emerging evidence pertaining to differential regulation of TRPML1 signaling pathways in cancer...

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Detalles Bibliográficos
Autores principales: Yang, Yiming, Zhai, Xingjian, El Hiani, Yassine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763474/
https://www.ncbi.nlm.nih.gov/pubmed/33322223
http://dx.doi.org/10.3390/cells9122682
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author Yang, Yiming
Zhai, Xingjian
El Hiani, Yassine
author_facet Yang, Yiming
Zhai, Xingjian
El Hiani, Yassine
author_sort Yang, Yiming
collection PubMed
description The mucolipin-1 (TRPML1) channel maintains lysosomal ionic homeostasis and regulates autophagic flux. Defects of TRPML1 lead to lysosomal storage diseases and neurodegeneration. In this report, we discuss emerging evidence pertaining to differential regulation of TRPML1 signaling pathways in cancer progression with the goal of leveraging the oncogenic potential of TRPML1 to inspire therapeutic interventions.
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spelling pubmed-77634742020-12-27 TRPML1—Emerging Roles in Cancer Yang, Yiming Zhai, Xingjian El Hiani, Yassine Cells Brief Report The mucolipin-1 (TRPML1) channel maintains lysosomal ionic homeostasis and regulates autophagic flux. Defects of TRPML1 lead to lysosomal storage diseases and neurodegeneration. In this report, we discuss emerging evidence pertaining to differential regulation of TRPML1 signaling pathways in cancer progression with the goal of leveraging the oncogenic potential of TRPML1 to inspire therapeutic interventions. MDPI 2020-12-13 /pmc/articles/PMC7763474/ /pubmed/33322223 http://dx.doi.org/10.3390/cells9122682 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Yang, Yiming
Zhai, Xingjian
El Hiani, Yassine
TRPML1—Emerging Roles in Cancer
title TRPML1—Emerging Roles in Cancer
title_full TRPML1—Emerging Roles in Cancer
title_fullStr TRPML1—Emerging Roles in Cancer
title_full_unstemmed TRPML1—Emerging Roles in Cancer
title_short TRPML1—Emerging Roles in Cancer
title_sort trpml1—emerging roles in cancer
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763474/
https://www.ncbi.nlm.nih.gov/pubmed/33322223
http://dx.doi.org/10.3390/cells9122682
work_keys_str_mv AT yangyiming trpml1emergingrolesincancer
AT zhaixingjian trpml1emergingrolesincancer
AT elhianiyassine trpml1emergingrolesincancer

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