PDI Family Members as Guides for Client Folding and Assembly

Complicated and sophisticated protein homeostasis (proteostasis) networks in the endoplasmic reticulum (ER), comprising disulfide catalysts, molecular chaperones, and their regulators, help to maintain cell viability. Newly synthesized proteins inserted into the ER need to fold and assemble into uni...

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Detalles Bibliográficos
Autores principales: Kanemura, Shingo, Matsusaki, Motonori, Inaba, Kenji, Okumura, Masaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763558/
https://www.ncbi.nlm.nih.gov/pubmed/33302492
http://dx.doi.org/10.3390/ijms21249351
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author Kanemura, Shingo
Matsusaki, Motonori
Inaba, Kenji
Okumura, Masaki
author_facet Kanemura, Shingo
Matsusaki, Motonori
Inaba, Kenji
Okumura, Masaki
author_sort Kanemura, Shingo
collection PubMed
description Complicated and sophisticated protein homeostasis (proteostasis) networks in the endoplasmic reticulum (ER), comprising disulfide catalysts, molecular chaperones, and their regulators, help to maintain cell viability. Newly synthesized proteins inserted into the ER need to fold and assemble into unique native structures to fulfill their physiological functions, and this is assisted by protein disulfide isomerase (PDI) family. Herein, we focus on recent advances in understanding the detailed mechanisms of PDI family members as guides for client folding and assembly to ensure the efficient production of secretory proteins.
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spelling pubmed-77635582020-12-27 PDI Family Members as Guides for Client Folding and Assembly Kanemura, Shingo Matsusaki, Motonori Inaba, Kenji Okumura, Masaki Int J Mol Sci Review Complicated and sophisticated protein homeostasis (proteostasis) networks in the endoplasmic reticulum (ER), comprising disulfide catalysts, molecular chaperones, and their regulators, help to maintain cell viability. Newly synthesized proteins inserted into the ER need to fold and assemble into unique native structures to fulfill their physiological functions, and this is assisted by protein disulfide isomerase (PDI) family. Herein, we focus on recent advances in understanding the detailed mechanisms of PDI family members as guides for client folding and assembly to ensure the efficient production of secretory proteins. MDPI 2020-12-08 /pmc/articles/PMC7763558/ /pubmed/33302492 http://dx.doi.org/10.3390/ijms21249351 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kanemura, Shingo
Matsusaki, Motonori
Inaba, Kenji
Okumura, Masaki
PDI Family Members as Guides for Client Folding and Assembly
title PDI Family Members as Guides for Client Folding and Assembly
title_full PDI Family Members as Guides for Client Folding and Assembly
title_fullStr PDI Family Members as Guides for Client Folding and Assembly
title_full_unstemmed PDI Family Members as Guides for Client Folding and Assembly
title_short PDI Family Members as Guides for Client Folding and Assembly
title_sort pdi family members as guides for client folding and assembly
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763558/
https://www.ncbi.nlm.nih.gov/pubmed/33302492
http://dx.doi.org/10.3390/ijms21249351
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AT okumuramasaki pdifamilymembersasguidesforclientfoldingandassembly

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