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The Microbiota/Host Immune System Interaction in the Nose to Protect from COVID-19
Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is characterized by variable clinical presentation that ranges from asymptomatic to fatal multi-organ damage. The site of entry and the response of the host to the infection affect t...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763594/ https://www.ncbi.nlm.nih.gov/pubmed/33322584 http://dx.doi.org/10.3390/life10120345 |
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author | Di Stadio, Arianna Costantini, Claudio Renga, Giorgia Pariano, Marilena Ricci, Giampietro Romani, Luigina |
author_facet | Di Stadio, Arianna Costantini, Claudio Renga, Giorgia Pariano, Marilena Ricci, Giampietro Romani, Luigina |
author_sort | Di Stadio, Arianna |
collection | PubMed |
description | Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is characterized by variable clinical presentation that ranges from asymptomatic to fatal multi-organ damage. The site of entry and the response of the host to the infection affect the outcomes. The role of the upper airways and the nasal barrier in the prevention of infection is increasingly being recognized. Besides the epithelial lining and the local immune system, the upper airways harbor a community of microorganisms, or microbiota, that takes an active part in mucosal homeostasis and in resistance to infection. However, the role of the upper airway microbiota in COVID-19 is not yet completely understood and likely goes beyond protection from viral entry to include the regulation of the immune response to the infection. Herein, we discuss the hypothesis that restoring endogenous barriers and anti-inflammatory pathways that are defective in COVID-19 patients might represent a valid strategy to reduce infectivity and ameliorate clinical symptomatology. |
format | Online Article Text |
id | pubmed-7763594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77635942020-12-27 The Microbiota/Host Immune System Interaction in the Nose to Protect from COVID-19 Di Stadio, Arianna Costantini, Claudio Renga, Giorgia Pariano, Marilena Ricci, Giampietro Romani, Luigina Life (Basel) Review Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is characterized by variable clinical presentation that ranges from asymptomatic to fatal multi-organ damage. The site of entry and the response of the host to the infection affect the outcomes. The role of the upper airways and the nasal barrier in the prevention of infection is increasingly being recognized. Besides the epithelial lining and the local immune system, the upper airways harbor a community of microorganisms, or microbiota, that takes an active part in mucosal homeostasis and in resistance to infection. However, the role of the upper airway microbiota in COVID-19 is not yet completely understood and likely goes beyond protection from viral entry to include the regulation of the immune response to the infection. Herein, we discuss the hypothesis that restoring endogenous barriers and anti-inflammatory pathways that are defective in COVID-19 patients might represent a valid strategy to reduce infectivity and ameliorate clinical symptomatology. MDPI 2020-12-11 /pmc/articles/PMC7763594/ /pubmed/33322584 http://dx.doi.org/10.3390/life10120345 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Di Stadio, Arianna Costantini, Claudio Renga, Giorgia Pariano, Marilena Ricci, Giampietro Romani, Luigina The Microbiota/Host Immune System Interaction in the Nose to Protect from COVID-19 |
title | The Microbiota/Host Immune System Interaction in the Nose to Protect from COVID-19 |
title_full | The Microbiota/Host Immune System Interaction in the Nose to Protect from COVID-19 |
title_fullStr | The Microbiota/Host Immune System Interaction in the Nose to Protect from COVID-19 |
title_full_unstemmed | The Microbiota/Host Immune System Interaction in the Nose to Protect from COVID-19 |
title_short | The Microbiota/Host Immune System Interaction in the Nose to Protect from COVID-19 |
title_sort | microbiota/host immune system interaction in the nose to protect from covid-19 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763594/ https://www.ncbi.nlm.nih.gov/pubmed/33322584 http://dx.doi.org/10.3390/life10120345 |
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