Structural Basis for Design of New Purine-Based Inhibitors Targeting the Hydrophobic Binding Pocket of Hsp90

Inhibition of the molecular chaperone heat shock protein 90 (Hsp90) represents a promising approach for cancer treatment. BIIB021 is a highly potent Hsp90 inhibitor with remarkable anticancer activity; however, its clinical application is limited by lack of potency and response. In this study, we ai...

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Detalles Bibliográficos
Autores principales: Shin, Sang Chul, El-Damasy, Ashraf K., Lee, Ju Hyeon, Seo, Seon Hee, Kim, Ji Hyun, Seo, Young Ho, Lee, Yuri, Yu, Ji Hoon, Bang, Eun Kyoung, Kim, Eunice EunKyeong, Keum, Gyochang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763603/
https://www.ncbi.nlm.nih.gov/pubmed/33317068
http://dx.doi.org/10.3390/ijms21249377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763603/
https://www.ncbi.nlm.nih.gov/pubmed/33317068
http://dx.doi.org/10.3390/ijms21249377

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