Cargando…

Sex Differences in Longitudinal Determinants of Carotid Intima Medial Thickening With Aging in a Community‐Dwelling Population: The Baltimore Longitudinal Study on Aging

BACKGROUND: Common carotid intima medial thickness (IMT) increases with aging. However, the longitudinal association between IMT and other age‐associated hemodynamic alterations in men and in women are not fully explored. METHODS AND RESULTS: We analyzed repeated measures of IMT, blood pressure, and...

Descripción completa

Detalles Bibliográficos
Autores principales: Karikkineth, Ajoy C., AlGhatrif, Majd, Oberdier, Matt T., Morrell, Chris, Palchamy, Elango, Strait, James B., Ferrucci, Luigi, Lakatta, Edward G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763739/
https://www.ncbi.nlm.nih.gov/pubmed/33164652
http://dx.doi.org/10.1161/JAHA.119.015396
_version_ 1783628089830408192
author Karikkineth, Ajoy C.
AlGhatrif, Majd
Oberdier, Matt T.
Morrell, Chris
Palchamy, Elango
Strait, James B.
Ferrucci, Luigi
Lakatta, Edward G.
author_facet Karikkineth, Ajoy C.
AlGhatrif, Majd
Oberdier, Matt T.
Morrell, Chris
Palchamy, Elango
Strait, James B.
Ferrucci, Luigi
Lakatta, Edward G.
author_sort Karikkineth, Ajoy C.
collection PubMed
description BACKGROUND: Common carotid intima medial thickness (IMT) increases with aging. However, the longitudinal association between IMT and other age‐associated hemodynamic alterations in men and in women are not fully explored. METHODS AND RESULTS: We analyzed repeated measures of IMT, blood pressure, and carotid‐femoral pulse wave velocity over a 20‐year period in 1067 men and women of the Baltimore Longitudinal Study on Aging; participants were ages 20 to 92 years at entry and free of overt cardiovascular disease. Linear mixed‐effects models were used to calculate the individual rates of change ((Change)) of IMT, pulse pressure, mean arterial pressure, and pulse wave velocity, among other covariates. Multivariate regression analysis was used to examine the association of IMT(Change) with baseline and rates of change of hemodynamic parameters and cardiovascular risk factors. IMT increased at accelerating rates from 0.02 mm/decade at age 50 years to 0.05 mm/decade at age 80 years greater rates in men than in women. IMT(Change) was positively associated with baseline low‐density lipoprotein, low‐density lipoprotein(Change), and baseline systolic blood pressure and systolic blood pressure(Change), but inversely with baseline diastolic blood pressure and diastolic blood pressure(Change). When blood pressure was expressed as pulse pressure and MAP, IMT(Change) was positively associated with baseline pulse pressure and pulse pressure(Change) and inversely with baseline mean arterial pressure and mean arterial pressure(Change). In sex‐specific analysis, these associations were observed in women, but not in men. CONCLUSIONS: In summary, our analyses showed that IMT increases at accelerating rates with aging. Age‐associated changes in IMT were modulated by concurrent changes of low‐density lipoprotein in both sexes, and of pulsatile and mean blood pressure in women but not men.
format Online
Article
Text
id pubmed-7763739
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-77637392020-12-28 Sex Differences in Longitudinal Determinants of Carotid Intima Medial Thickening With Aging in a Community‐Dwelling Population: The Baltimore Longitudinal Study on Aging Karikkineth, Ajoy C. AlGhatrif, Majd Oberdier, Matt T. Morrell, Chris Palchamy, Elango Strait, James B. Ferrucci, Luigi Lakatta, Edward G. J Am Heart Assoc Original Research BACKGROUND: Common carotid intima medial thickness (IMT) increases with aging. However, the longitudinal association between IMT and other age‐associated hemodynamic alterations in men and in women are not fully explored. METHODS AND RESULTS: We analyzed repeated measures of IMT, blood pressure, and carotid‐femoral pulse wave velocity over a 20‐year period in 1067 men and women of the Baltimore Longitudinal Study on Aging; participants were ages 20 to 92 years at entry and free of overt cardiovascular disease. Linear mixed‐effects models were used to calculate the individual rates of change ((Change)) of IMT, pulse pressure, mean arterial pressure, and pulse wave velocity, among other covariates. Multivariate regression analysis was used to examine the association of IMT(Change) with baseline and rates of change of hemodynamic parameters and cardiovascular risk factors. IMT increased at accelerating rates from 0.02 mm/decade at age 50 years to 0.05 mm/decade at age 80 years greater rates in men than in women. IMT(Change) was positively associated with baseline low‐density lipoprotein, low‐density lipoprotein(Change), and baseline systolic blood pressure and systolic blood pressure(Change), but inversely with baseline diastolic blood pressure and diastolic blood pressure(Change). When blood pressure was expressed as pulse pressure and MAP, IMT(Change) was positively associated with baseline pulse pressure and pulse pressure(Change) and inversely with baseline mean arterial pressure and mean arterial pressure(Change). In sex‐specific analysis, these associations were observed in women, but not in men. CONCLUSIONS: In summary, our analyses showed that IMT increases at accelerating rates with aging. Age‐associated changes in IMT were modulated by concurrent changes of low‐density lipoprotein in both sexes, and of pulsatile and mean blood pressure in women but not men. John Wiley and Sons Inc. 2020-11-07 /pmc/articles/PMC7763739/ /pubmed/33164652 http://dx.doi.org/10.1161/JAHA.119.015396 Text en © 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Karikkineth, Ajoy C.
AlGhatrif, Majd
Oberdier, Matt T.
Morrell, Chris
Palchamy, Elango
Strait, James B.
Ferrucci, Luigi
Lakatta, Edward G.
Sex Differences in Longitudinal Determinants of Carotid Intima Medial Thickening With Aging in a Community‐Dwelling Population: The Baltimore Longitudinal Study on Aging
title Sex Differences in Longitudinal Determinants of Carotid Intima Medial Thickening With Aging in a Community‐Dwelling Population: The Baltimore Longitudinal Study on Aging
title_full Sex Differences in Longitudinal Determinants of Carotid Intima Medial Thickening With Aging in a Community‐Dwelling Population: The Baltimore Longitudinal Study on Aging
title_fullStr Sex Differences in Longitudinal Determinants of Carotid Intima Medial Thickening With Aging in a Community‐Dwelling Population: The Baltimore Longitudinal Study on Aging
title_full_unstemmed Sex Differences in Longitudinal Determinants of Carotid Intima Medial Thickening With Aging in a Community‐Dwelling Population: The Baltimore Longitudinal Study on Aging
title_short Sex Differences in Longitudinal Determinants of Carotid Intima Medial Thickening With Aging in a Community‐Dwelling Population: The Baltimore Longitudinal Study on Aging
title_sort sex differences in longitudinal determinants of carotid intima medial thickening with aging in a community‐dwelling population: the baltimore longitudinal study on aging
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763739/
https://www.ncbi.nlm.nih.gov/pubmed/33164652
http://dx.doi.org/10.1161/JAHA.119.015396
work_keys_str_mv AT karikkinethajoyc sexdifferencesinlongitudinaldeterminantsofcarotidintimamedialthickeningwithaginginacommunitydwellingpopulationthebaltimorelongitudinalstudyonaging
AT alghatrifmajd sexdifferencesinlongitudinaldeterminantsofcarotidintimamedialthickeningwithaginginacommunitydwellingpopulationthebaltimorelongitudinalstudyonaging
AT oberdiermattt sexdifferencesinlongitudinaldeterminantsofcarotidintimamedialthickeningwithaginginacommunitydwellingpopulationthebaltimorelongitudinalstudyonaging
AT morrellchris sexdifferencesinlongitudinaldeterminantsofcarotidintimamedialthickeningwithaginginacommunitydwellingpopulationthebaltimorelongitudinalstudyonaging
AT palchamyelango sexdifferencesinlongitudinaldeterminantsofcarotidintimamedialthickeningwithaginginacommunitydwellingpopulationthebaltimorelongitudinalstudyonaging
AT straitjamesb sexdifferencesinlongitudinaldeterminantsofcarotidintimamedialthickeningwithaginginacommunitydwellingpopulationthebaltimorelongitudinalstudyonaging
AT ferrucciluigi sexdifferencesinlongitudinaldeterminantsofcarotidintimamedialthickeningwithaginginacommunitydwellingpopulationthebaltimorelongitudinalstudyonaging
AT lakattaedwardg sexdifferencesinlongitudinaldeterminantsofcarotidintimamedialthickeningwithaginginacommunitydwellingpopulationthebaltimorelongitudinalstudyonaging