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Sex Differences in Longitudinal Determinants of Carotid Intima Medial Thickening With Aging in a Community‐Dwelling Population: The Baltimore Longitudinal Study on Aging
BACKGROUND: Common carotid intima medial thickness (IMT) increases with aging. However, the longitudinal association between IMT and other age‐associated hemodynamic alterations in men and in women are not fully explored. METHODS AND RESULTS: We analyzed repeated measures of IMT, blood pressure, and...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763739/ https://www.ncbi.nlm.nih.gov/pubmed/33164652 http://dx.doi.org/10.1161/JAHA.119.015396 |
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author | Karikkineth, Ajoy C. AlGhatrif, Majd Oberdier, Matt T. Morrell, Chris Palchamy, Elango Strait, James B. Ferrucci, Luigi Lakatta, Edward G. |
author_facet | Karikkineth, Ajoy C. AlGhatrif, Majd Oberdier, Matt T. Morrell, Chris Palchamy, Elango Strait, James B. Ferrucci, Luigi Lakatta, Edward G. |
author_sort | Karikkineth, Ajoy C. |
collection | PubMed |
description | BACKGROUND: Common carotid intima medial thickness (IMT) increases with aging. However, the longitudinal association between IMT and other age‐associated hemodynamic alterations in men and in women are not fully explored. METHODS AND RESULTS: We analyzed repeated measures of IMT, blood pressure, and carotid‐femoral pulse wave velocity over a 20‐year period in 1067 men and women of the Baltimore Longitudinal Study on Aging; participants were ages 20 to 92 years at entry and free of overt cardiovascular disease. Linear mixed‐effects models were used to calculate the individual rates of change ((Change)) of IMT, pulse pressure, mean arterial pressure, and pulse wave velocity, among other covariates. Multivariate regression analysis was used to examine the association of IMT(Change) with baseline and rates of change of hemodynamic parameters and cardiovascular risk factors. IMT increased at accelerating rates from 0.02 mm/decade at age 50 years to 0.05 mm/decade at age 80 years greater rates in men than in women. IMT(Change) was positively associated with baseline low‐density lipoprotein, low‐density lipoprotein(Change), and baseline systolic blood pressure and systolic blood pressure(Change), but inversely with baseline diastolic blood pressure and diastolic blood pressure(Change). When blood pressure was expressed as pulse pressure and MAP, IMT(Change) was positively associated with baseline pulse pressure and pulse pressure(Change) and inversely with baseline mean arterial pressure and mean arterial pressure(Change). In sex‐specific analysis, these associations were observed in women, but not in men. CONCLUSIONS: In summary, our analyses showed that IMT increases at accelerating rates with aging. Age‐associated changes in IMT were modulated by concurrent changes of low‐density lipoprotein in both sexes, and of pulsatile and mean blood pressure in women but not men. |
format | Online Article Text |
id | pubmed-7763739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77637392020-12-28 Sex Differences in Longitudinal Determinants of Carotid Intima Medial Thickening With Aging in a Community‐Dwelling Population: The Baltimore Longitudinal Study on Aging Karikkineth, Ajoy C. AlGhatrif, Majd Oberdier, Matt T. Morrell, Chris Palchamy, Elango Strait, James B. Ferrucci, Luigi Lakatta, Edward G. J Am Heart Assoc Original Research BACKGROUND: Common carotid intima medial thickness (IMT) increases with aging. However, the longitudinal association between IMT and other age‐associated hemodynamic alterations in men and in women are not fully explored. METHODS AND RESULTS: We analyzed repeated measures of IMT, blood pressure, and carotid‐femoral pulse wave velocity over a 20‐year period in 1067 men and women of the Baltimore Longitudinal Study on Aging; participants were ages 20 to 92 years at entry and free of overt cardiovascular disease. Linear mixed‐effects models were used to calculate the individual rates of change ((Change)) of IMT, pulse pressure, mean arterial pressure, and pulse wave velocity, among other covariates. Multivariate regression analysis was used to examine the association of IMT(Change) with baseline and rates of change of hemodynamic parameters and cardiovascular risk factors. IMT increased at accelerating rates from 0.02 mm/decade at age 50 years to 0.05 mm/decade at age 80 years greater rates in men than in women. IMT(Change) was positively associated with baseline low‐density lipoprotein, low‐density lipoprotein(Change), and baseline systolic blood pressure and systolic blood pressure(Change), but inversely with baseline diastolic blood pressure and diastolic blood pressure(Change). When blood pressure was expressed as pulse pressure and MAP, IMT(Change) was positively associated with baseline pulse pressure and pulse pressure(Change) and inversely with baseline mean arterial pressure and mean arterial pressure(Change). In sex‐specific analysis, these associations were observed in women, but not in men. CONCLUSIONS: In summary, our analyses showed that IMT increases at accelerating rates with aging. Age‐associated changes in IMT were modulated by concurrent changes of low‐density lipoprotein in both sexes, and of pulsatile and mean blood pressure in women but not men. John Wiley and Sons Inc. 2020-11-07 /pmc/articles/PMC7763739/ /pubmed/33164652 http://dx.doi.org/10.1161/JAHA.119.015396 Text en © 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Research Karikkineth, Ajoy C. AlGhatrif, Majd Oberdier, Matt T. Morrell, Chris Palchamy, Elango Strait, James B. Ferrucci, Luigi Lakatta, Edward G. Sex Differences in Longitudinal Determinants of Carotid Intima Medial Thickening With Aging in a Community‐Dwelling Population: The Baltimore Longitudinal Study on Aging |
title | Sex Differences in Longitudinal Determinants of Carotid Intima Medial Thickening With Aging in a Community‐Dwelling Population: The Baltimore Longitudinal Study on Aging |
title_full | Sex Differences in Longitudinal Determinants of Carotid Intima Medial Thickening With Aging in a Community‐Dwelling Population: The Baltimore Longitudinal Study on Aging |
title_fullStr | Sex Differences in Longitudinal Determinants of Carotid Intima Medial Thickening With Aging in a Community‐Dwelling Population: The Baltimore Longitudinal Study on Aging |
title_full_unstemmed | Sex Differences in Longitudinal Determinants of Carotid Intima Medial Thickening With Aging in a Community‐Dwelling Population: The Baltimore Longitudinal Study on Aging |
title_short | Sex Differences in Longitudinal Determinants of Carotid Intima Medial Thickening With Aging in a Community‐Dwelling Population: The Baltimore Longitudinal Study on Aging |
title_sort | sex differences in longitudinal determinants of carotid intima medial thickening with aging in a community‐dwelling population: the baltimore longitudinal study on aging |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763739/ https://www.ncbi.nlm.nih.gov/pubmed/33164652 http://dx.doi.org/10.1161/JAHA.119.015396 |
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