Cargando…

Aging Impairs Mitochondrial Function and Mitophagy and Elevates Interleukin 6 Within the Cerebral Vasculature

BACKGROUND: The blood‐brain barrier (BBB) is critical for cerebrovascular health. Although aging impairs the integrity of the BBB, the mechanisms behind this phenomenon are not clear. As mitochondrial components activate inflammation as mitochondria become dysfunctional, we examined how aging impact...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tyrrell, Daniel J., Blin, Muriel G., Song, Jianrui, Wood, Sherri C., Goldstein, Daniel R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763766/ https://www.ncbi.nlm.nih.gov/pubmed/33225820 http://dx.doi.org/10.1161/JAHA.120.017820

Ejemplares similares

Age‐associated adipose tissue inflammation promotes monocyte chemotaxis and enhances atherosclerosis
por: Song, Jianrui, et al.
Publicado: (2023)

Pathological changes within the cerebral vasculature in Alzheimer’s disease: New perspectives
por: Fisher, Robert A., et al.
Publicado: (2022)

Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission
por: Shyamsunder, Pavithra, et al.
Publicado: (2016)

Intracardiac Myxoma, Cerebral Aneurysms and Elevated Interleukin-6
por: Ezerioha, Nnadozie, et al.
Publicado: (2015)

Participation of mitochondrial fission during mitophagy
por: Mao, Kai, et al.
Publicado: (2013)

Cellular and Oxidative Mechanisms Associated with Interleukin-6 Signaling in the Vasculature
por: Didion, Sean P.
Publicado: (2017)

The Cerefy(®) Atlas of Cerebral Vasculature
por: Dye, Justin
Publicado: (2010)

The cerefy® Atlas of Cerebral Vasculature
por: Kubben, Pieter L.
Publicado: (2010)

SARS-CoV-2 Causes Mitochondrial Dysfunction and Mitophagy Impairment
por: Shang, Chao, et al.
Publicado: (2022)

Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy
por: Lee, Joo-Yong, et al.
Publicado: (2010)

Prototyping of cerebral vasculature physical models
por: Khan, Imad S., et al.
Publicado: (2014)

PINK1-Dependent Mitophagy Inhibits Elevated Ubiquitin Phosphorylation Caused by Mitochondrial Damage
por: Lambourne, Olivia A., et al.
Publicado: (2023)

Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin
por: Hu, Yu, et al.
Publicado: (2016)

Parkinson’s disease–associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagy
por: Ma, Kai Yu, et al.
Publicado: (2021)

Simultaneous impairment of mitochondrial fission and fusion reduces mitophagy and shortens replicative lifespan
por: Bernhardt, Dominik, et al.
Publicado: (2015)

Mitochondrial Oxidative Stress and Mitophagy Activation Contribute to TNF-Dependent Impairment of Myogenesis
por: Chernyavskij, Daniil A., et al.
Publicado: (2023)

Epigenetic Control of Mitochondrial Function in the Vasculature
por: Mohammed, Shafeeq A., et al.
Publicado: (2020)

The critical roles of mitophagy in cerebral ischemia
por: Tang, Yan-Cheng, et al.
Publicado: (2016)

Pancreatic β cells overexpressing hIAPP impaired mitophagy and unbalanced mitochondrial dynamics
por: Hernández, Miriam García, et al.
Publicado: (2018)

Drosophila MICOS knockdown impairs mitochondrial structure and function and promotes mitophagy in muscle tissue
por: Wang, Li-jie, et al.
Publicado: (2020)

Bioenergetic failure, mitochondrial dysfunction and mitophagy
por: Beart, Philip
Publicado: (2015)

Mitophagy, Mitochondrial Homeostasis, and Cell Fate
por: Ma, Kaili, et al.
Publicado: (2020)

Mitochondrial Dynamics and Mitophagy in Cardiometabolic Disease
por: Lin, Jianguo, et al.
Publicado: (2022)

Mitochondrial Biogenesis, Mitochondrial Dynamics, and Mitophagy in the Maturation of Cardiomyocytes
por: Ding, Qianqian, et al.
Publicado: (2021)

Vascular Reactivity to Hypercapnia Is Impaired in the Cerebral and Retinal Vasculature in the Acute Phase After Experimental Subarachnoid Hemorrhage
por: Warner, Laura, et al.
Publicado: (2022)

Elevated interleukin-6 levels are associated with impaired outcome in cardiac transthyretin amyloidosis
por: Hein, Selina J, et al.
Publicado: (2021)

Mitophagy in Cerebral Ischemia and Ischemia/Reperfusion Injury
por: Shen, Luoan, et al.
Publicado: (2021)

Research progress of mitophagy in chronic cerebral ischemia
por: Yu, Mayue, et al.
Publicado: (2023)

Elevated PDGF‐BB from Bone Impairs Hippocampal Vasculature by Inducing PDGFRβ Shedding from Pericytes
por: Liu, Guanqiao, et al.
Publicado: (2023)

Acute impact of drinking coffee on the cerebral and systemic vasculature
por: Washio, Takuro, et al.
Publicado: (2017)

Quantitative Analysis of the Cerebral Vasculature on Magnetic Resonance Angiography
por: Goswami, Pulak, et al.
Publicado: (2020)

The importance of modeling the human cerebral vasculature in blunt trauma
por: Subramaniam, Dhananjay Radhakrishnan, et al.
Publicado: (2021)

Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency
por: Luciani, Alessandro, et al.
Publicado: (2020)

Impaired mitochondrial–endoplasmic reticulum interaction and mitophagy in Miro1-mutant neurons in Parkinson’s disease
por: Berenguer-Escuder, Clara, et al.
Publicado: (2020)

Nicotine Causes Mitochondrial Dynamics Imbalance and Apoptosis Through ROS Mediated Mitophagy Impairment in Cardiomyocytes
por: Meng, Ting-ting, et al.
Publicado: (2021)

Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis
por: Liu, Lei, et al.
Publicado: (2023)

Cigarette Smoke-Induced Cerebral Cortical Interleukin-6 Elevation is not Mediated Through Oxidative Stress
por: Lau, Way Kwok-Wai, et al.
Publicado: (2011)

Mitochondrial mitophagy in mesenteric artery remodeling in hyperhomocysteinemia
por: Familtseva, Anastasia, et al.
Publicado: (2014)

A Molecular Approach to Mitophagy and Mitochondrial Dynamics
por: Yoo, Seung-Min, et al.
Publicado: (2018)

Mitochondrial Function and Mitophagy in the Elderly: Effects of Exercise
por: Moreira, Osvaldo C., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_is8ip7c74ljf26qouvkio5tear