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Dysfunctional Mitochondrial Dynamic and Oxidative Phosphorylation Precedes Cardiac Dysfunction in R120G‐αB‐Crystallin‐Induced Desmin‐Related Cardiomyopathy

BACKGROUND: The mutated α‐B‐Crystallin (CryAB(R120G)) mouse model of desmin‐related myopathy (DRM) shows an age‐dependent onset of pathologic cardiac remodeling and progression of heart failure. CryAB(R120G) expression in cardiomyocytes affects the mitochondrial spatial organization within the myofi...

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Detalles Bibliográficos
Autores principales:	Alam, Shafiul, Abdullah, Chowdhury S., Aishwarya, Richa, Morshed, Mahboob, Nitu, Sadia S., Miriyala, Sumitra, Panchatcharam, Manikandan, Kevil, Christopher G., Orr, A. Wayne, Bhuiyan, Md. Shenuarin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763772/ https://www.ncbi.nlm.nih.gov/pubmed/33208022 http://dx.doi.org/10.1161/JAHA.120.017195

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