Plasminogen Deficiency and Amiloride Mitigate Angiotensin II–Induced Hypertension in Type 1 Diabetic Mice Suggesting Effects Through the Epithelial Sodium Channel

BACKGROUND: Diabetic nephropathy is a common diabetes mellitus complication associated with hypertension, proteinuria, and excretion of urinary plasmin that activates the epithelial sodium channel, ENaC, in vitro. Here we hypothesized that the deletion of plasminogen and amiloride treatment protect...

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Detalles Bibliográficos
Autores principales: Andersen, Henrik, Hansen, Maria Høj, Buhl, Kristian B., Stæhr, Mette, Friis, Ulla G., Enggaard, Camilla, Supramaniyam, Shanya, Lund, Ida K., Svenningsen, Per, Hansen, Pernille B. L., Jensen, Boye L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763785/
https://www.ncbi.nlm.nih.gov/pubmed/33215566
http://dx.doi.org/10.1161/JAHA.120.016387

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