Regeneration during Obesity: An Impaired Homeostasis

SIMPLE SUMMARY: Regeneration represents the biological processes that allow cells and tissues to renew and develop. During obesity, a variety of changes and reactions are seen. This includes inflammation and metabolic disorders. These obesity-induced changes do impact the regeneration processes. Such impacts that obesity has on regeneration would affect tissues and organs development and would also have consequences on the outcomes of therapies that depend on cells regeneration (such as burns, radiotherapy and leukemia) given to patients suffering from obesity. Therefore, a particular attention should be given to patients suffering from obesity in biological, therapeutic and clinical contexts that depend on regeneration ability. ABSTRACT: Obesity is a health problem that, in addition to the known morbidities, induces the generation of a biological environment with negative impacts on regeneration. Indeed, factors like DNA damages, oxidative stress and inflammation would impair the stem cell functions, in addition to some metabolic and development patterns. At the cellular and tissulaire levels, this has consequences on growth, renewal and restoration which results into an impaired regeneration. This impaired homeostasis concerns also key metabolic tissues including muscles and liver which would worsen the energy balance outcome towards further development of obesity. Such impacts of obesity on regeneration shows the need of a specific care given to obese patients recovering from diseases or conditions requiring regeneration such as burns, radiotherapy and leukemia. On the other hand, since stem cells are suggested to manage obesity, this impaired regeneration homeostasis needs to be considered towards more optimized stem cells-based obesity therapies within the context of precision medicine.