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Mechanisms of Resistance to Chemotherapy in Breast Cancer and Possible Targets in Drug Delivery Systems

Breast cancer (BC) is one of the most important cancers worldwide, and usually, chemotherapy can be used in an integrative approach. Usually, chemotherapy treatment is performed in association with surgery, radiation or hormone therapy, providing an increased outcome to patients. However, tumors can...

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Autores principales: Lainetti, Patrícia de Faria, Leis-Filho, Antonio Fernando, Laufer-Amorim, Renee, Battazza, Alexandre, Fonseca-Alves, Carlos Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763855/
https://www.ncbi.nlm.nih.gov/pubmed/33316872
http://dx.doi.org/10.3390/pharmaceutics12121193
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author Lainetti, Patrícia de Faria
Leis-Filho, Antonio Fernando
Laufer-Amorim, Renee
Battazza, Alexandre
Fonseca-Alves, Carlos Eduardo
author_facet Lainetti, Patrícia de Faria
Leis-Filho, Antonio Fernando
Laufer-Amorim, Renee
Battazza, Alexandre
Fonseca-Alves, Carlos Eduardo
author_sort Lainetti, Patrícia de Faria
collection PubMed
description Breast cancer (BC) is one of the most important cancers worldwide, and usually, chemotherapy can be used in an integrative approach. Usually, chemotherapy treatment is performed in association with surgery, radiation or hormone therapy, providing an increased outcome to patients. However, tumors can develop resistance to different drugs, progressing for a more aggressive phenotype. In this scenario, the use of nanocarriers could help to defeat tumor cell resistance, providing a new therapeutic perspective for patients. Thus, this systematic review aims to bring the molecular mechanisms involved in BC chemoresistance and extract from the previous literature information regarding the use of nanoparticles as potential treatment for chemoresistant breast cancer.
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spelling pubmed-77638552020-12-27 Mechanisms of Resistance to Chemotherapy in Breast Cancer and Possible Targets in Drug Delivery Systems Lainetti, Patrícia de Faria Leis-Filho, Antonio Fernando Laufer-Amorim, Renee Battazza, Alexandre Fonseca-Alves, Carlos Eduardo Pharmaceutics Review Breast cancer (BC) is one of the most important cancers worldwide, and usually, chemotherapy can be used in an integrative approach. Usually, chemotherapy treatment is performed in association with surgery, radiation or hormone therapy, providing an increased outcome to patients. However, tumors can develop resistance to different drugs, progressing for a more aggressive phenotype. In this scenario, the use of nanocarriers could help to defeat tumor cell resistance, providing a new therapeutic perspective for patients. Thus, this systematic review aims to bring the molecular mechanisms involved in BC chemoresistance and extract from the previous literature information regarding the use of nanoparticles as potential treatment for chemoresistant breast cancer. MDPI 2020-12-09 /pmc/articles/PMC7763855/ /pubmed/33316872 http://dx.doi.org/10.3390/pharmaceutics12121193 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lainetti, Patrícia de Faria
Leis-Filho, Antonio Fernando
Laufer-Amorim, Renee
Battazza, Alexandre
Fonseca-Alves, Carlos Eduardo
Mechanisms of Resistance to Chemotherapy in Breast Cancer and Possible Targets in Drug Delivery Systems
title Mechanisms of Resistance to Chemotherapy in Breast Cancer and Possible Targets in Drug Delivery Systems
title_full Mechanisms of Resistance to Chemotherapy in Breast Cancer and Possible Targets in Drug Delivery Systems
title_fullStr Mechanisms of Resistance to Chemotherapy in Breast Cancer and Possible Targets in Drug Delivery Systems
title_full_unstemmed Mechanisms of Resistance to Chemotherapy in Breast Cancer and Possible Targets in Drug Delivery Systems
title_short Mechanisms of Resistance to Chemotherapy in Breast Cancer and Possible Targets in Drug Delivery Systems
title_sort mechanisms of resistance to chemotherapy in breast cancer and possible targets in drug delivery systems
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763855/
https://www.ncbi.nlm.nih.gov/pubmed/33316872
http://dx.doi.org/10.3390/pharmaceutics12121193
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