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Mechanisms of Resistance to Chemotherapy in Breast Cancer and Possible Targets in Drug Delivery Systems
Breast cancer (BC) is one of the most important cancers worldwide, and usually, chemotherapy can be used in an integrative approach. Usually, chemotherapy treatment is performed in association with surgery, radiation or hormone therapy, providing an increased outcome to patients. However, tumors can...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763855/ https://www.ncbi.nlm.nih.gov/pubmed/33316872 http://dx.doi.org/10.3390/pharmaceutics12121193 |
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author | Lainetti, Patrícia de Faria Leis-Filho, Antonio Fernando Laufer-Amorim, Renee Battazza, Alexandre Fonseca-Alves, Carlos Eduardo |
author_facet | Lainetti, Patrícia de Faria Leis-Filho, Antonio Fernando Laufer-Amorim, Renee Battazza, Alexandre Fonseca-Alves, Carlos Eduardo |
author_sort | Lainetti, Patrícia de Faria |
collection | PubMed |
description | Breast cancer (BC) is one of the most important cancers worldwide, and usually, chemotherapy can be used in an integrative approach. Usually, chemotherapy treatment is performed in association with surgery, radiation or hormone therapy, providing an increased outcome to patients. However, tumors can develop resistance to different drugs, progressing for a more aggressive phenotype. In this scenario, the use of nanocarriers could help to defeat tumor cell resistance, providing a new therapeutic perspective for patients. Thus, this systematic review aims to bring the molecular mechanisms involved in BC chemoresistance and extract from the previous literature information regarding the use of nanoparticles as potential treatment for chemoresistant breast cancer. |
format | Online Article Text |
id | pubmed-7763855 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77638552020-12-27 Mechanisms of Resistance to Chemotherapy in Breast Cancer and Possible Targets in Drug Delivery Systems Lainetti, Patrícia de Faria Leis-Filho, Antonio Fernando Laufer-Amorim, Renee Battazza, Alexandre Fonseca-Alves, Carlos Eduardo Pharmaceutics Review Breast cancer (BC) is one of the most important cancers worldwide, and usually, chemotherapy can be used in an integrative approach. Usually, chemotherapy treatment is performed in association with surgery, radiation or hormone therapy, providing an increased outcome to patients. However, tumors can develop resistance to different drugs, progressing for a more aggressive phenotype. In this scenario, the use of nanocarriers could help to defeat tumor cell resistance, providing a new therapeutic perspective for patients. Thus, this systematic review aims to bring the molecular mechanisms involved in BC chemoresistance and extract from the previous literature information regarding the use of nanoparticles as potential treatment for chemoresistant breast cancer. MDPI 2020-12-09 /pmc/articles/PMC7763855/ /pubmed/33316872 http://dx.doi.org/10.3390/pharmaceutics12121193 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lainetti, Patrícia de Faria Leis-Filho, Antonio Fernando Laufer-Amorim, Renee Battazza, Alexandre Fonseca-Alves, Carlos Eduardo Mechanisms of Resistance to Chemotherapy in Breast Cancer and Possible Targets in Drug Delivery Systems |
title | Mechanisms of Resistance to Chemotherapy in Breast Cancer and Possible Targets in Drug Delivery Systems |
title_full | Mechanisms of Resistance to Chemotherapy in Breast Cancer and Possible Targets in Drug Delivery Systems |
title_fullStr | Mechanisms of Resistance to Chemotherapy in Breast Cancer and Possible Targets in Drug Delivery Systems |
title_full_unstemmed | Mechanisms of Resistance to Chemotherapy in Breast Cancer and Possible Targets in Drug Delivery Systems |
title_short | Mechanisms of Resistance to Chemotherapy in Breast Cancer and Possible Targets in Drug Delivery Systems |
title_sort | mechanisms of resistance to chemotherapy in breast cancer and possible targets in drug delivery systems |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763855/ https://www.ncbi.nlm.nih.gov/pubmed/33316872 http://dx.doi.org/10.3390/pharmaceutics12121193 |
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