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Physiologically Based Pharmacokinetic Modeling of Metoprolol Enantiomers and α-Hydroxymetoprolol to Describe CYP2D6 Drug-Gene Interactions

The beta-blocker metoprolol (the sixth most commonly prescribed drug in the USA in 2017) is subject to considerable drug–gene interaction (DGI) effects caused by genetic variations of the CYP2D6 gene. CYP2D6 poor metabolizers (5.7% of US population) show approximately five-fold higher metoprolol exp...

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Detalles Bibliográficos
Autores principales:	Rüdesheim, Simeon, Wojtyniak, Jan-Georg, Selzer, Dominik, Hanke, Nina, Mahfoud, Felix, Schwab, Matthias, Lehr, Thorsten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763912/ https://www.ncbi.nlm.nih.gov/pubmed/33322314 http://dx.doi.org/10.3390/pharmaceutics12121200

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