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Molecular Characterization of Constipation Disease as Novel Phenotypes in CRISPR-Cas9-Generated Leptin Knockout Mice with Obesity

(1) Background: We characterized a novel animal model with obesity-induced constipation because constipation is rarely known in genetically engineered mice (GEM); (2) Methods: The changes in the constipation parameters and mechanisms were analyzed in CRISPR-Cas9-mediated leptin (Lep) knockout (KO) m...

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Detalles Bibliográficos
Autores principales:	Kim, Ji Eun, Choi, Yun Ju, Lee, Su Jin, Gong, Jeong Eun, Lim, Yong, Hong, Jin Tae, Hwang, Dae Youn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763920/ https://www.ncbi.nlm.nih.gov/pubmed/33322729 http://dx.doi.org/10.3390/ijms21249464

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