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Are Follow-Up Blood Cultures Useful in the Antimicrobial Management of Gram Negative Bacteremia? A Reappraisal of Their Role Based on Current Knowledge

Bloodstream infections still constitute an outstanding cause of in-hospital morbidity and mortality, especially among critically ill patients. Follow up blood cultures (FUBCs) are widely recommended for proper management of Staphylococcus aureus and Candida spp. infections. On the other hand, their...

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Autores principales: Cogliati Dezza, Francesco, Curtolo, Ambrogio, Volpicelli, Lorenzo, Ceccarelli, Giancarlo, Oliva, Alessandra, Venditti, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764048/
https://www.ncbi.nlm.nih.gov/pubmed/33322549
http://dx.doi.org/10.3390/antibiotics9120895
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author Cogliati Dezza, Francesco
Curtolo, Ambrogio
Volpicelli, Lorenzo
Ceccarelli, Giancarlo
Oliva, Alessandra
Venditti, Mario
author_facet Cogliati Dezza, Francesco
Curtolo, Ambrogio
Volpicelli, Lorenzo
Ceccarelli, Giancarlo
Oliva, Alessandra
Venditti, Mario
author_sort Cogliati Dezza, Francesco
collection PubMed
description Bloodstream infections still constitute an outstanding cause of in-hospital morbidity and mortality, especially among critically ill patients. Follow up blood cultures (FUBCs) are widely recommended for proper management of Staphylococcus aureus and Candida spp. infections. On the other hand, their role is still a matter of controversy as far as Gram negative bacteremias are concerned. We revised, analyzed, and commented on the literature addressing this issue, to define the clinical settings in which the application of FUBCs could better reveal its value. The results of this review show that critically ill patients, endovascular and/or non-eradicable source of infection, isolation of a multi-drug resistant pathogen, end-stage renal disease, and immunodeficiencies are some factors that may predispose patients to persistent Gram negative bacteremia. An analysis of the different burdens that each of these factors have in this clinical setting allowed us to suggest which patients’ FUBCs have the potential to modify treatment choices, prompt an early source control, and finally, improve clinical outcome.
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spelling pubmed-77640482020-12-27 Are Follow-Up Blood Cultures Useful in the Antimicrobial Management of Gram Negative Bacteremia? A Reappraisal of Their Role Based on Current Knowledge Cogliati Dezza, Francesco Curtolo, Ambrogio Volpicelli, Lorenzo Ceccarelli, Giancarlo Oliva, Alessandra Venditti, Mario Antibiotics (Basel) Review Bloodstream infections still constitute an outstanding cause of in-hospital morbidity and mortality, especially among critically ill patients. Follow up blood cultures (FUBCs) are widely recommended for proper management of Staphylococcus aureus and Candida spp. infections. On the other hand, their role is still a matter of controversy as far as Gram negative bacteremias are concerned. We revised, analyzed, and commented on the literature addressing this issue, to define the clinical settings in which the application of FUBCs could better reveal its value. The results of this review show that critically ill patients, endovascular and/or non-eradicable source of infection, isolation of a multi-drug resistant pathogen, end-stage renal disease, and immunodeficiencies are some factors that may predispose patients to persistent Gram negative bacteremia. An analysis of the different burdens that each of these factors have in this clinical setting allowed us to suggest which patients’ FUBCs have the potential to modify treatment choices, prompt an early source control, and finally, improve clinical outcome. MDPI 2020-12-11 /pmc/articles/PMC7764048/ /pubmed/33322549 http://dx.doi.org/10.3390/antibiotics9120895 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cogliati Dezza, Francesco
Curtolo, Ambrogio
Volpicelli, Lorenzo
Ceccarelli, Giancarlo
Oliva, Alessandra
Venditti, Mario
Are Follow-Up Blood Cultures Useful in the Antimicrobial Management of Gram Negative Bacteremia? A Reappraisal of Their Role Based on Current Knowledge
title Are Follow-Up Blood Cultures Useful in the Antimicrobial Management of Gram Negative Bacteremia? A Reappraisal of Their Role Based on Current Knowledge
title_full Are Follow-Up Blood Cultures Useful in the Antimicrobial Management of Gram Negative Bacteremia? A Reappraisal of Their Role Based on Current Knowledge
title_fullStr Are Follow-Up Blood Cultures Useful in the Antimicrobial Management of Gram Negative Bacteremia? A Reappraisal of Their Role Based on Current Knowledge
title_full_unstemmed Are Follow-Up Blood Cultures Useful in the Antimicrobial Management of Gram Negative Bacteremia? A Reappraisal of Their Role Based on Current Knowledge
title_short Are Follow-Up Blood Cultures Useful in the Antimicrobial Management of Gram Negative Bacteremia? A Reappraisal of Their Role Based on Current Knowledge
title_sort are follow-up blood cultures useful in the antimicrobial management of gram negative bacteremia? a reappraisal of their role based on current knowledge
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764048/
https://www.ncbi.nlm.nih.gov/pubmed/33322549
http://dx.doi.org/10.3390/antibiotics9120895
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