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SARS-COV-2 Serological Profile in Healthcare Professionals of a Southern Italy Hospital
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the first coronavirus that has caused a pandemic. Assessing the prevalence of anti-SARS-CoV-2 in healthcare worker groups offers a unique opportunity to study the correlation between seroconversion and immunization because of their occu...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764094/ https://www.ncbi.nlm.nih.gov/pubmed/33322150 http://dx.doi.org/10.3390/ijerph17249324 |
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author | De Carlo, Armando Lo Caputo, Sergio Paolillo, Carmela Rosa, Anna Maria D’Orsi, Umberto De Palma, Maria Reveglia, Pierluigi Lacedonia, Donato Cinnella, Gilda Foschino, Maria Pia Margaglione, Maurizio Mirabella, Lucia Santantonio, Teresa Antonia Corso, Gaetano Dattoli, Vitangelo |
author_facet | De Carlo, Armando Lo Caputo, Sergio Paolillo, Carmela Rosa, Anna Maria D’Orsi, Umberto De Palma, Maria Reveglia, Pierluigi Lacedonia, Donato Cinnella, Gilda Foschino, Maria Pia Margaglione, Maurizio Mirabella, Lucia Santantonio, Teresa Antonia Corso, Gaetano Dattoli, Vitangelo |
author_sort | De Carlo, Armando |
collection | PubMed |
description | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the first coronavirus that has caused a pandemic. Assessing the prevalence of anti-SARS-CoV-2 in healthcare worker groups offers a unique opportunity to study the correlation between seroconversion and immunization because of their occupational exposure and a higher risk of contagion. The study enrolled 3242 asymptomatic employees of “Policlinico Riuniti”, Foggia. After the first screening, we collected sequential serum samples for up to 23 weeks from the same subjects. In order to perform a longitudinal follow-up study and get information about the titration of IgG levels, we analyzed data from subjects (33) with at least two consecutive serological IgG—positive tests; 62 (1.9%; 95% CI: 1.4–2.3) tested positive for at least one anti-SARS-CoV-2 antibody. The seroprevalence was lower in the high-risk group 1.4% (6/428; 95% CI: 0.5–2.6) vs. the intermediate-risk group 2.0% (55/2736; 95% CI: 1.5–2.5). Overall, within eight weeks, we detected a mean reduction of –17% in IgG levels. Our data suggest a reduction of about 9.27 AU/mL every week (R(2) = 0.35, p = 0.0003). This study revealed the prevalence of SARS-CoV-2 antibodies among Foggia’s hospital healthcare staff (1.9%). Moreover, the IgG level reduction suggests that the serological response fades fast in asymptomatic infections. |
format | Online Article Text |
id | pubmed-7764094 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77640942020-12-27 SARS-COV-2 Serological Profile in Healthcare Professionals of a Southern Italy Hospital De Carlo, Armando Lo Caputo, Sergio Paolillo, Carmela Rosa, Anna Maria D’Orsi, Umberto De Palma, Maria Reveglia, Pierluigi Lacedonia, Donato Cinnella, Gilda Foschino, Maria Pia Margaglione, Maurizio Mirabella, Lucia Santantonio, Teresa Antonia Corso, Gaetano Dattoli, Vitangelo Int J Environ Res Public Health Article Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the first coronavirus that has caused a pandemic. Assessing the prevalence of anti-SARS-CoV-2 in healthcare worker groups offers a unique opportunity to study the correlation between seroconversion and immunization because of their occupational exposure and a higher risk of contagion. The study enrolled 3242 asymptomatic employees of “Policlinico Riuniti”, Foggia. After the first screening, we collected sequential serum samples for up to 23 weeks from the same subjects. In order to perform a longitudinal follow-up study and get information about the titration of IgG levels, we analyzed data from subjects (33) with at least two consecutive serological IgG—positive tests; 62 (1.9%; 95% CI: 1.4–2.3) tested positive for at least one anti-SARS-CoV-2 antibody. The seroprevalence was lower in the high-risk group 1.4% (6/428; 95% CI: 0.5–2.6) vs. the intermediate-risk group 2.0% (55/2736; 95% CI: 1.5–2.5). Overall, within eight weeks, we detected a mean reduction of –17% in IgG levels. Our data suggest a reduction of about 9.27 AU/mL every week (R(2) = 0.35, p = 0.0003). This study revealed the prevalence of SARS-CoV-2 antibodies among Foggia’s hospital healthcare staff (1.9%). Moreover, the IgG level reduction suggests that the serological response fades fast in asymptomatic infections. MDPI 2020-12-13 2020-12 /pmc/articles/PMC7764094/ /pubmed/33322150 http://dx.doi.org/10.3390/ijerph17249324 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article De Carlo, Armando Lo Caputo, Sergio Paolillo, Carmela Rosa, Anna Maria D’Orsi, Umberto De Palma, Maria Reveglia, Pierluigi Lacedonia, Donato Cinnella, Gilda Foschino, Maria Pia Margaglione, Maurizio Mirabella, Lucia Santantonio, Teresa Antonia Corso, Gaetano Dattoli, Vitangelo SARS-COV-2 Serological Profile in Healthcare Professionals of a Southern Italy Hospital |
title | SARS-COV-2 Serological Profile in Healthcare Professionals of a Southern Italy Hospital |
title_full | SARS-COV-2 Serological Profile in Healthcare Professionals of a Southern Italy Hospital |
title_fullStr | SARS-COV-2 Serological Profile in Healthcare Professionals of a Southern Italy Hospital |
title_full_unstemmed | SARS-COV-2 Serological Profile in Healthcare Professionals of a Southern Italy Hospital |
title_short | SARS-COV-2 Serological Profile in Healthcare Professionals of a Southern Italy Hospital |
title_sort | sars-cov-2 serological profile in healthcare professionals of a southern italy hospital |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764094/ https://www.ncbi.nlm.nih.gov/pubmed/33322150 http://dx.doi.org/10.3390/ijerph17249324 |
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