Circulating Tumour DNA Sequencing Identifies a Genetic Resistance-Gap in Colorectal Cancers with Acquired Resistance to EGFR-Antibodies and Chemotherapy

SIMPLE SUMMARY: Recent studies have shown the potential of next generation sequencing (NGS) for the identification of genetic variants in tumour DNA that has been released into the bloodstream (ctDNA). However, such variants are often rare in the sample and error correction is required to filter out...

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Detalles Bibliográficos
Autores principales: Knebel, Franciele H., Barber, Louise J., Newey, Alice, Kleftogiannis, Dimitrios, Woolston, Andrew, Griffiths, Beatrice, Fenwick, Kerry, Bettoni, Fabiana, Ribeiro, Maurício Fernando Silva Almeida, da Fonseca, Leonardo, Costa, Frederico, Capareli, Fernanda Cunha, Hoff, Paulo M., Sabbaga, Jorge, Camargo, Anamaria A., Gerlinger, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764102/
https://www.ncbi.nlm.nih.gov/pubmed/33322618
http://dx.doi.org/10.3390/cancers12123736

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