Liposomes Targeting P21 Activated Kinase-1 (PAK-1) and Selective for Secretory Phospholipase A(2) (sPLA(2)) Decrease Cell Viability and Induce Apoptosis in Metastatic Triple-Negative Breast Cancer Cells

P21 activated kinases (or group I PAKs) are serine/threonine kinases whose expression is altered in prostate and breast cancers. PAK-1 activity is inhibited by the small molecule “Inhibitor targeting PAK-1 activation-3” (IPA-3), which has selectivity for PAK-1 but is metabolically unstable. Secretor...

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Detalles Bibliográficos
Autores principales: Najahi-Missaoui, Wided, Quach, Nhat D., Somanath, Payaningal R., Cummings, Brian S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764208/
https://www.ncbi.nlm.nih.gov/pubmed/33321758
http://dx.doi.org/10.3390/ijms21249396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764208/
https://www.ncbi.nlm.nih.gov/pubmed/33321758
http://dx.doi.org/10.3390/ijms21249396

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