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Primary Breast Extranodal Marginal Zone Lymphoma in Primary Sjögren Syndrome: Case Presentation and Relevant Literature
The association between autoimmune diseases, mostly rheumatoid arthritis, systemic lupus erythematosus, celiac disease and Sjögren syndrome, and lymphoma, has been widely demonstrated by several epidemiologic studies. By a mechanism which has not yet been entirely elucidated, chronic activation/stim...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764276/ https://www.ncbi.nlm.nih.gov/pubmed/33321727 http://dx.doi.org/10.3390/jcm9123997 |
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author | Ingravallo, Giuseppe Maiorano, Eugenio Moschetta, Marco Limongelli, Luisa Mastropasqua, Mauro Giuseppe Agazzino, Gisella Franca De Ruvo, Vincenzo Tarantino, Paola Favia, Gianfranco Capodiferro, Saverio |
author_facet | Ingravallo, Giuseppe Maiorano, Eugenio Moschetta, Marco Limongelli, Luisa Mastropasqua, Mauro Giuseppe Agazzino, Gisella Franca De Ruvo, Vincenzo Tarantino, Paola Favia, Gianfranco Capodiferro, Saverio |
author_sort | Ingravallo, Giuseppe |
collection | PubMed |
description | The association between autoimmune diseases, mostly rheumatoid arthritis, systemic lupus erythematosus, celiac disease and Sjögren syndrome, and lymphoma, has been widely demonstrated by several epidemiologic studies. By a mechanism which has not yet been entirely elucidated, chronic activation/stimulation of the immune system, along with the administration of specific treatments, may lead to the onset of different types of lymphoma in such patients. Specifically, patients affected by Sjögren syndrome may develop lymphomas many years after the original diagnosis. Several epidemiologic, hematologic, and histological features may anticipate the progression from Sjögren syndrome into lymphoma but, to the best of our knowledge, a definite pathogenetic mechanism for such progression is still missing. In fact, while the association between Sjögren syndrome and non-Hodgkin lymphoma, mostly extranodal marginal zone lymphomas and, less often, diffuse large B-cell, is well established, many other variables, such as time of onset, gender predilection, sites of occurrence, subtype of lymphoma, and predictive factors, still remain unclear. We report on a rare case of primary breast lymphoma occurring three years after the diagnosis of Sjögren syndrome in a 57-year-old patient. The diagnostic work-up, including radiograms, core needle biopsy, and histological examination, is discussed, along with emerging data from the recent literature, thus highlighting the usefulness of breast surveillance in Sjögren syndrome patients. |
format | Online Article Text |
id | pubmed-7764276 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77642762020-12-27 Primary Breast Extranodal Marginal Zone Lymphoma in Primary Sjögren Syndrome: Case Presentation and Relevant Literature Ingravallo, Giuseppe Maiorano, Eugenio Moschetta, Marco Limongelli, Luisa Mastropasqua, Mauro Giuseppe Agazzino, Gisella Franca De Ruvo, Vincenzo Tarantino, Paola Favia, Gianfranco Capodiferro, Saverio J Clin Med Article The association between autoimmune diseases, mostly rheumatoid arthritis, systemic lupus erythematosus, celiac disease and Sjögren syndrome, and lymphoma, has been widely demonstrated by several epidemiologic studies. By a mechanism which has not yet been entirely elucidated, chronic activation/stimulation of the immune system, along with the administration of specific treatments, may lead to the onset of different types of lymphoma in such patients. Specifically, patients affected by Sjögren syndrome may develop lymphomas many years after the original diagnosis. Several epidemiologic, hematologic, and histological features may anticipate the progression from Sjögren syndrome into lymphoma but, to the best of our knowledge, a definite pathogenetic mechanism for such progression is still missing. In fact, while the association between Sjögren syndrome and non-Hodgkin lymphoma, mostly extranodal marginal zone lymphomas and, less often, diffuse large B-cell, is well established, many other variables, such as time of onset, gender predilection, sites of occurrence, subtype of lymphoma, and predictive factors, still remain unclear. We report on a rare case of primary breast lymphoma occurring three years after the diagnosis of Sjögren syndrome in a 57-year-old patient. The diagnostic work-up, including radiograms, core needle biopsy, and histological examination, is discussed, along with emerging data from the recent literature, thus highlighting the usefulness of breast surveillance in Sjögren syndrome patients. MDPI 2020-12-10 /pmc/articles/PMC7764276/ /pubmed/33321727 http://dx.doi.org/10.3390/jcm9123997 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ingravallo, Giuseppe Maiorano, Eugenio Moschetta, Marco Limongelli, Luisa Mastropasqua, Mauro Giuseppe Agazzino, Gisella Franca De Ruvo, Vincenzo Tarantino, Paola Favia, Gianfranco Capodiferro, Saverio Primary Breast Extranodal Marginal Zone Lymphoma in Primary Sjögren Syndrome: Case Presentation and Relevant Literature |
title | Primary Breast Extranodal Marginal Zone Lymphoma in Primary Sjögren Syndrome: Case Presentation and Relevant Literature |
title_full | Primary Breast Extranodal Marginal Zone Lymphoma in Primary Sjögren Syndrome: Case Presentation and Relevant Literature |
title_fullStr | Primary Breast Extranodal Marginal Zone Lymphoma in Primary Sjögren Syndrome: Case Presentation and Relevant Literature |
title_full_unstemmed | Primary Breast Extranodal Marginal Zone Lymphoma in Primary Sjögren Syndrome: Case Presentation and Relevant Literature |
title_short | Primary Breast Extranodal Marginal Zone Lymphoma in Primary Sjögren Syndrome: Case Presentation and Relevant Literature |
title_sort | primary breast extranodal marginal zone lymphoma in primary sjögren syndrome: case presentation and relevant literature |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764276/ https://www.ncbi.nlm.nih.gov/pubmed/33321727 http://dx.doi.org/10.3390/jcm9123997 |
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