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The Close Relationship between the Golgi Trafficking Machinery and Protein Glycosylation
Glycosylation is the most common post-translational modification of proteins; it mediates their correct folding and stability, as well as their transport through the secretory transport. Changes in N- and O-linked glycans have been associated with multiple pathological conditions including congenita...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764369/ https://www.ncbi.nlm.nih.gov/pubmed/33321764 http://dx.doi.org/10.3390/cells9122652 |
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author | Frappaolo, Anna Karimpour-Ghahnavieh, Angela Sechi, Stefano Giansanti, Maria Grazia |
author_facet | Frappaolo, Anna Karimpour-Ghahnavieh, Angela Sechi, Stefano Giansanti, Maria Grazia |
author_sort | Frappaolo, Anna |
collection | PubMed |
description | Glycosylation is the most common post-translational modification of proteins; it mediates their correct folding and stability, as well as their transport through the secretory transport. Changes in N- and O-linked glycans have been associated with multiple pathological conditions including congenital disorders of glycosylation, inflammatory diseases and cancer. Glycoprotein glycosylation at the Golgi involves the coordinated action of hundreds of glycosyltransferases and glycosidases, which are maintained at the correct location through retrograde vesicle trafficking between Golgi cisternae. In this review, we describe the molecular machinery involved in vesicle trafficking and tethering at the Golgi apparatus and the effects of mutations in the context of glycan biosynthesis and human diseases. |
format | Online Article Text |
id | pubmed-7764369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77643692020-12-27 The Close Relationship between the Golgi Trafficking Machinery and Protein Glycosylation Frappaolo, Anna Karimpour-Ghahnavieh, Angela Sechi, Stefano Giansanti, Maria Grazia Cells Review Glycosylation is the most common post-translational modification of proteins; it mediates their correct folding and stability, as well as their transport through the secretory transport. Changes in N- and O-linked glycans have been associated with multiple pathological conditions including congenital disorders of glycosylation, inflammatory diseases and cancer. Glycoprotein glycosylation at the Golgi involves the coordinated action of hundreds of glycosyltransferases and glycosidases, which are maintained at the correct location through retrograde vesicle trafficking between Golgi cisternae. In this review, we describe the molecular machinery involved in vesicle trafficking and tethering at the Golgi apparatus and the effects of mutations in the context of glycan biosynthesis and human diseases. MDPI 2020-12-10 /pmc/articles/PMC7764369/ /pubmed/33321764 http://dx.doi.org/10.3390/cells9122652 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Frappaolo, Anna Karimpour-Ghahnavieh, Angela Sechi, Stefano Giansanti, Maria Grazia The Close Relationship between the Golgi Trafficking Machinery and Protein Glycosylation |
title | The Close Relationship between the Golgi Trafficking Machinery and Protein Glycosylation |
title_full | The Close Relationship between the Golgi Trafficking Machinery and Protein Glycosylation |
title_fullStr | The Close Relationship between the Golgi Trafficking Machinery and Protein Glycosylation |
title_full_unstemmed | The Close Relationship between the Golgi Trafficking Machinery and Protein Glycosylation |
title_short | The Close Relationship between the Golgi Trafficking Machinery and Protein Glycosylation |
title_sort | close relationship between the golgi trafficking machinery and protein glycosylation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764369/ https://www.ncbi.nlm.nih.gov/pubmed/33321764 http://dx.doi.org/10.3390/cells9122652 |
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