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Retinoic Acid and Its Derivatives in Skin

The retinoids are a group of compounds including vitamin A and its active metabolite all-trans-retinoic acid (ATRA). Retinoids regulate a variety of physiological functions in multiple organ systems, are essential for normal immune competence, and are involved in the regulation of cell growth and di...

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Autores principales: Szymański, Łukasz, Skopek, Rafał, Palusińska, Małgorzata, Schenk, Tino, Stengel, Sven, Lewicki, Sławomir, Kraj, Leszek, Kamiński, Paweł, Zelent, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764495/
https://www.ncbi.nlm.nih.gov/pubmed/33322246
http://dx.doi.org/10.3390/cells9122660
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author Szymański, Łukasz
Skopek, Rafał
Palusińska, Małgorzata
Schenk, Tino
Stengel, Sven
Lewicki, Sławomir
Kraj, Leszek
Kamiński, Paweł
Zelent, Arthur
author_facet Szymański, Łukasz
Skopek, Rafał
Palusińska, Małgorzata
Schenk, Tino
Stengel, Sven
Lewicki, Sławomir
Kraj, Leszek
Kamiński, Paweł
Zelent, Arthur
author_sort Szymański, Łukasz
collection PubMed
description The retinoids are a group of compounds including vitamin A and its active metabolite all-trans-retinoic acid (ATRA). Retinoids regulate a variety of physiological functions in multiple organ systems, are essential for normal immune competence, and are involved in the regulation of cell growth and differentiation. Vitamin A derivatives have held promise in cancer treatment and ATRA is used in differentiation therapy of acute promyelocytic leukemia (APL). ATRA and other retinoids have also been successfully applied in a variety of dermatological conditions such as skin cancer, psoriasis, acne, and ichthyosis. Moreover, modulation of retinoic acid receptors and retinoid X (or rexinoid) receptors function may affect dermal cells. The studies using complex genetic models with various combinations of retinoic acid receptors (RARs) and retinoid X (or rexinoid) receptors (RXRs) indicate that retinoic acid and its derivatives have therapeutic potential for a variety of serious dermatological disorders including some malignant conditions. Here, we provide a synopsis of the main advances in understanding the role of ATRA and its receptors in dermatology.
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spelling pubmed-77644952020-12-27 Retinoic Acid and Its Derivatives in Skin Szymański, Łukasz Skopek, Rafał Palusińska, Małgorzata Schenk, Tino Stengel, Sven Lewicki, Sławomir Kraj, Leszek Kamiński, Paweł Zelent, Arthur Cells Review The retinoids are a group of compounds including vitamin A and its active metabolite all-trans-retinoic acid (ATRA). Retinoids regulate a variety of physiological functions in multiple organ systems, are essential for normal immune competence, and are involved in the regulation of cell growth and differentiation. Vitamin A derivatives have held promise in cancer treatment and ATRA is used in differentiation therapy of acute promyelocytic leukemia (APL). ATRA and other retinoids have also been successfully applied in a variety of dermatological conditions such as skin cancer, psoriasis, acne, and ichthyosis. Moreover, modulation of retinoic acid receptors and retinoid X (or rexinoid) receptors function may affect dermal cells. The studies using complex genetic models with various combinations of retinoic acid receptors (RARs) and retinoid X (or rexinoid) receptors (RXRs) indicate that retinoic acid and its derivatives have therapeutic potential for a variety of serious dermatological disorders including some malignant conditions. Here, we provide a synopsis of the main advances in understanding the role of ATRA and its receptors in dermatology. MDPI 2020-12-11 /pmc/articles/PMC7764495/ /pubmed/33322246 http://dx.doi.org/10.3390/cells9122660 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Szymański, Łukasz
Skopek, Rafał
Palusińska, Małgorzata
Schenk, Tino
Stengel, Sven
Lewicki, Sławomir
Kraj, Leszek
Kamiński, Paweł
Zelent, Arthur
Retinoic Acid and Its Derivatives in Skin
title Retinoic Acid and Its Derivatives in Skin
title_full Retinoic Acid and Its Derivatives in Skin
title_fullStr Retinoic Acid and Its Derivatives in Skin
title_full_unstemmed Retinoic Acid and Its Derivatives in Skin
title_short Retinoic Acid and Its Derivatives in Skin
title_sort retinoic acid and its derivatives in skin
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764495/
https://www.ncbi.nlm.nih.gov/pubmed/33322246
http://dx.doi.org/10.3390/cells9122660
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