Cargando…

Styrylpyrazoles: Properties, Synthesis and Transformations

The pyrazole nucleus and its reduced forms, pyrazolines and pyrazolidine, are privileged scaffolds in medicinal chemistry due to their remarkable biological activities. A huge number of pyrazole derivatives have been studied and reported over time. This review article gives an overview of pyrazole d...

Descripción completa

Detalles Bibliográficos
Autores principales: Gomes, Pedro M. O., Ouro, Pedro M. S., Silva, Artur M. S., Silva, Vera L. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764498/
https://www.ncbi.nlm.nih.gov/pubmed/33322752
http://dx.doi.org/10.3390/molecules25245886
_version_ 1783628271555969024
author Gomes, Pedro M. O.
Ouro, Pedro M. S.
Silva, Artur M. S.
Silva, Vera L. M.
author_facet Gomes, Pedro M. O.
Ouro, Pedro M. S.
Silva, Artur M. S.
Silva, Vera L. M.
author_sort Gomes, Pedro M. O.
collection PubMed
description The pyrazole nucleus and its reduced forms, pyrazolines and pyrazolidine, are privileged scaffolds in medicinal chemistry due to their remarkable biological activities. A huge number of pyrazole derivatives have been studied and reported over time. This review article gives an overview of pyrazole derivatives that contain a styryl (2-arylvinyl) group linked in different positions of the pyrazole backbone. Although there are studies on the synthesis of styrylpyrazoles dating back to the 1970s and even earlier, this type of compound has rarely been studied. This timely review intends to summarize the properties, biological activity, methods of synthesis and transformation of styrylpyrazoles; thus, highlighting the interest and huge potential for application of this kind of compound.
format Online
Article
Text
id pubmed-7764498
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-77644982020-12-27 Styrylpyrazoles: Properties, Synthesis and Transformations Gomes, Pedro M. O. Ouro, Pedro M. S. Silva, Artur M. S. Silva, Vera L. M. Molecules Review The pyrazole nucleus and its reduced forms, pyrazolines and pyrazolidine, are privileged scaffolds in medicinal chemistry due to their remarkable biological activities. A huge number of pyrazole derivatives have been studied and reported over time. This review article gives an overview of pyrazole derivatives that contain a styryl (2-arylvinyl) group linked in different positions of the pyrazole backbone. Although there are studies on the synthesis of styrylpyrazoles dating back to the 1970s and even earlier, this type of compound has rarely been studied. This timely review intends to summarize the properties, biological activity, methods of synthesis and transformation of styrylpyrazoles; thus, highlighting the interest and huge potential for application of this kind of compound. MDPI 2020-12-12 /pmc/articles/PMC7764498/ /pubmed/33322752 http://dx.doi.org/10.3390/molecules25245886 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gomes, Pedro M. O.
Ouro, Pedro M. S.
Silva, Artur M. S.
Silva, Vera L. M.
Styrylpyrazoles: Properties, Synthesis and Transformations
title Styrylpyrazoles: Properties, Synthesis and Transformations
title_full Styrylpyrazoles: Properties, Synthesis and Transformations
title_fullStr Styrylpyrazoles: Properties, Synthesis and Transformations
title_full_unstemmed Styrylpyrazoles: Properties, Synthesis and Transformations
title_short Styrylpyrazoles: Properties, Synthesis and Transformations
title_sort styrylpyrazoles: properties, synthesis and transformations
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764498/
https://www.ncbi.nlm.nih.gov/pubmed/33322752
http://dx.doi.org/10.3390/molecules25245886
work_keys_str_mv AT gomespedromo styrylpyrazolespropertiessynthesisandtransformations
AT ouropedroms styrylpyrazolespropertiessynthesisandtransformations
AT silvaarturms styrylpyrazolespropertiessynthesisandtransformations
AT silvaveralm styrylpyrazolespropertiessynthesisandtransformations