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Styrylpyrazoles: Properties, Synthesis and Transformations
The pyrazole nucleus and its reduced forms, pyrazolines and pyrazolidine, are privileged scaffolds in medicinal chemistry due to their remarkable biological activities. A huge number of pyrazole derivatives have been studied and reported over time. This review article gives an overview of pyrazole d...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764498/ https://www.ncbi.nlm.nih.gov/pubmed/33322752 http://dx.doi.org/10.3390/molecules25245886 |
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author | Gomes, Pedro M. O. Ouro, Pedro M. S. Silva, Artur M. S. Silva, Vera L. M. |
author_facet | Gomes, Pedro M. O. Ouro, Pedro M. S. Silva, Artur M. S. Silva, Vera L. M. |
author_sort | Gomes, Pedro M. O. |
collection | PubMed |
description | The pyrazole nucleus and its reduced forms, pyrazolines and pyrazolidine, are privileged scaffolds in medicinal chemistry due to their remarkable biological activities. A huge number of pyrazole derivatives have been studied and reported over time. This review article gives an overview of pyrazole derivatives that contain a styryl (2-arylvinyl) group linked in different positions of the pyrazole backbone. Although there are studies on the synthesis of styrylpyrazoles dating back to the 1970s and even earlier, this type of compound has rarely been studied. This timely review intends to summarize the properties, biological activity, methods of synthesis and transformation of styrylpyrazoles; thus, highlighting the interest and huge potential for application of this kind of compound. |
format | Online Article Text |
id | pubmed-7764498 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77644982020-12-27 Styrylpyrazoles: Properties, Synthesis and Transformations Gomes, Pedro M. O. Ouro, Pedro M. S. Silva, Artur M. S. Silva, Vera L. M. Molecules Review The pyrazole nucleus and its reduced forms, pyrazolines and pyrazolidine, are privileged scaffolds in medicinal chemistry due to their remarkable biological activities. A huge number of pyrazole derivatives have been studied and reported over time. This review article gives an overview of pyrazole derivatives that contain a styryl (2-arylvinyl) group linked in different positions of the pyrazole backbone. Although there are studies on the synthesis of styrylpyrazoles dating back to the 1970s and even earlier, this type of compound has rarely been studied. This timely review intends to summarize the properties, biological activity, methods of synthesis and transformation of styrylpyrazoles; thus, highlighting the interest and huge potential for application of this kind of compound. MDPI 2020-12-12 /pmc/articles/PMC7764498/ /pubmed/33322752 http://dx.doi.org/10.3390/molecules25245886 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gomes, Pedro M. O. Ouro, Pedro M. S. Silva, Artur M. S. Silva, Vera L. M. Styrylpyrazoles: Properties, Synthesis and Transformations |
title | Styrylpyrazoles: Properties, Synthesis and Transformations |
title_full | Styrylpyrazoles: Properties, Synthesis and Transformations |
title_fullStr | Styrylpyrazoles: Properties, Synthesis and Transformations |
title_full_unstemmed | Styrylpyrazoles: Properties, Synthesis and Transformations |
title_short | Styrylpyrazoles: Properties, Synthesis and Transformations |
title_sort | styrylpyrazoles: properties, synthesis and transformations |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764498/ https://www.ncbi.nlm.nih.gov/pubmed/33322752 http://dx.doi.org/10.3390/molecules25245886 |
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