Cargando…

Magnetic Imaging of Encapsulated Superparamagnetic Nanoparticles by Data Fusion of Magnetic Force Microscopy and Atomic Force Microscopy Signals for Correction of Topographic Crosstalk

Encapsulated magnetic nanoparticles are of increasing interest for biomedical applications. However, up to now, it is still not possible to characterize their localized magnetic properties within the capsules. Magnetic Force Microscopy (MFM) has proved to be a suitable technique to image magnetic na...

Descripción completa

Detalles Bibliográficos
Autores principales: Fuhrmann, Marc, Musyanovych, Anna, Thoelen, Ronald, von Bomhard, Sibylle, Möbius, Hildegard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764545/
https://www.ncbi.nlm.nih.gov/pubmed/33322271
http://dx.doi.org/10.3390/nano10122486
_version_ 1783628282782023680
author Fuhrmann, Marc
Musyanovych, Anna
Thoelen, Ronald
von Bomhard, Sibylle
Möbius, Hildegard
author_facet Fuhrmann, Marc
Musyanovych, Anna
Thoelen, Ronald
von Bomhard, Sibylle
Möbius, Hildegard
author_sort Fuhrmann, Marc
collection PubMed
description Encapsulated magnetic nanoparticles are of increasing interest for biomedical applications. However, up to now, it is still not possible to characterize their localized magnetic properties within the capsules. Magnetic Force Microscopy (MFM) has proved to be a suitable technique to image magnetic nanoparticles at ambient conditions revealing information about the spatial distribution and the magnetic properties of the nanoparticles simultaneously. However, MFM measurements on magnetic nanoparticles lead to falsifications of the magnetic MFM signal due to the topographic crosstalk. The origin of the topographic crosstalk in MFM has been proven to be capacitive coupling effects due to distance change between the substrate and tip measuring above the nanoparticle. In this paper, we present data fusion of the topography measurements of Atomic Force Microscopy (AFM) and the phase image of MFM measurements in combination with the theory of capacitive coupling in order to eliminate the topographic crosstalk in the phase image. This method offers a novel approach for the magnetic visualization of encapsulated magnetic nanoparticles.
format Online
Article
Text
id pubmed-7764545
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-77645452020-12-27 Magnetic Imaging of Encapsulated Superparamagnetic Nanoparticles by Data Fusion of Magnetic Force Microscopy and Atomic Force Microscopy Signals for Correction of Topographic Crosstalk Fuhrmann, Marc Musyanovych, Anna Thoelen, Ronald von Bomhard, Sibylle Möbius, Hildegard Nanomaterials (Basel) Article Encapsulated magnetic nanoparticles are of increasing interest for biomedical applications. However, up to now, it is still not possible to characterize their localized magnetic properties within the capsules. Magnetic Force Microscopy (MFM) has proved to be a suitable technique to image magnetic nanoparticles at ambient conditions revealing information about the spatial distribution and the magnetic properties of the nanoparticles simultaneously. However, MFM measurements on magnetic nanoparticles lead to falsifications of the magnetic MFM signal due to the topographic crosstalk. The origin of the topographic crosstalk in MFM has been proven to be capacitive coupling effects due to distance change between the substrate and tip measuring above the nanoparticle. In this paper, we present data fusion of the topography measurements of Atomic Force Microscopy (AFM) and the phase image of MFM measurements in combination with the theory of capacitive coupling in order to eliminate the topographic crosstalk in the phase image. This method offers a novel approach for the magnetic visualization of encapsulated magnetic nanoparticles. MDPI 2020-12-11 /pmc/articles/PMC7764545/ /pubmed/33322271 http://dx.doi.org/10.3390/nano10122486 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fuhrmann, Marc
Musyanovych, Anna
Thoelen, Ronald
von Bomhard, Sibylle
Möbius, Hildegard
Magnetic Imaging of Encapsulated Superparamagnetic Nanoparticles by Data Fusion of Magnetic Force Microscopy and Atomic Force Microscopy Signals for Correction of Topographic Crosstalk
title Magnetic Imaging of Encapsulated Superparamagnetic Nanoparticles by Data Fusion of Magnetic Force Microscopy and Atomic Force Microscopy Signals for Correction of Topographic Crosstalk
title_full Magnetic Imaging of Encapsulated Superparamagnetic Nanoparticles by Data Fusion of Magnetic Force Microscopy and Atomic Force Microscopy Signals for Correction of Topographic Crosstalk
title_fullStr Magnetic Imaging of Encapsulated Superparamagnetic Nanoparticles by Data Fusion of Magnetic Force Microscopy and Atomic Force Microscopy Signals for Correction of Topographic Crosstalk
title_full_unstemmed Magnetic Imaging of Encapsulated Superparamagnetic Nanoparticles by Data Fusion of Magnetic Force Microscopy and Atomic Force Microscopy Signals for Correction of Topographic Crosstalk
title_short Magnetic Imaging of Encapsulated Superparamagnetic Nanoparticles by Data Fusion of Magnetic Force Microscopy and Atomic Force Microscopy Signals for Correction of Topographic Crosstalk
title_sort magnetic imaging of encapsulated superparamagnetic nanoparticles by data fusion of magnetic force microscopy and atomic force microscopy signals for correction of topographic crosstalk
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764545/
https://www.ncbi.nlm.nih.gov/pubmed/33322271
http://dx.doi.org/10.3390/nano10122486
work_keys_str_mv AT fuhrmannmarc magneticimagingofencapsulatedsuperparamagneticnanoparticlesbydatafusionofmagneticforcemicroscopyandatomicforcemicroscopysignalsforcorrectionoftopographiccrosstalk
AT musyanovychanna magneticimagingofencapsulatedsuperparamagneticnanoparticlesbydatafusionofmagneticforcemicroscopyandatomicforcemicroscopysignalsforcorrectionoftopographiccrosstalk
AT thoelenronald magneticimagingofencapsulatedsuperparamagneticnanoparticlesbydatafusionofmagneticforcemicroscopyandatomicforcemicroscopysignalsforcorrectionoftopographiccrosstalk
AT vonbomhardsibylle magneticimagingofencapsulatedsuperparamagneticnanoparticlesbydatafusionofmagneticforcemicroscopyandatomicforcemicroscopysignalsforcorrectionoftopographiccrosstalk
AT mobiushildegard magneticimagingofencapsulatedsuperparamagneticnanoparticlesbydatafusionofmagneticforcemicroscopyandatomicforcemicroscopysignalsforcorrectionoftopographiccrosstalk