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The Role of Nucleoporin Elys in Nuclear Pore Complex Assembly and Regulation of Genome Architecture

For a long time, the nuclear lamina was thought to be the sole scaffold for the attachment of chromosomes to the nuclear envelope (NE) in metazoans. However, accumulating evidence indicates that nuclear pore complexes (NPCs) comprised of nucleoporins (Nups) participate in this process as well. One o...

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Autor principal: Shevelyov, Yuri Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764596/
https://www.ncbi.nlm.nih.gov/pubmed/33322130
http://dx.doi.org/10.3390/ijms21249475
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author Shevelyov, Yuri Y.
author_facet Shevelyov, Yuri Y.
author_sort Shevelyov, Yuri Y.
collection PubMed
description For a long time, the nuclear lamina was thought to be the sole scaffold for the attachment of chromosomes to the nuclear envelope (NE) in metazoans. However, accumulating evidence indicates that nuclear pore complexes (NPCs) comprised of nucleoporins (Nups) participate in this process as well. One of the Nups, Elys, initiates NPC reassembly at the end of mitosis. Elys directly binds the decondensing chromatin and interacts with the Nup107–160 subcomplex of NPCs, thus serving as a seeding point for the subsequent recruitment of other NPC subcomplexes and connecting chromatin with the re-forming NE. Recent studies also uncovered the important functions of Elys during interphase where it interacts with chromatin and affects its compactness. Therefore, Elys seems to be one of the key Nups regulating chromatin organization. This review summarizes the current state of our knowledge about the participation of Elys in the post-mitotic NPC reassembly as well as the role that Elys and other Nups play in the maintenance of genome architecture.
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spelling pubmed-77645962020-12-27 The Role of Nucleoporin Elys in Nuclear Pore Complex Assembly and Regulation of Genome Architecture Shevelyov, Yuri Y. Int J Mol Sci Review For a long time, the nuclear lamina was thought to be the sole scaffold for the attachment of chromosomes to the nuclear envelope (NE) in metazoans. However, accumulating evidence indicates that nuclear pore complexes (NPCs) comprised of nucleoporins (Nups) participate in this process as well. One of the Nups, Elys, initiates NPC reassembly at the end of mitosis. Elys directly binds the decondensing chromatin and interacts with the Nup107–160 subcomplex of NPCs, thus serving as a seeding point for the subsequent recruitment of other NPC subcomplexes and connecting chromatin with the re-forming NE. Recent studies also uncovered the important functions of Elys during interphase where it interacts with chromatin and affects its compactness. Therefore, Elys seems to be one of the key Nups regulating chromatin organization. This review summarizes the current state of our knowledge about the participation of Elys in the post-mitotic NPC reassembly as well as the role that Elys and other Nups play in the maintenance of genome architecture. MDPI 2020-12-13 /pmc/articles/PMC7764596/ /pubmed/33322130 http://dx.doi.org/10.3390/ijms21249475 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shevelyov, Yuri Y.
The Role of Nucleoporin Elys in Nuclear Pore Complex Assembly and Regulation of Genome Architecture
title The Role of Nucleoporin Elys in Nuclear Pore Complex Assembly and Regulation of Genome Architecture
title_full The Role of Nucleoporin Elys in Nuclear Pore Complex Assembly and Regulation of Genome Architecture
title_fullStr The Role of Nucleoporin Elys in Nuclear Pore Complex Assembly and Regulation of Genome Architecture
title_full_unstemmed The Role of Nucleoporin Elys in Nuclear Pore Complex Assembly and Regulation of Genome Architecture
title_short The Role of Nucleoporin Elys in Nuclear Pore Complex Assembly and Regulation of Genome Architecture
title_sort role of nucleoporin elys in nuclear pore complex assembly and regulation of genome architecture
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764596/
https://www.ncbi.nlm.nih.gov/pubmed/33322130
http://dx.doi.org/10.3390/ijms21249475
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