Alexander Disease Modeling in Zebrafish: An In Vivo System Suitable to Perform Drug Screening

Alexander disease (AxD) is a rare astrogliopathy caused by heterozygous mutations, either inherited or arising de novo, on the glial fibrillary acid protein (GFAP) gene (17q21). Mutations in the GFAP gene make the protein prone to forming aggregates which, together with heat-shock protein 27 (HSP27)...

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Detalles Bibliográficos
Autores principales: Candiani, Simona, Carestiato, Silvia, Mack, Andreas F., Bani, Daniele, Bozzo, Matteo, Obino, Valentina, Ori, Michela, Rosamilia, Francesca, De Sarlo, Miriam, Pestarino, Mario, Ceccherini, Isabella, Bachetti, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764705/
https://www.ncbi.nlm.nih.gov/pubmed/33322348
http://dx.doi.org/10.3390/genes11121490

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