Cargando…

Herpes Simplex Virus Type 1 Clinical Isolates Respond to UL29-Targeted siRNA Swarm Treatment Independent of Their Acyclovir Sensitivity

Acyclovir is the drug of choice for the treatment of herpes simplex virus (HSV) infections. Acyclovir-resistant HSV strains may emerge, especially during long-term drug use, and subsequently cause difficult-to-treat exacerbations. Previously, we set up a novel treatment approach, based on enzymatica...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kalke, Kiira, Lehtinen, Jenni, Gnjatovic, Jelena, Lund, Liisa M., Nyman, Marie C., Paavilainen, Henrik, Orpana, Julius, Lasanen, Tuomas, Frejborg, Fanny, Levanova, Alesia A., Vuorinen, Tytti, Poranen, Minna M., Hukkanen, Veijo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764767/ https://www.ncbi.nlm.nih.gov/pubmed/33322225 http://dx.doi.org/10.3390/v12121434

Ejemplares similares

The In Vitro Replication, Spread, and Oncolytic Potential of Finnish Circulating Strains of Herpes Simplex Virus Type 1
por: Kalke, Kiira, et al.
Publicado: (2022)

Swarms of chemically modified antiviral siRNA targeting herpes simplex virus infection in human corneal epithelial cells
por: Kalke, Kiira, et al.
Publicado: (2022)

Enzymatically synthesized 2′-fluoro-modified Dicer-substrate siRNA swarms against herpes simplex virus demonstrate enhanced antiviral efficacy and low cytotoxicity
por: Levanova, Alesia A., et al.
Publicado: (2020)

Attenuated Replication-Competent Herpes Simplex Virus Expressing an ECM-Modifying Transgene Hyaluronan Synthase 2 of Naked Mole Rat in Oncolytic Gene Therapy
por: Palomäki, Jussi, et al.
Publicado: (2023)

Native RNA Purification Method for Small RNA Molecules Based on Asymmetrical Flow Field-Flow Fractionation
por: Levanova, Alesia A., et al.
Publicado: (2022)

Enzymatically Produced Pools of Canonical and Dicer-Substrate siRNA Molecules Display Comparable Gene Silencing and Antiviral Activities against Herpes Simplex Virus
por: Romanovskaya, Alesia, et al.
Publicado: (2012)

Comparison of Herpes Simplex Virus 1 Strains Circulating in Finland Demonstrates the Uncoupling of Whole-Genome Relatedness and Phenotypic Outcomes of Viral Infection
por: Bowen, Christopher D., et al.
Publicado: (2019)

Herpes Simplex Virus Seroprevalence among Pregnant Finnish Women and Their Spouses—A Six-Year Follow-Up Cohort Study
por: Laakso, Johanna, et al.
Publicado: (2022)

RNA Interference as a Prospective Tool for the Control of Human Viral Infections
por: Levanova, Alesia, et al.
Publicado: (2018)

Herpes Simplex Virus Type 1 Us3 Gene Deletion Influences Toll-like Receptor Responses in Cultured Monocytic Cells
por: Peri, Piritta, et al.
Publicado: (2008)

RNA-Dependent RNA Polymerase from Heterobasidion RNA Virus 6 Is an Active Replicase In Vitro
por: Levanova, Alesia A., et al.
Publicado: (2021)

A Herpes Simplex Virus-Derived Replicative Vector Expressing LIF Limits Experimental Demyelinating Disease and Modulates Autoimmunity
por: Nygårdas, Michaela, et al.
Publicado: (2013)

Rhinovirus-induced first wheezing episode predicts atopic but not nonatopic asthma at school age
por: Lukkarinen, Minna, et al.
Publicado: (2017)

Prednisolone reduces recurrent wheezing after a first wheezing episode associated with rhinovirus infection or eczema
por: Lehtinen, Pasi, et al.
Publicado: (2007)

Herpesvirus Vectors in Gene Therapy
por: Hukkanen, Veijo
Publicado: (2010)

Systemic T-helper and T-regulatory cell type cytokine responses in rhinovirus vs. respiratory syncytial virus induced early wheezing: an observational study
por: Jartti, Tuomas, et al.
Publicado: (2009)

HERQ-9 Is a New Multiplex PCR for Differentiation and Quantification of All Nine Human Herpesviruses
por: Pyöriä, Lari, et al.
Publicado: (2020)

Short- and long-term efficacy of prednisolone for first acute rhinovirus-induced wheezing episode
por: Jartti, Tuomas, et al.
Publicado: (2015)

The combined effects of irradiation and herpes simplex virus type 1 infection on an immortal gingival cell line
por: Turunen, Aaro, et al.
Publicado: (2014)

Respiratory Picornaviruses and Respiratory Syncytial Virus as Causative Agents of Acute Expiratory Wheezing in Children
por: Jartti, Tuomas, et al.
Publicado: (2004)

Electrospun Structural Hybrids of Acyclovir-Polyacrylonitrile at Acyclovir for Modifying Drug Release
por: Lv, He, et al.
Publicado: (2021)

The UL15 protein of herpes simplex virus type 1 is necessary for the localization of the UL28 and UL33 proteins to viral DNA replication centres
por: Higgs, Martin R., et al.
Publicado: (2008)

Alopecia Following Oral Acyclovir for the Treatment of Herpes Simplex Keratitis
por: Sharma, Ashok, et al.
Publicado: (2014)

Neonatal Herpes Simplex Fulminant Hepatitis Successfully Treated with Acyclovir
por: Abuhasna, Said D., et al.
Publicado: (2012)

Necrotizing Keratitis Caused by Acyclovir-Resistant Herpes Simplex Virus
por: Toriyama, Koji, et al.
Publicado: (2014)

Treatment of acyclovir-resistant herpes simplex virus with intralesional cidofovir
por: Enescu, Christina D., et al.
Publicado: (2021)

Burden of influenza during the first year of life
por: Mattila, Janna‐Maija, et al.
Publicado: (2020)

Human lactoferrin but not lysozyme neutralizes HSV-1 and inhibits HSV-1 replication and cell-to-cell spread
por: Välimaa, Hannamari, et al.
Publicado: (2009)

Prevalence of Intrathecal Acyclovir Resistant Virus in Herpes Simplex Encephalitis Patients
por: Mitterreiter, Johanna G., et al.
Publicado: (2016)

Herpes Simplex Encephalitis Complicated by Cerebral Hemorrhage during Acyclovir Therapy
por: Harada, Yukinori, et al.
Publicado: (2017)

Acyclovir Therapy for Herpesvirus Infections
por: Baltimore, Robert S.
Publicado: (1990)

Acyclovir-induced thrombotic microangiopathy
por: Goli, R., et al.
Publicado: (2017)

Acyclovir Neurotoxicity in a Peritoneal Dialysis Patient: Report of a Case and Review of the Pharmacokinetics of Acyclovir
por: Sadjadi, Seyed-Ali, et al.
Publicado: (2018)

Dual Function of the pUL7-pUL51 Tegument Protein Complex in Herpes Simplex Virus 1 Infection
por: Albecka, Anna, et al.
Publicado: (2017)

Antisense RNA directed to the human papillomavirus type 16 E7 mRNA from herpes simplex virus type 1 derived vectors is expressed in CaSki cells and downregulates E7 mRNA
por: Kari, Ilkka, et al.
Publicado: (2007)

Thrombocytopenia Secondary to Herpes Simplex Virus-2 Infection Successfully Treated by Acyclovir
por: Siddiqui, Raheel S, et al.
Publicado: (2020)

Hypertrophic herpes simplex virus 2 infection resistant to acyclovir in an immunosuppressed patient
por: Tan, Charlie, et al.
Publicado: (2023)

Acyclovir Nephrotoxicity: A Case Report Highlighting the Importance of Prevention, Detection, and Treatment of Acyclovir-Induced Nephropathy
por: Fleischer, Raymond, et al.
Publicado: (2010)

Tricyclic Derivative of Acyclovir and Its Esters in Relation to the Esters of Acyclovir Enzymatic Stability: Enzymatic Stability Study
por: Muszalska-Kolos, Izabela, et al.
Publicado: (2020)

Low serum 25-hydroxyvitamin D levels are associated with increased risk of viral coinfections in wheezing children
por: Jartti, Tuomas, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_thuv641e328g5dujd7qpa7c7fk