Cargando…

Antioxidant Properties of Second-Generation Antipsychotics: Focus on Microglia

Recent studies suggest a primary role of oxidative stress in an early phase of the pathogenesis of schizophrenia and a strong neurobiological link has been found between dopaminergic system dysfunction, microglia overactivation, and oxidative stress. Different risk factors for schizophrenia increase...

Descripción completa

Detalles Bibliográficos
Autores principales:	Caruso, Giuseppe, Grasso, Margherita, Fidilio, Annamaria, Tascedda, Fabio, Drago, Filippo, Caraci, Filippo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764768/ https://www.ncbi.nlm.nih.gov/pubmed/33322693 http://dx.doi.org/10.3390/ph13120457

Ejemplares similares

Antioxidant Activity of Fluoxetine and Vortioxetine in a Non-Transgenic Animal Model of Alzheimer’s Disease
por: Caruso, Giuseppe, et al.
Publicado: (2021)

Prenatal stress induces a depressive-like phenotype in adolescent rats: The key role of TGF-β1 pathway
por: Fidilio, Annamaria, et al.
Publicado: (2022)

Fluoxetine and Vortioxetine Reverse Depressive-Like Phenotype and Memory Deficits Induced by Aβ(1-42) Oligomers in Mice: A Key Role of Transforming Growth Factor-β1
por: Torrisi, Sebastiano Alfio, et al.
Publicado: (2019)

Carnosine Decreases PMA-Induced Oxidative Stress and Inflammation in Murine Macrophages
por: Caruso, Giuseppe, et al.
Publicado: (2019)

Microfluidics as a Novel Tool for Biological and Toxicological Assays in Drug Discovery Processes: Focus on Microchip Electrophoresis
por: Caruso, Giuseppe, et al.
Publicado: (2020)

New antipsychotic drugs for the treatment of agitation and psychosis in Alzheimer’s disease: focus on brexpiprazole and pimavanserin
por: Caraci, Filippo, et al.
Publicado: (2020)

Rescue of Noradrenergic System as a Novel Pharmacological Strategy in the Treatment of Chronic Pain: Focus on Microglia Activation
por: Caraci, Filippo, et al.
Publicado: (2019)

Carnosine Protects Macrophages against the Toxicity of Aβ1-42 Oligomers by Decreasing Oxidative Stress
por: Caruso, Giuseppe, et al.
Publicado: (2021)

Dihydrotanshinone, a Natural Diterpenoid, Preserves Blood-Retinal Barrier Integrity via P2X7 Receptor
por: Fresta, Claudia Giuseppina, et al.
Publicado: (2020)

Carnosine Counteracts the Molecular Alterations Aβ Oligomers-Induced in Human Retinal Pigment Epithelial Cells
por: Caruso, Giuseppe, et al.
Publicado: (2023)

Microfluidic/HPLC combination to study carnosine protective activity on challenged human microglia: Focus on oxidative stress and energy metabolism
por: Privitera, Anna, et al.
Publicado: (2023)

A New Human Blood–Retinal Barrier Model Based on Endothelial Cells, Pericytes, and Astrocytes
por: Fresta, Claudia G., et al.
Publicado: (2020)

The Many Faces of Mitochondrial Dysfunction in Depression: From Pathology to Treatment
por: Caruso, Giuseppe, et al.
Publicado: (2019)

Antidepressant Drugs and Physical Activity: A Possible Synergism in the Treatment of Major Depression?
por: Guerrera, Claudia Savia, et al.
Publicado: (2020)

Gap Junctions and Connexins in Microglia-Related Oxidative Stress and Neuroinflammation: Perspectives for Drug Discovery
por: Caruso, Giuseppe, et al.
Publicado: (2023)

Modulation of Pro-Oxidant and Pro-Inflammatory Activities of M1 Macrophages by the Natural Dipeptide Carnosine
por: Fresta, Claudia G., et al.
Publicado: (2020)

The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling
por: Fidilio, Annamaria, et al.
Publicado: (2021)

New drugs in psychiatry: focus on new pharmacological targets
por: Caraci, Filippo, et al.
Publicado: (2017)

The therapeutic potential of carnosine: Focus on cellular and molecular mechanisms
por: Caruso, Giuseppe, et al.
Publicado: (2023)

Topical Ocular Delivery of TGF-β1 to the Back of the Eye: Implications in Age-Related Neurodegenerative Diseases
por: Platania, Chiara Bianca Maria, et al.
Publicado: (2017)

Dopamine, Cognitive Impairments and Second-Generation Antipsychotics: From Mechanistic Advances to More Personalized Treatments
por: Torrisi, Sebastiano Alfio, et al.
Publicado: (2020)

Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1
por: Caruso, Giuseppe, et al.
Publicado: (2019)

The dynamic interaction between symptoms and pharmacological treatment in patients with major depressive disorder: the role of network intervention analysis
por: Guerrera, Claudia Savia, et al.
Publicado: (2023)

Different Modulatory Effects of Four Methicillin-Resistant Staphylococcus aureus Clones on MG-63 Osteoblast-Like Cells
por: Musso, Nicolò, et al.
Publicado: (2021)

The Therapeutic Potential of Novel Carnosine Formulations: Perspectives for Drug Development
por: Bonaccorso, Angela, et al.
Publicado: (2023)

Bioequivalence, Drugs with Narrow Therapeutic Index and the Phenomenon of Biocreep: A Critical Analysis of the System for Generic Substitution
por: Gozzo, Lucia, et al.
Publicado: (2022)

Improving Cognition with Nutraceuticals Targeting TGF-β1 Signaling
por: Grasso, Margherita, et al.
Publicado: (2021)

Fluoxetine Prevents Aβ(1-42)-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth-Factor-β1
por: Caraci, Filippo, et al.
Publicado: (2016)

Omega-3 Fatty Acids and Depression: Scientific Evidence and Biological Mechanisms
por: Grosso, Giuseppe, et al.
Publicado: (2014)

Due to their anti-inflammatory, antioxidant and neurotrophic properties, second-generation antipsychotics are suitable in patients with schizophrenia and COVID-19
por: Tendilla-Beltrán, Hiram, et al.
Publicado: (2021)

The Role of Dopamine D3 Receptors, Dysbindin, and Their Functional Interaction in the Expression of Key Genes for Neuroplasticity and Neuroinflammation in the Mouse Brain
por: Rivi, Veronica, et al.
Publicado: (2023)

The Therapeutic Potential of Carnosine as an Antidote against Drug-Induced Cardiotoxicity and Neurotoxicity: Focus on Nrf2 Pathway
por: Caruso, Giuseppe, et al.
Publicado: (2022)

Characterization of Carnosine Effect on Human Microglial Cells under Basal Conditions
por: Caruso, Giuseppe, et al.
Publicado: (2023)

Neuroprotective Effect of Carnosine Is Mediated by Insulin-Degrading Enzyme
por: Distefano, Alessia, et al.
Publicado: (2022)

Role of Omega-3 Fatty Acids in the Treatment of Depressive Disorders: A Comprehensive Meta-Analysis of Randomized Clinical Trials
por: Grosso, Giuseppe, et al.
Publicado: (2014)

Second-Generation Antipsychotics and Extrapyramidal Adverse Effects
por: Divac, Nevena, et al.
Publicado: (2014)

Arterial Stiffness in Patients Taking Second-generation Antipsychotics
por: Fındıklı, Ebru, et al.
Publicado: (2016)

Effects of Novel Nitric Oxide-Releasing Molecules against Oxidative Stress on Retinal Pigmented Epithelial Cells
por: Pittalà, Valeria, et al.
Publicado: (2017)

First-generation vs second-generation antipsychotic drugs: The ongoing saga
por: Gupta, Sumeet
Publicado: (2010)

Predictors of functional outcome in patients with major depression and bipolar disorder: A dynamic network approach to identify distinct patterns of interacting symptoms
por: Platania, Giuseppe Alessio, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_o80hptom2oqp1h9fpiipa9jonf