Cargando…
Anti-Inflammatory Effects of Asian Fawn Lily (Erythronium japonicum) Extract on Lipopolysaccharide-Induced Depressive-Like Behavior in Mice
Neuroinflammation is associated with an increased risk of depression. Lipopolysaccharide (LPS) treatment is known to induce pro-inflammatory cytokine secretion and a depressive-like phenotype in mice. Although Erythronium japonicum exhibits various health benefits, the role of E. japonicum extract (...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764803/ https://www.ncbi.nlm.nih.gov/pubmed/33322645 http://dx.doi.org/10.3390/nu12123809 |
_version_ | 1783628343643471872 |
---|---|
author | Lim, Dong Wook Park, Joon Han, Daeseok Lee, Jaekwang Kim, Yun Tai Lee, Changho |
author_facet | Lim, Dong Wook Park, Joon Han, Daeseok Lee, Jaekwang Kim, Yun Tai Lee, Changho |
author_sort | Lim, Dong Wook |
collection | PubMed |
description | Neuroinflammation is associated with an increased risk of depression. Lipopolysaccharide (LPS) treatment is known to induce pro-inflammatory cytokine secretion and a depressive-like phenotype in mice. Although Erythronium japonicum exhibits various health benefits, the role of E. japonicum extract (EJE) in inflammation-associated depression is unknown. This study aimed to explore the anti-inflammatory effect of EJE on LPS-induced depressive symptoms in mice using the open field test (OFT), passive avoidance test (PAT), tail suspension test (TST), and forced swim test (FST). LPS-treated mice had significantly increased immobility time in the TST and FST, decreased step-through latency time in the PAT, and decreased locomotor activity in the OFT. However, administration of 100 and 300 mg/kg of EJE significantly improved these depressive-like behaviors. EJE also prevented the increase in mRNA levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, and monocyte chemoattractant protein-1 (MCP-1), and the decrease in IL-10 levels by inhibiting nuclear factor-κB (NF-κB) subunit p65 phosphorylation. Additionally, LPS-treated mice showed markedly decreased brain-derived neurotrophic factor (BDNF) levels and phosphorylation of phosphoinositide 3-kinase (PI3K) and Akt, while EJE treatment significantly increased these levels in the hippocampus. These results suggest that EJE ameliorated LPS-induced depressive-like behavior by reducing LPS-induced neuroinflammation and activating the BDNF-PI3K/Akt pathway. |
format | Online Article Text |
id | pubmed-7764803 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77648032020-12-27 Anti-Inflammatory Effects of Asian Fawn Lily (Erythronium japonicum) Extract on Lipopolysaccharide-Induced Depressive-Like Behavior in Mice Lim, Dong Wook Park, Joon Han, Daeseok Lee, Jaekwang Kim, Yun Tai Lee, Changho Nutrients Article Neuroinflammation is associated with an increased risk of depression. Lipopolysaccharide (LPS) treatment is known to induce pro-inflammatory cytokine secretion and a depressive-like phenotype in mice. Although Erythronium japonicum exhibits various health benefits, the role of E. japonicum extract (EJE) in inflammation-associated depression is unknown. This study aimed to explore the anti-inflammatory effect of EJE on LPS-induced depressive symptoms in mice using the open field test (OFT), passive avoidance test (PAT), tail suspension test (TST), and forced swim test (FST). LPS-treated mice had significantly increased immobility time in the TST and FST, decreased step-through latency time in the PAT, and decreased locomotor activity in the OFT. However, administration of 100 and 300 mg/kg of EJE significantly improved these depressive-like behaviors. EJE also prevented the increase in mRNA levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, and monocyte chemoattractant protein-1 (MCP-1), and the decrease in IL-10 levels by inhibiting nuclear factor-κB (NF-κB) subunit p65 phosphorylation. Additionally, LPS-treated mice showed markedly decreased brain-derived neurotrophic factor (BDNF) levels and phosphorylation of phosphoinositide 3-kinase (PI3K) and Akt, while EJE treatment significantly increased these levels in the hippocampus. These results suggest that EJE ameliorated LPS-induced depressive-like behavior by reducing LPS-induced neuroinflammation and activating the BDNF-PI3K/Akt pathway. MDPI 2020-12-11 /pmc/articles/PMC7764803/ /pubmed/33322645 http://dx.doi.org/10.3390/nu12123809 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lim, Dong Wook Park, Joon Han, Daeseok Lee, Jaekwang Kim, Yun Tai Lee, Changho Anti-Inflammatory Effects of Asian Fawn Lily (Erythronium japonicum) Extract on Lipopolysaccharide-Induced Depressive-Like Behavior in Mice |
title | Anti-Inflammatory Effects of Asian Fawn Lily (Erythronium japonicum) Extract on Lipopolysaccharide-Induced Depressive-Like Behavior in Mice |
title_full | Anti-Inflammatory Effects of Asian Fawn Lily (Erythronium japonicum) Extract on Lipopolysaccharide-Induced Depressive-Like Behavior in Mice |
title_fullStr | Anti-Inflammatory Effects of Asian Fawn Lily (Erythronium japonicum) Extract on Lipopolysaccharide-Induced Depressive-Like Behavior in Mice |
title_full_unstemmed | Anti-Inflammatory Effects of Asian Fawn Lily (Erythronium japonicum) Extract on Lipopolysaccharide-Induced Depressive-Like Behavior in Mice |
title_short | Anti-Inflammatory Effects of Asian Fawn Lily (Erythronium japonicum) Extract on Lipopolysaccharide-Induced Depressive-Like Behavior in Mice |
title_sort | anti-inflammatory effects of asian fawn lily (erythronium japonicum) extract on lipopolysaccharide-induced depressive-like behavior in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764803/ https://www.ncbi.nlm.nih.gov/pubmed/33322645 http://dx.doi.org/10.3390/nu12123809 |
work_keys_str_mv | AT limdongwook antiinflammatoryeffectsofasianfawnlilyerythroniumjaponicumextractonlipopolysaccharideinduceddepressivelikebehaviorinmice AT parkjoon antiinflammatoryeffectsofasianfawnlilyerythroniumjaponicumextractonlipopolysaccharideinduceddepressivelikebehaviorinmice AT handaeseok antiinflammatoryeffectsofasianfawnlilyerythroniumjaponicumextractonlipopolysaccharideinduceddepressivelikebehaviorinmice AT leejaekwang antiinflammatoryeffectsofasianfawnlilyerythroniumjaponicumextractonlipopolysaccharideinduceddepressivelikebehaviorinmice AT kimyuntai antiinflammatoryeffectsofasianfawnlilyerythroniumjaponicumextractonlipopolysaccharideinduceddepressivelikebehaviorinmice AT leechangho antiinflammatoryeffectsofasianfawnlilyerythroniumjaponicumextractonlipopolysaccharideinduceddepressivelikebehaviorinmice |