Cargando…
Multifunctional Properties of Binary Polyrhodanine Manganese Ferrite Nanohybrids—From the Energy Converters to Biological Activity
The PRHD@MnFe(2)O(4) binary hybrids have shown a potential for applications in the biomedical field. The polymer cover/shell provides sufficient surface protection of magnetic nanoparticles against adverse effects on the biological systems, e.g., it protects against Fenton’s reactions and the genera...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764815/ https://www.ncbi.nlm.nih.gov/pubmed/33302596 http://dx.doi.org/10.3390/polym12122934 |
_version_ | 1783628346445266944 |
---|---|
author | Zachanowicz, Emilia Kulpa-Greszta, Magdalena Tomaszewska, Anna Gazińska, Małgorzata Marędziak, Monika Marycz, Krzysztof Pązik, Robert |
author_facet | Zachanowicz, Emilia Kulpa-Greszta, Magdalena Tomaszewska, Anna Gazińska, Małgorzata Marędziak, Monika Marycz, Krzysztof Pązik, Robert |
author_sort | Zachanowicz, Emilia |
collection | PubMed |
description | The PRHD@MnFe(2)O(4) binary hybrids have shown a potential for applications in the biomedical field. The polymer cover/shell provides sufficient surface protection of magnetic nanoparticles against adverse effects on the biological systems, e.g., it protects against Fenton’s reactions and the generation of highly toxic radicals. The heating ability of the PRHD@MnFe(2)O(4) was measured as a laser optical density (LOD) dependence either for powders as well as nanohybrid dispersions. Dry hybrids exposed to the action of NIR radiation (808 nm) can effectively convert energy into heat that led to the enormous temperature increase ΔT 170 °C (>190 °C). High concentrated colloidal suspensions (5 mg/mL) can generate ΔT of 42 °C (65 °C). Further optimization of the nanohybrids amount and laser parameters provides the possibility of temperature control within a biologically relevant range. Biological interactions of PRHD@MnFe(2)O(4) hybrids were tested using three specific cell lines: macrophages (RAW 264.7), osteosarcoma cells line (UMR-106), and stromal progenitor cells of adipose tissue (ASCs). It was shown that the cell response was strongly dependent on hybrid concentration. Antimicrobial activity of the proposed composites against Escherichia coli and Staphylococcus aureus was confirmed, showing potential in the exploitation of the fabricated materials in this field. |
format | Online Article Text |
id | pubmed-7764815 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77648152020-12-27 Multifunctional Properties of Binary Polyrhodanine Manganese Ferrite Nanohybrids—From the Energy Converters to Biological Activity Zachanowicz, Emilia Kulpa-Greszta, Magdalena Tomaszewska, Anna Gazińska, Małgorzata Marędziak, Monika Marycz, Krzysztof Pązik, Robert Polymers (Basel) Article The PRHD@MnFe(2)O(4) binary hybrids have shown a potential for applications in the biomedical field. The polymer cover/shell provides sufficient surface protection of magnetic nanoparticles against adverse effects on the biological systems, e.g., it protects against Fenton’s reactions and the generation of highly toxic radicals. The heating ability of the PRHD@MnFe(2)O(4) was measured as a laser optical density (LOD) dependence either for powders as well as nanohybrid dispersions. Dry hybrids exposed to the action of NIR radiation (808 nm) can effectively convert energy into heat that led to the enormous temperature increase ΔT 170 °C (>190 °C). High concentrated colloidal suspensions (5 mg/mL) can generate ΔT of 42 °C (65 °C). Further optimization of the nanohybrids amount and laser parameters provides the possibility of temperature control within a biologically relevant range. Biological interactions of PRHD@MnFe(2)O(4) hybrids were tested using three specific cell lines: macrophages (RAW 264.7), osteosarcoma cells line (UMR-106), and stromal progenitor cells of adipose tissue (ASCs). It was shown that the cell response was strongly dependent on hybrid concentration. Antimicrobial activity of the proposed composites against Escherichia coli and Staphylococcus aureus was confirmed, showing potential in the exploitation of the fabricated materials in this field. MDPI 2020-12-08 /pmc/articles/PMC7764815/ /pubmed/33302596 http://dx.doi.org/10.3390/polym12122934 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zachanowicz, Emilia Kulpa-Greszta, Magdalena Tomaszewska, Anna Gazińska, Małgorzata Marędziak, Monika Marycz, Krzysztof Pązik, Robert Multifunctional Properties of Binary Polyrhodanine Manganese Ferrite Nanohybrids—From the Energy Converters to Biological Activity |
title | Multifunctional Properties of Binary Polyrhodanine Manganese Ferrite Nanohybrids—From the Energy Converters to Biological Activity |
title_full | Multifunctional Properties of Binary Polyrhodanine Manganese Ferrite Nanohybrids—From the Energy Converters to Biological Activity |
title_fullStr | Multifunctional Properties of Binary Polyrhodanine Manganese Ferrite Nanohybrids—From the Energy Converters to Biological Activity |
title_full_unstemmed | Multifunctional Properties of Binary Polyrhodanine Manganese Ferrite Nanohybrids—From the Energy Converters to Biological Activity |
title_short | Multifunctional Properties of Binary Polyrhodanine Manganese Ferrite Nanohybrids—From the Energy Converters to Biological Activity |
title_sort | multifunctional properties of binary polyrhodanine manganese ferrite nanohybrids—from the energy converters to biological activity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764815/ https://www.ncbi.nlm.nih.gov/pubmed/33302596 http://dx.doi.org/10.3390/polym12122934 |
work_keys_str_mv | AT zachanowiczemilia multifunctionalpropertiesofbinarypolyrhodaninemanganeseferritenanohybridsfromtheenergyconverterstobiologicalactivity AT kulpagresztamagdalena multifunctionalpropertiesofbinarypolyrhodaninemanganeseferritenanohybridsfromtheenergyconverterstobiologicalactivity AT tomaszewskaanna multifunctionalpropertiesofbinarypolyrhodaninemanganeseferritenanohybridsfromtheenergyconverterstobiologicalactivity AT gazinskamałgorzata multifunctionalpropertiesofbinarypolyrhodaninemanganeseferritenanohybridsfromtheenergyconverterstobiologicalactivity AT maredziakmonika multifunctionalpropertiesofbinarypolyrhodaninemanganeseferritenanohybridsfromtheenergyconverterstobiologicalactivity AT maryczkrzysztof multifunctionalpropertiesofbinarypolyrhodaninemanganeseferritenanohybridsfromtheenergyconverterstobiologicalactivity AT pazikrobert multifunctionalpropertiesofbinarypolyrhodaninemanganeseferritenanohybridsfromtheenergyconverterstobiologicalactivity |