Cargando…

Multifunctional Properties of Binary Polyrhodanine Manganese Ferrite Nanohybrids—From the Energy Converters to Biological Activity

The PRHD@MnFe(2)O(4) binary hybrids have shown a potential for applications in the biomedical field. The polymer cover/shell provides sufficient surface protection of magnetic nanoparticles against adverse effects on the biological systems, e.g., it protects against Fenton’s reactions and the genera...

Descripción completa

Detalles Bibliográficos
Autores principales: Zachanowicz, Emilia, Kulpa-Greszta, Magdalena, Tomaszewska, Anna, Gazińska, Małgorzata, Marędziak, Monika, Marycz, Krzysztof, Pązik, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764815/
https://www.ncbi.nlm.nih.gov/pubmed/33302596
http://dx.doi.org/10.3390/polym12122934
_version_ 1783628346445266944
author Zachanowicz, Emilia
Kulpa-Greszta, Magdalena
Tomaszewska, Anna
Gazińska, Małgorzata
Marędziak, Monika
Marycz, Krzysztof
Pązik, Robert
author_facet Zachanowicz, Emilia
Kulpa-Greszta, Magdalena
Tomaszewska, Anna
Gazińska, Małgorzata
Marędziak, Monika
Marycz, Krzysztof
Pązik, Robert
author_sort Zachanowicz, Emilia
collection PubMed
description The PRHD@MnFe(2)O(4) binary hybrids have shown a potential for applications in the biomedical field. The polymer cover/shell provides sufficient surface protection of magnetic nanoparticles against adverse effects on the biological systems, e.g., it protects against Fenton’s reactions and the generation of highly toxic radicals. The heating ability of the PRHD@MnFe(2)O(4) was measured as a laser optical density (LOD) dependence either for powders as well as nanohybrid dispersions. Dry hybrids exposed to the action of NIR radiation (808 nm) can effectively convert energy into heat that led to the enormous temperature increase ΔT 170 °C (>190 °C). High concentrated colloidal suspensions (5 mg/mL) can generate ΔT of 42 °C (65 °C). Further optimization of the nanohybrids amount and laser parameters provides the possibility of temperature control within a biologically relevant range. Biological interactions of PRHD@MnFe(2)O(4) hybrids were tested using three specific cell lines: macrophages (RAW 264.7), osteosarcoma cells line (UMR-106), and stromal progenitor cells of adipose tissue (ASCs). It was shown that the cell response was strongly dependent on hybrid concentration. Antimicrobial activity of the proposed composites against Escherichia coli and Staphylococcus aureus was confirmed, showing potential in the exploitation of the fabricated materials in this field.
format Online
Article
Text
id pubmed-7764815
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-77648152020-12-27 Multifunctional Properties of Binary Polyrhodanine Manganese Ferrite Nanohybrids—From the Energy Converters to Biological Activity Zachanowicz, Emilia Kulpa-Greszta, Magdalena Tomaszewska, Anna Gazińska, Małgorzata Marędziak, Monika Marycz, Krzysztof Pązik, Robert Polymers (Basel) Article The PRHD@MnFe(2)O(4) binary hybrids have shown a potential for applications in the biomedical field. The polymer cover/shell provides sufficient surface protection of magnetic nanoparticles against adverse effects on the biological systems, e.g., it protects against Fenton’s reactions and the generation of highly toxic radicals. The heating ability of the PRHD@MnFe(2)O(4) was measured as a laser optical density (LOD) dependence either for powders as well as nanohybrid dispersions. Dry hybrids exposed to the action of NIR radiation (808 nm) can effectively convert energy into heat that led to the enormous temperature increase ΔT 170 °C (>190 °C). High concentrated colloidal suspensions (5 mg/mL) can generate ΔT of 42 °C (65 °C). Further optimization of the nanohybrids amount and laser parameters provides the possibility of temperature control within a biologically relevant range. Biological interactions of PRHD@MnFe(2)O(4) hybrids were tested using three specific cell lines: macrophages (RAW 264.7), osteosarcoma cells line (UMR-106), and stromal progenitor cells of adipose tissue (ASCs). It was shown that the cell response was strongly dependent on hybrid concentration. Antimicrobial activity of the proposed composites against Escherichia coli and Staphylococcus aureus was confirmed, showing potential in the exploitation of the fabricated materials in this field. MDPI 2020-12-08 /pmc/articles/PMC7764815/ /pubmed/33302596 http://dx.doi.org/10.3390/polym12122934 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zachanowicz, Emilia
Kulpa-Greszta, Magdalena
Tomaszewska, Anna
Gazińska, Małgorzata
Marędziak, Monika
Marycz, Krzysztof
Pązik, Robert
Multifunctional Properties of Binary Polyrhodanine Manganese Ferrite Nanohybrids—From the Energy Converters to Biological Activity
title Multifunctional Properties of Binary Polyrhodanine Manganese Ferrite Nanohybrids—From the Energy Converters to Biological Activity
title_full Multifunctional Properties of Binary Polyrhodanine Manganese Ferrite Nanohybrids—From the Energy Converters to Biological Activity
title_fullStr Multifunctional Properties of Binary Polyrhodanine Manganese Ferrite Nanohybrids—From the Energy Converters to Biological Activity
title_full_unstemmed Multifunctional Properties of Binary Polyrhodanine Manganese Ferrite Nanohybrids—From the Energy Converters to Biological Activity
title_short Multifunctional Properties of Binary Polyrhodanine Manganese Ferrite Nanohybrids—From the Energy Converters to Biological Activity
title_sort multifunctional properties of binary polyrhodanine manganese ferrite nanohybrids—from the energy converters to biological activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764815/
https://www.ncbi.nlm.nih.gov/pubmed/33302596
http://dx.doi.org/10.3390/polym12122934
work_keys_str_mv AT zachanowiczemilia multifunctionalpropertiesofbinarypolyrhodaninemanganeseferritenanohybridsfromtheenergyconverterstobiologicalactivity
AT kulpagresztamagdalena multifunctionalpropertiesofbinarypolyrhodaninemanganeseferritenanohybridsfromtheenergyconverterstobiologicalactivity
AT tomaszewskaanna multifunctionalpropertiesofbinarypolyrhodaninemanganeseferritenanohybridsfromtheenergyconverterstobiologicalactivity
AT gazinskamałgorzata multifunctionalpropertiesofbinarypolyrhodaninemanganeseferritenanohybridsfromtheenergyconverterstobiologicalactivity
AT maredziakmonika multifunctionalpropertiesofbinarypolyrhodaninemanganeseferritenanohybridsfromtheenergyconverterstobiologicalactivity
AT maryczkrzysztof multifunctionalpropertiesofbinarypolyrhodaninemanganeseferritenanohybridsfromtheenergyconverterstobiologicalactivity
AT pazikrobert multifunctionalpropertiesofbinarypolyrhodaninemanganeseferritenanohybridsfromtheenergyconverterstobiologicalactivity