Cargando…
Does Botulinum Toxin Treatment Affect the Ultrasonographic Characteristics of Post-Stroke Spastic Equinus? A Retrospective Pilot Study
Equinovarus/equinus foot is a pattern most commonly treated with botulinum toxin type A in patients with post-stroke spasticity involving the lower limbs; the gastrocnemius is the muscle most frequently injected. Spastic equinovarus/equinus can present a mixture of conditions, including spasticity,...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764832/ https://www.ncbi.nlm.nih.gov/pubmed/33327423 http://dx.doi.org/10.3390/toxins12120797 |
_version_ | 1783628350534713344 |
---|---|
author | Picelli, Alessandro Filippetti, Mirko Melotti, Camilla Guerrazzi, Flavio Modenese, Angela Smania, Nicola |
author_facet | Picelli, Alessandro Filippetti, Mirko Melotti, Camilla Guerrazzi, Flavio Modenese, Angela Smania, Nicola |
author_sort | Picelli, Alessandro |
collection | PubMed |
description | Equinovarus/equinus foot is a pattern most commonly treated with botulinum toxin type A in patients with post-stroke spasticity involving the lower limbs; the gastrocnemius is the muscle most frequently injected. Spastic equinovarus/equinus can present a mixture of conditions, including spasticity, muscle/tendon shortening, muscle weakness and imbalance. In this study, we wanted to determine whether botulinum toxin treatment affects the ultrasonographic characteristics of post-stroke spastic equinus. The same dose of AbobotulinumtoxinA was injected into the gastrocnemius medialis and lateralis of 21 chronic stroke patients with spastic equinus. Clinical (Ashworth scale and ankle range of motion) and ultrasound (conventional and sonoelastography) evaluation of the treated leg was carried out before and 4 weeks after injection. No significant effects of botulinum toxin treatment on the ultrasonographic characteristics of spastic equinus were observed. As expected, there were significant improvements in ankle passive dorsiflexion range of motion and calf muscle spasticity at 1 month after treatment. There was a direct association between Achilles tendon elasticity and calf muscle spasticity at baseline evaluation. Larger studies with a long-term timeline of serial evaluations are needed to further investigate the possible effects of botulinum toxin injection on spastic muscle characteristics in patients with post-stroke spasticity. |
format | Online Article Text |
id | pubmed-7764832 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77648322020-12-27 Does Botulinum Toxin Treatment Affect the Ultrasonographic Characteristics of Post-Stroke Spastic Equinus? A Retrospective Pilot Study Picelli, Alessandro Filippetti, Mirko Melotti, Camilla Guerrazzi, Flavio Modenese, Angela Smania, Nicola Toxins (Basel) Communication Equinovarus/equinus foot is a pattern most commonly treated with botulinum toxin type A in patients with post-stroke spasticity involving the lower limbs; the gastrocnemius is the muscle most frequently injected. Spastic equinovarus/equinus can present a mixture of conditions, including spasticity, muscle/tendon shortening, muscle weakness and imbalance. In this study, we wanted to determine whether botulinum toxin treatment affects the ultrasonographic characteristics of post-stroke spastic equinus. The same dose of AbobotulinumtoxinA was injected into the gastrocnemius medialis and lateralis of 21 chronic stroke patients with spastic equinus. Clinical (Ashworth scale and ankle range of motion) and ultrasound (conventional and sonoelastography) evaluation of the treated leg was carried out before and 4 weeks after injection. No significant effects of botulinum toxin treatment on the ultrasonographic characteristics of spastic equinus were observed. As expected, there were significant improvements in ankle passive dorsiflexion range of motion and calf muscle spasticity at 1 month after treatment. There was a direct association between Achilles tendon elasticity and calf muscle spasticity at baseline evaluation. Larger studies with a long-term timeline of serial evaluations are needed to further investigate the possible effects of botulinum toxin injection on spastic muscle characteristics in patients with post-stroke spasticity. MDPI 2020-12-14 /pmc/articles/PMC7764832/ /pubmed/33327423 http://dx.doi.org/10.3390/toxins12120797 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Picelli, Alessandro Filippetti, Mirko Melotti, Camilla Guerrazzi, Flavio Modenese, Angela Smania, Nicola Does Botulinum Toxin Treatment Affect the Ultrasonographic Characteristics of Post-Stroke Spastic Equinus? A Retrospective Pilot Study |
title | Does Botulinum Toxin Treatment Affect the Ultrasonographic Characteristics of Post-Stroke Spastic Equinus? A Retrospective Pilot Study |
title_full | Does Botulinum Toxin Treatment Affect the Ultrasonographic Characteristics of Post-Stroke Spastic Equinus? A Retrospective Pilot Study |
title_fullStr | Does Botulinum Toxin Treatment Affect the Ultrasonographic Characteristics of Post-Stroke Spastic Equinus? A Retrospective Pilot Study |
title_full_unstemmed | Does Botulinum Toxin Treatment Affect the Ultrasonographic Characteristics of Post-Stroke Spastic Equinus? A Retrospective Pilot Study |
title_short | Does Botulinum Toxin Treatment Affect the Ultrasonographic Characteristics of Post-Stroke Spastic Equinus? A Retrospective Pilot Study |
title_sort | does botulinum toxin treatment affect the ultrasonographic characteristics of post-stroke spastic equinus? a retrospective pilot study |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764832/ https://www.ncbi.nlm.nih.gov/pubmed/33327423 http://dx.doi.org/10.3390/toxins12120797 |
work_keys_str_mv | AT picellialessandro doesbotulinumtoxintreatmentaffecttheultrasonographiccharacteristicsofpoststrokespasticequinusaretrospectivepilotstudy AT filippettimirko doesbotulinumtoxintreatmentaffecttheultrasonographiccharacteristicsofpoststrokespasticequinusaretrospectivepilotstudy AT melotticamilla doesbotulinumtoxintreatmentaffecttheultrasonographiccharacteristicsofpoststrokespasticequinusaretrospectivepilotstudy AT guerrazziflavio doesbotulinumtoxintreatmentaffecttheultrasonographiccharacteristicsofpoststrokespasticequinusaretrospectivepilotstudy AT modeneseangela doesbotulinumtoxintreatmentaffecttheultrasonographiccharacteristicsofpoststrokespasticequinusaretrospectivepilotstudy AT smanianicola doesbotulinumtoxintreatmentaffecttheultrasonographiccharacteristicsofpoststrokespasticequinusaretrospectivepilotstudy |