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Modified Bacterial Cellulose Dressings to Treat Inflammatory Wounds
Natural products suited for prophylaxis and therapy of inflammatory diseases have gained increasing importance. These compounds could be beneficially integrated into bacterial cellulose (BC), which is a natural hydropolymer applicable as a wound dressing and drug delivery system alike. This study pr...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764978/ https://www.ncbi.nlm.nih.gov/pubmed/33327519 http://dx.doi.org/10.3390/nano10122508 |
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author | Beekmann, Uwe Zahel, Paul Karl, Berit Schmölz, Lisa Börner, Friedemann Gerstmeier, Jana Werz, Oliver Lorkowski, Stefan Wiegand, Cornelia Fischer, Dagmar Kralisch, Dana |
author_facet | Beekmann, Uwe Zahel, Paul Karl, Berit Schmölz, Lisa Börner, Friedemann Gerstmeier, Jana Werz, Oliver Lorkowski, Stefan Wiegand, Cornelia Fischer, Dagmar Kralisch, Dana |
author_sort | Beekmann, Uwe |
collection | PubMed |
description | Natural products suited for prophylaxis and therapy of inflammatory diseases have gained increasing importance. These compounds could be beneficially integrated into bacterial cellulose (BC), which is a natural hydropolymer applicable as a wound dressing and drug delivery system alike. This study presents experimental outcomes for a natural anti-inflammatory product concept of boswellic acids from frankincense formulated in BC. Using esterification respectively (resp.) oxidation and subsequent coupling with phenylalanine and tryptophan, post-modification of BC was tested to facilitate lipophilic active pharmaceutical ingredient (API) incorporation. Diclofenac sodium and indomethacin were used as anti-inflammatory model drugs before the findings were transferred to boswellic acids. By acetylation of BC fibers, the loading efficiency for the more lipophilic API indomethacin and the release was increased by up to 65.6% and 25%, respectively, while no significant differences in loading could be found for the API diclofenac sodium. Post-modifications could be made while preserving biocompatibility, essential wound dressing properties and anti-inflammatory efficacy. Eventually, in vitro wound closure experiments and evaluations of the effect of secondary dressings completed the study. |
format | Online Article Text |
id | pubmed-7764978 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77649782020-12-27 Modified Bacterial Cellulose Dressings to Treat Inflammatory Wounds Beekmann, Uwe Zahel, Paul Karl, Berit Schmölz, Lisa Börner, Friedemann Gerstmeier, Jana Werz, Oliver Lorkowski, Stefan Wiegand, Cornelia Fischer, Dagmar Kralisch, Dana Nanomaterials (Basel) Article Natural products suited for prophylaxis and therapy of inflammatory diseases have gained increasing importance. These compounds could be beneficially integrated into bacterial cellulose (BC), which is a natural hydropolymer applicable as a wound dressing and drug delivery system alike. This study presents experimental outcomes for a natural anti-inflammatory product concept of boswellic acids from frankincense formulated in BC. Using esterification respectively (resp.) oxidation and subsequent coupling with phenylalanine and tryptophan, post-modification of BC was tested to facilitate lipophilic active pharmaceutical ingredient (API) incorporation. Diclofenac sodium and indomethacin were used as anti-inflammatory model drugs before the findings were transferred to boswellic acids. By acetylation of BC fibers, the loading efficiency for the more lipophilic API indomethacin and the release was increased by up to 65.6% and 25%, respectively, while no significant differences in loading could be found for the API diclofenac sodium. Post-modifications could be made while preserving biocompatibility, essential wound dressing properties and anti-inflammatory efficacy. Eventually, in vitro wound closure experiments and evaluations of the effect of secondary dressings completed the study. MDPI 2020-12-14 /pmc/articles/PMC7764978/ /pubmed/33327519 http://dx.doi.org/10.3390/nano10122508 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Beekmann, Uwe Zahel, Paul Karl, Berit Schmölz, Lisa Börner, Friedemann Gerstmeier, Jana Werz, Oliver Lorkowski, Stefan Wiegand, Cornelia Fischer, Dagmar Kralisch, Dana Modified Bacterial Cellulose Dressings to Treat Inflammatory Wounds |
title | Modified Bacterial Cellulose Dressings to Treat Inflammatory Wounds |
title_full | Modified Bacterial Cellulose Dressings to Treat Inflammatory Wounds |
title_fullStr | Modified Bacterial Cellulose Dressings to Treat Inflammatory Wounds |
title_full_unstemmed | Modified Bacterial Cellulose Dressings to Treat Inflammatory Wounds |
title_short | Modified Bacterial Cellulose Dressings to Treat Inflammatory Wounds |
title_sort | modified bacterial cellulose dressings to treat inflammatory wounds |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764978/ https://www.ncbi.nlm.nih.gov/pubmed/33327519 http://dx.doi.org/10.3390/nano10122508 |
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