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TXNIP Regulates Natural Killer Cell-Mediated Innate Immunity by Inhibiting IFN-γ Production during Bacterial Infection
The function of natural killer (NK) cell-derived interferon-γ (IFN-γ) expands to remove pathogens by increasing the ability of innate immune cells. Here, we identified the critical role of thioredoxin-interacting protein (TXNIP) in the production of IFN-γ in NK cells during bacterial infection. TXNI...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765025/ https://www.ncbi.nlm.nih.gov/pubmed/33327533 http://dx.doi.org/10.3390/ijms21249499 |
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author | Kim, Dong Oh Byun, Jae-Eun Kim, Won Sam Kim, Mi Jeong Choi, Jung Ha Kim, Hanna Choi, Eunji Kim, Tae-Don Yoon, Suk Ran Noh, Ji-Yoon Park, Young-Jun Lee, Jungwoon Cho, Hee Jun Lee, Hee Gu Min, Sang-Hyun Choi, Inpyo Jung, Haiyoung |
author_facet | Kim, Dong Oh Byun, Jae-Eun Kim, Won Sam Kim, Mi Jeong Choi, Jung Ha Kim, Hanna Choi, Eunji Kim, Tae-Don Yoon, Suk Ran Noh, Ji-Yoon Park, Young-Jun Lee, Jungwoon Cho, Hee Jun Lee, Hee Gu Min, Sang-Hyun Choi, Inpyo Jung, Haiyoung |
author_sort | Kim, Dong Oh |
collection | PubMed |
description | The function of natural killer (NK) cell-derived interferon-γ (IFN-γ) expands to remove pathogens by increasing the ability of innate immune cells. Here, we identified the critical role of thioredoxin-interacting protein (TXNIP) in the production of IFN-γ in NK cells during bacterial infection. TXNIP inhibited the production of IFN-γ and the activation of transforming growth factor β-activated kinase 1 (TAK1) activity in primary mouse and human NK cells. TXNIP directly interacted with TAK1 and inhibited TAK1 activity by interfering with the complex formation between TAK1 and TAK1 binding protein 1 (TAB1). Txnip(−/−) (KO) NK cells enhanced the activation of macrophages by inducing IFN-γ production during Pam3CSK4 stimulation or Staphylococcus aureus (S. aureus) infection and contributed to expedite the bacterial clearance. Our findings suggest that NK cell-derived IFN-γ is critical for host defense and that TXNIP plays an important role as an inhibitor of NK cell-mediated macrophage activation by inhibiting the production of IFN-γ during bacterial infection. |
format | Online Article Text |
id | pubmed-7765025 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77650252020-12-27 TXNIP Regulates Natural Killer Cell-Mediated Innate Immunity by Inhibiting IFN-γ Production during Bacterial Infection Kim, Dong Oh Byun, Jae-Eun Kim, Won Sam Kim, Mi Jeong Choi, Jung Ha Kim, Hanna Choi, Eunji Kim, Tae-Don Yoon, Suk Ran Noh, Ji-Yoon Park, Young-Jun Lee, Jungwoon Cho, Hee Jun Lee, Hee Gu Min, Sang-Hyun Choi, Inpyo Jung, Haiyoung Int J Mol Sci Article The function of natural killer (NK) cell-derived interferon-γ (IFN-γ) expands to remove pathogens by increasing the ability of innate immune cells. Here, we identified the critical role of thioredoxin-interacting protein (TXNIP) in the production of IFN-γ in NK cells during bacterial infection. TXNIP inhibited the production of IFN-γ and the activation of transforming growth factor β-activated kinase 1 (TAK1) activity in primary mouse and human NK cells. TXNIP directly interacted with TAK1 and inhibited TAK1 activity by interfering with the complex formation between TAK1 and TAK1 binding protein 1 (TAB1). Txnip(−/−) (KO) NK cells enhanced the activation of macrophages by inducing IFN-γ production during Pam3CSK4 stimulation or Staphylococcus aureus (S. aureus) infection and contributed to expedite the bacterial clearance. Our findings suggest that NK cell-derived IFN-γ is critical for host defense and that TXNIP plays an important role as an inhibitor of NK cell-mediated macrophage activation by inhibiting the production of IFN-γ during bacterial infection. MDPI 2020-12-14 /pmc/articles/PMC7765025/ /pubmed/33327533 http://dx.doi.org/10.3390/ijms21249499 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kim, Dong Oh Byun, Jae-Eun Kim, Won Sam Kim, Mi Jeong Choi, Jung Ha Kim, Hanna Choi, Eunji Kim, Tae-Don Yoon, Suk Ran Noh, Ji-Yoon Park, Young-Jun Lee, Jungwoon Cho, Hee Jun Lee, Hee Gu Min, Sang-Hyun Choi, Inpyo Jung, Haiyoung TXNIP Regulates Natural Killer Cell-Mediated Innate Immunity by Inhibiting IFN-γ Production during Bacterial Infection |
title | TXNIP Regulates Natural Killer Cell-Mediated Innate Immunity by Inhibiting IFN-γ Production during Bacterial Infection |
title_full | TXNIP Regulates Natural Killer Cell-Mediated Innate Immunity by Inhibiting IFN-γ Production during Bacterial Infection |
title_fullStr | TXNIP Regulates Natural Killer Cell-Mediated Innate Immunity by Inhibiting IFN-γ Production during Bacterial Infection |
title_full_unstemmed | TXNIP Regulates Natural Killer Cell-Mediated Innate Immunity by Inhibiting IFN-γ Production during Bacterial Infection |
title_short | TXNIP Regulates Natural Killer Cell-Mediated Innate Immunity by Inhibiting IFN-γ Production during Bacterial Infection |
title_sort | txnip regulates natural killer cell-mediated innate immunity by inhibiting ifn-γ production during bacterial infection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765025/ https://www.ncbi.nlm.nih.gov/pubmed/33327533 http://dx.doi.org/10.3390/ijms21249499 |
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