A Survey of Synthetic Routes and Antitumor Activities for Benzo[g]quinoxaline-5,10-diones

Anthracycline antibiotics play an important role in cancer chemotherapy. The need to improve their therapeutic index has stimulated an ongoing search for anthracycline analogs with enhanced properties. This review aims to summarize the common synthetic approaches to benzo[g]quinoxaline-5,10-diones a...

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Detalles Bibliográficos
Autores principales: Giuglio-Tonolo, Alain G., Curti, Christophe, Terme, Thierry, Vanelle, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765027/
https://www.ncbi.nlm.nih.gov/pubmed/33327601
http://dx.doi.org/10.3390/molecules25245922
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author Giuglio-Tonolo, Alain G.
Curti, Christophe
Terme, Thierry
Vanelle, Patrice
author_facet Giuglio-Tonolo, Alain G.
Curti, Christophe
Terme, Thierry
Vanelle, Patrice
author_sort Giuglio-Tonolo, Alain G.
collection PubMed
description Anthracycline antibiotics play an important role in cancer chemotherapy. The need to improve their therapeutic index has stimulated an ongoing search for anthracycline analogs with enhanced properties. This review aims to summarize the common synthetic approaches to benzo[g]quinoxaline-5,10-diones and their uses in heterocyclic chemistry. Because of the valuable biological activities of the 1,4-diazaanthraquinone compounds, a summary of the most promising heterocyclic quinones is provided together with their antitumor properties.
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spelling pubmed-77650272020-12-27 A Survey of Synthetic Routes and Antitumor Activities for Benzo[g]quinoxaline-5,10-diones Giuglio-Tonolo, Alain G. Curti, Christophe Terme, Thierry Vanelle, Patrice Molecules Review Anthracycline antibiotics play an important role in cancer chemotherapy. The need to improve their therapeutic index has stimulated an ongoing search for anthracycline analogs with enhanced properties. This review aims to summarize the common synthetic approaches to benzo[g]quinoxaline-5,10-diones and their uses in heterocyclic chemistry. Because of the valuable biological activities of the 1,4-diazaanthraquinone compounds, a summary of the most promising heterocyclic quinones is provided together with their antitumor properties. MDPI 2020-12-14 /pmc/articles/PMC7765027/ /pubmed/33327601 http://dx.doi.org/10.3390/molecules25245922 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Giuglio-Tonolo, Alain G.
Curti, Christophe
Terme, Thierry
Vanelle, Patrice
A Survey of Synthetic Routes and Antitumor Activities for Benzo[g]quinoxaline-5,10-diones
title A Survey of Synthetic Routes and Antitumor Activities for Benzo[g]quinoxaline-5,10-diones
title_full A Survey of Synthetic Routes and Antitumor Activities for Benzo[g]quinoxaline-5,10-diones
title_fullStr A Survey of Synthetic Routes and Antitumor Activities for Benzo[g]quinoxaline-5,10-diones
title_full_unstemmed A Survey of Synthetic Routes and Antitumor Activities for Benzo[g]quinoxaline-5,10-diones
title_short A Survey of Synthetic Routes and Antitumor Activities for Benzo[g]quinoxaline-5,10-diones
title_sort survey of synthetic routes and antitumor activities for benzo[g]quinoxaline-5,10-diones
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765027/
https://www.ncbi.nlm.nih.gov/pubmed/33327601
http://dx.doi.org/10.3390/molecules25245922
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