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Isoflurane Potentiation of GABA(A) Receptors Is Reduced but Not Eliminated by the β3(N265M) Mutation

Background: Mice carrying the GABA(A) receptor β3(N265M) point mutation, which renders receptors incorporating β3-subunits insensitive to many general anesthetics, have been used experimentally to link modulation of different receptor subtypes to distinct behavioral endpoints. Remarkably, however, t...

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Detalles Bibliográficos
Autores principales: Lor, Chong, Perouansky, Misha, Pearce, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765171/
https://www.ncbi.nlm.nih.gov/pubmed/33333797
http://dx.doi.org/10.3390/ijms21249534