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Can MRI Biomarkers Predict Triple-Negative Breast Cancer?
The purpose of this study was to investigate MRI features of triple-negative breast cancer (TNBC) compared with non-TNBC, to predict histopathological results. In the study, 26 patients with TNBC and 24 with non-TNBC who underwent multiparametric MRI of the breast on a 3 T magnet over a 10-months pe...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765199/ https://www.ncbi.nlm.nih.gov/pubmed/33333733 http://dx.doi.org/10.3390/diagnostics10121090 |
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author | Moffa, Giuliana Galati, Francesca Collalunga, Emmanuel Rizzo, Veronica Kripa, Endi D’Amati, Giulia Pediconi, Federica |
author_facet | Moffa, Giuliana Galati, Francesca Collalunga, Emmanuel Rizzo, Veronica Kripa, Endi D’Amati, Giulia Pediconi, Federica |
author_sort | Moffa, Giuliana |
collection | PubMed |
description | The purpose of this study was to investigate MRI features of triple-negative breast cancer (TNBC) compared with non-TNBC, to predict histopathological results. In the study, 26 patients with TNBC and 24 with non-TNBC who underwent multiparametric MRI of the breast on a 3 T magnet over a 10-months period were retrospectively recruited. MR imaging sets were evaluated by two experienced breast radiologists in consensus and classified according to the 2013 American College of Radiology (ACR) BI-RADS lexicon. The comparison between the two groups was performed using the Chi-square test and followed by logistic regression analyses. We found that 92% of tumors presented as mass enhancements (p = 0.192). 41.7% of TNBC and 86.4% of non-TNBC had irregular shape (p = 0.005); 58.3% of TNBC showed circumscribed margins, compared to 9.1% of non-TNBC masses (p = 0.001); 75% of TNBC and 9.1% of non-TNBC showed rim enhancement (p < 0.001). Intralesional necrosis was significantly associated with TNBC (p = 0.016). Rim enhancement and intralesional necrosis risulted to be positive predictors at univariate analysis (OR = 29.86, and 8.10, respectively) and the multivariate analysis confirmed that rim enhancement is independently associated with TNBC (OR = 33.08). The mean ADC values were significantly higher for TNBC (p = 0.011). In conclusion, TNBC is associated with specific MRI features that can be possible predictors of pathological results, with a consequent prognostic value. |
format | Online Article Text |
id | pubmed-7765199 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77651992020-12-27 Can MRI Biomarkers Predict Triple-Negative Breast Cancer? Moffa, Giuliana Galati, Francesca Collalunga, Emmanuel Rizzo, Veronica Kripa, Endi D’Amati, Giulia Pediconi, Federica Diagnostics (Basel) Article The purpose of this study was to investigate MRI features of triple-negative breast cancer (TNBC) compared with non-TNBC, to predict histopathological results. In the study, 26 patients with TNBC and 24 with non-TNBC who underwent multiparametric MRI of the breast on a 3 T magnet over a 10-months period were retrospectively recruited. MR imaging sets were evaluated by two experienced breast radiologists in consensus and classified according to the 2013 American College of Radiology (ACR) BI-RADS lexicon. The comparison between the two groups was performed using the Chi-square test and followed by logistic regression analyses. We found that 92% of tumors presented as mass enhancements (p = 0.192). 41.7% of TNBC and 86.4% of non-TNBC had irregular shape (p = 0.005); 58.3% of TNBC showed circumscribed margins, compared to 9.1% of non-TNBC masses (p = 0.001); 75% of TNBC and 9.1% of non-TNBC showed rim enhancement (p < 0.001). Intralesional necrosis was significantly associated with TNBC (p = 0.016). Rim enhancement and intralesional necrosis risulted to be positive predictors at univariate analysis (OR = 29.86, and 8.10, respectively) and the multivariate analysis confirmed that rim enhancement is independently associated with TNBC (OR = 33.08). The mean ADC values were significantly higher for TNBC (p = 0.011). In conclusion, TNBC is associated with specific MRI features that can be possible predictors of pathological results, with a consequent prognostic value. MDPI 2020-12-15 /pmc/articles/PMC7765199/ /pubmed/33333733 http://dx.doi.org/10.3390/diagnostics10121090 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Moffa, Giuliana Galati, Francesca Collalunga, Emmanuel Rizzo, Veronica Kripa, Endi D’Amati, Giulia Pediconi, Federica Can MRI Biomarkers Predict Triple-Negative Breast Cancer? |
title | Can MRI Biomarkers Predict Triple-Negative Breast Cancer? |
title_full | Can MRI Biomarkers Predict Triple-Negative Breast Cancer? |
title_fullStr | Can MRI Biomarkers Predict Triple-Negative Breast Cancer? |
title_full_unstemmed | Can MRI Biomarkers Predict Triple-Negative Breast Cancer? |
title_short | Can MRI Biomarkers Predict Triple-Negative Breast Cancer? |
title_sort | can mri biomarkers predict triple-negative breast cancer? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765199/ https://www.ncbi.nlm.nih.gov/pubmed/33333733 http://dx.doi.org/10.3390/diagnostics10121090 |
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