Next Generation Sequencing in Non-Small Cell Lung Cancer: Pitfalls and Opportunities

Lung cancer remains the first cause of cancer-related deaths worldwide. Thanks to the improvement in the knowledge of the biology of non-small cell lung cancer (NSCLC), patients’ survival has significantly improved. A growing number of targetable molecular alterations have been identified. Next-gene...

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Autores principales: Lazzari, Chiara, Bulotta, Alessandra, Cangi, Maria Giulia, Bucci, Gabriele, Pecciarini, Lorenza, Bonfiglio, Silvia, Lorusso, Vincenza, Ippati, Stefania, Arrigoni, Gianluigi, Grassini, Greta, Doglioni, Claudio, Gregorc, Vanesa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765222/
https://www.ncbi.nlm.nih.gov/pubmed/33333743
http://dx.doi.org/10.3390/diagnostics10121092
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author Lazzari, Chiara
Bulotta, Alessandra
Cangi, Maria Giulia
Bucci, Gabriele
Pecciarini, Lorenza
Bonfiglio, Silvia
Lorusso, Vincenza
Ippati, Stefania
Arrigoni, Gianluigi
Grassini, Greta
Doglioni, Claudio
Gregorc, Vanesa
author_facet Lazzari, Chiara
Bulotta, Alessandra
Cangi, Maria Giulia
Bucci, Gabriele
Pecciarini, Lorenza
Bonfiglio, Silvia
Lorusso, Vincenza
Ippati, Stefania
Arrigoni, Gianluigi
Grassini, Greta
Doglioni, Claudio
Gregorc, Vanesa
author_sort Lazzari, Chiara
collection PubMed
description Lung cancer remains the first cause of cancer-related deaths worldwide. Thanks to the improvement in the knowledge of the biology of non-small cell lung cancer (NSCLC), patients’ survival has significantly improved. A growing number of targetable molecular alterations have been identified. Next-generation sequencing (NGS) has become one of the methodologies entered in clinical practice and was recently recommended by the European society for medical oncology (ESMO) to perform a comprehensive molecular characterization in patients with cancer. The current review provides an overview of the clinical trials that have explored the impact of NGS in patients with cancer, its limits, and advantages.
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spelling pubmed-77652222020-12-27 Next Generation Sequencing in Non-Small Cell Lung Cancer: Pitfalls and Opportunities Lazzari, Chiara Bulotta, Alessandra Cangi, Maria Giulia Bucci, Gabriele Pecciarini, Lorenza Bonfiglio, Silvia Lorusso, Vincenza Ippati, Stefania Arrigoni, Gianluigi Grassini, Greta Doglioni, Claudio Gregorc, Vanesa Diagnostics (Basel) Review Lung cancer remains the first cause of cancer-related deaths worldwide. Thanks to the improvement in the knowledge of the biology of non-small cell lung cancer (NSCLC), patients’ survival has significantly improved. A growing number of targetable molecular alterations have been identified. Next-generation sequencing (NGS) has become one of the methodologies entered in clinical practice and was recently recommended by the European society for medical oncology (ESMO) to perform a comprehensive molecular characterization in patients with cancer. The current review provides an overview of the clinical trials that have explored the impact of NGS in patients with cancer, its limits, and advantages. MDPI 2020-12-15 /pmc/articles/PMC7765222/ /pubmed/33333743 http://dx.doi.org/10.3390/diagnostics10121092 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lazzari, Chiara
Bulotta, Alessandra
Cangi, Maria Giulia
Bucci, Gabriele
Pecciarini, Lorenza
Bonfiglio, Silvia
Lorusso, Vincenza
Ippati, Stefania
Arrigoni, Gianluigi
Grassini, Greta
Doglioni, Claudio
Gregorc, Vanesa
Next Generation Sequencing in Non-Small Cell Lung Cancer: Pitfalls and Opportunities
title Next Generation Sequencing in Non-Small Cell Lung Cancer: Pitfalls and Opportunities
title_full Next Generation Sequencing in Non-Small Cell Lung Cancer: Pitfalls and Opportunities
title_fullStr Next Generation Sequencing in Non-Small Cell Lung Cancer: Pitfalls and Opportunities
title_full_unstemmed Next Generation Sequencing in Non-Small Cell Lung Cancer: Pitfalls and Opportunities
title_short Next Generation Sequencing in Non-Small Cell Lung Cancer: Pitfalls and Opportunities
title_sort next generation sequencing in non-small cell lung cancer: pitfalls and opportunities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765222/
https://www.ncbi.nlm.nih.gov/pubmed/33333743
http://dx.doi.org/10.3390/diagnostics10121092
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