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Outcomes in Pediatric Acute Lymphoblastic Leukemia—A Single-Center Romanian Experience
Background: This study evaluates the main (para)clinical aspects and outcomes in a group of Romanian children diagnosed with acute lymphoblastic leukemia (ALL), under the conditions of antileukemic treatment according to an adapted ALL IC Berlin–Frankfurt–Munster (BFM) 2002 protocol. Methods: We per...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765371/ https://www.ncbi.nlm.nih.gov/pubmed/33333966 http://dx.doi.org/10.3390/jcm9124052 |
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author | Alecsa, Mirabela-Smaranda Moscalu, Mihaela Trandafir, Laura-Mihaela Ivanov, Anca-Viorica Rusu, Cristina Miron, Ingrith-Crenguta |
author_facet | Alecsa, Mirabela-Smaranda Moscalu, Mihaela Trandafir, Laura-Mihaela Ivanov, Anca-Viorica Rusu, Cristina Miron, Ingrith-Crenguta |
author_sort | Alecsa, Mirabela-Smaranda |
collection | PubMed |
description | Background: This study evaluates the main (para)clinical aspects and outcomes in a group of Romanian children diagnosed with acute lymphoblastic leukemia (ALL), under the conditions of antileukemic treatment according to an adapted ALL IC Berlin–Frankfurt–Munster (BFM) 2002 protocol. Methods: We performed a retrospective single-center study of 125 children diagnosed with ALL between 2010 and 2016. Standard forms were used for data collection of variate clinical and paraclinical parameters. Results: The children were predominantly male (64.8%) and their median age at diagnosis was 5 years. A total of 107 patients were diagnosed with precursor B-cell acute lymphoblastic leukemia (BCP)-ALL and 18 with T-cell acute lymphoblastic leukemia T-ALL. Multiplex reverse transcription polymerase chain reaction RT-PCR assay for ETV6-RUNX1, BCR-ABL, E2A-PBX1, KMT2A-AFF1, and STIL-TAL1 fusion genes was performed in 111 patients. ETV6-RUNX1 translocation was detected in 18.9% of patients, while BCR-ABL1 and E2A-PBX1 rearrangements were seen in 2.7% and 3.6%, respectively. Complete remission at the end of induction phase was obtained in 89.6% of patients. The overall relapse rate was 11.2%, with 11 early and 3 late relapses. The 5-year overall survival rate in BCP-ALL was 81.6% and in T-ALL 71.4%. Conclusions: The 5-year overall and event-free survival rates in our study were slightly lower than those reported in developed countries, so the patients’ outcomes are encouraging. |
format | Online Article Text |
id | pubmed-7765371 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77653712020-12-27 Outcomes in Pediatric Acute Lymphoblastic Leukemia—A Single-Center Romanian Experience Alecsa, Mirabela-Smaranda Moscalu, Mihaela Trandafir, Laura-Mihaela Ivanov, Anca-Viorica Rusu, Cristina Miron, Ingrith-Crenguta J Clin Med Article Background: This study evaluates the main (para)clinical aspects and outcomes in a group of Romanian children diagnosed with acute lymphoblastic leukemia (ALL), under the conditions of antileukemic treatment according to an adapted ALL IC Berlin–Frankfurt–Munster (BFM) 2002 protocol. Methods: We performed a retrospective single-center study of 125 children diagnosed with ALL between 2010 and 2016. Standard forms were used for data collection of variate clinical and paraclinical parameters. Results: The children were predominantly male (64.8%) and their median age at diagnosis was 5 years. A total of 107 patients were diagnosed with precursor B-cell acute lymphoblastic leukemia (BCP)-ALL and 18 with T-cell acute lymphoblastic leukemia T-ALL. Multiplex reverse transcription polymerase chain reaction RT-PCR assay for ETV6-RUNX1, BCR-ABL, E2A-PBX1, KMT2A-AFF1, and STIL-TAL1 fusion genes was performed in 111 patients. ETV6-RUNX1 translocation was detected in 18.9% of patients, while BCR-ABL1 and E2A-PBX1 rearrangements were seen in 2.7% and 3.6%, respectively. Complete remission at the end of induction phase was obtained in 89.6% of patients. The overall relapse rate was 11.2%, with 11 early and 3 late relapses. The 5-year overall survival rate in BCP-ALL was 81.6% and in T-ALL 71.4%. Conclusions: The 5-year overall and event-free survival rates in our study were slightly lower than those reported in developed countries, so the patients’ outcomes are encouraging. MDPI 2020-12-15 /pmc/articles/PMC7765371/ /pubmed/33333966 http://dx.doi.org/10.3390/jcm9124052 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Alecsa, Mirabela-Smaranda Moscalu, Mihaela Trandafir, Laura-Mihaela Ivanov, Anca-Viorica Rusu, Cristina Miron, Ingrith-Crenguta Outcomes in Pediatric Acute Lymphoblastic Leukemia—A Single-Center Romanian Experience |
title | Outcomes in Pediatric Acute Lymphoblastic Leukemia—A Single-Center Romanian Experience |
title_full | Outcomes in Pediatric Acute Lymphoblastic Leukemia—A Single-Center Romanian Experience |
title_fullStr | Outcomes in Pediatric Acute Lymphoblastic Leukemia—A Single-Center Romanian Experience |
title_full_unstemmed | Outcomes in Pediatric Acute Lymphoblastic Leukemia—A Single-Center Romanian Experience |
title_short | Outcomes in Pediatric Acute Lymphoblastic Leukemia—A Single-Center Romanian Experience |
title_sort | outcomes in pediatric acute lymphoblastic leukemia—a single-center romanian experience |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765371/ https://www.ncbi.nlm.nih.gov/pubmed/33333966 http://dx.doi.org/10.3390/jcm9124052 |
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