Cargando…

Outcomes in Pediatric Acute Lymphoblastic Leukemia—A Single-Center Romanian Experience

Background: This study evaluates the main (para)clinical aspects and outcomes in a group of Romanian children diagnosed with acute lymphoblastic leukemia (ALL), under the conditions of antileukemic treatment according to an adapted ALL IC Berlin–Frankfurt–Munster (BFM) 2002 protocol. Methods: We per...

Descripción completa

Detalles Bibliográficos
Autores principales: Alecsa, Mirabela-Smaranda, Moscalu, Mihaela, Trandafir, Laura-Mihaela, Ivanov, Anca-Viorica, Rusu, Cristina, Miron, Ingrith-Crenguta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765371/
https://www.ncbi.nlm.nih.gov/pubmed/33333966
http://dx.doi.org/10.3390/jcm9124052
_version_ 1783628474976567296
author Alecsa, Mirabela-Smaranda
Moscalu, Mihaela
Trandafir, Laura-Mihaela
Ivanov, Anca-Viorica
Rusu, Cristina
Miron, Ingrith-Crenguta
author_facet Alecsa, Mirabela-Smaranda
Moscalu, Mihaela
Trandafir, Laura-Mihaela
Ivanov, Anca-Viorica
Rusu, Cristina
Miron, Ingrith-Crenguta
author_sort Alecsa, Mirabela-Smaranda
collection PubMed
description Background: This study evaluates the main (para)clinical aspects and outcomes in a group of Romanian children diagnosed with acute lymphoblastic leukemia (ALL), under the conditions of antileukemic treatment according to an adapted ALL IC Berlin–Frankfurt–Munster (BFM) 2002 protocol. Methods: We performed a retrospective single-center study of 125 children diagnosed with ALL between 2010 and 2016. Standard forms were used for data collection of variate clinical and paraclinical parameters. Results: The children were predominantly male (64.8%) and their median age at diagnosis was 5 years. A total of 107 patients were diagnosed with precursor B-cell acute lymphoblastic leukemia (BCP)-ALL and 18 with T-cell acute lymphoblastic leukemia T-ALL. Multiplex reverse transcription polymerase chain reaction RT-PCR assay for ETV6-RUNX1, BCR-ABL, E2A-PBX1, KMT2A-AFF1, and STIL-TAL1 fusion genes was performed in 111 patients. ETV6-RUNX1 translocation was detected in 18.9% of patients, while BCR-ABL1 and E2A-PBX1 rearrangements were seen in 2.7% and 3.6%, respectively. Complete remission at the end of induction phase was obtained in 89.6% of patients. The overall relapse rate was 11.2%, with 11 early and 3 late relapses. The 5-year overall survival rate in BCP-ALL was 81.6% and in T-ALL 71.4%. Conclusions: The 5-year overall and event-free survival rates in our study were slightly lower than those reported in developed countries, so the patients’ outcomes are encouraging.
format Online
Article
Text
id pubmed-7765371
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-77653712020-12-27 Outcomes in Pediatric Acute Lymphoblastic Leukemia—A Single-Center Romanian Experience Alecsa, Mirabela-Smaranda Moscalu, Mihaela Trandafir, Laura-Mihaela Ivanov, Anca-Viorica Rusu, Cristina Miron, Ingrith-Crenguta J Clin Med Article Background: This study evaluates the main (para)clinical aspects and outcomes in a group of Romanian children diagnosed with acute lymphoblastic leukemia (ALL), under the conditions of antileukemic treatment according to an adapted ALL IC Berlin–Frankfurt–Munster (BFM) 2002 protocol. Methods: We performed a retrospective single-center study of 125 children diagnosed with ALL between 2010 and 2016. Standard forms were used for data collection of variate clinical and paraclinical parameters. Results: The children were predominantly male (64.8%) and their median age at diagnosis was 5 years. A total of 107 patients were diagnosed with precursor B-cell acute lymphoblastic leukemia (BCP)-ALL and 18 with T-cell acute lymphoblastic leukemia T-ALL. Multiplex reverse transcription polymerase chain reaction RT-PCR assay for ETV6-RUNX1, BCR-ABL, E2A-PBX1, KMT2A-AFF1, and STIL-TAL1 fusion genes was performed in 111 patients. ETV6-RUNX1 translocation was detected in 18.9% of patients, while BCR-ABL1 and E2A-PBX1 rearrangements were seen in 2.7% and 3.6%, respectively. Complete remission at the end of induction phase was obtained in 89.6% of patients. The overall relapse rate was 11.2%, with 11 early and 3 late relapses. The 5-year overall survival rate in BCP-ALL was 81.6% and in T-ALL 71.4%. Conclusions: The 5-year overall and event-free survival rates in our study were slightly lower than those reported in developed countries, so the patients’ outcomes are encouraging. MDPI 2020-12-15 /pmc/articles/PMC7765371/ /pubmed/33333966 http://dx.doi.org/10.3390/jcm9124052 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alecsa, Mirabela-Smaranda
Moscalu, Mihaela
Trandafir, Laura-Mihaela
Ivanov, Anca-Viorica
Rusu, Cristina
Miron, Ingrith-Crenguta
Outcomes in Pediatric Acute Lymphoblastic Leukemia—A Single-Center Romanian Experience
title Outcomes in Pediatric Acute Lymphoblastic Leukemia—A Single-Center Romanian Experience
title_full Outcomes in Pediatric Acute Lymphoblastic Leukemia—A Single-Center Romanian Experience
title_fullStr Outcomes in Pediatric Acute Lymphoblastic Leukemia—A Single-Center Romanian Experience
title_full_unstemmed Outcomes in Pediatric Acute Lymphoblastic Leukemia—A Single-Center Romanian Experience
title_short Outcomes in Pediatric Acute Lymphoblastic Leukemia—A Single-Center Romanian Experience
title_sort outcomes in pediatric acute lymphoblastic leukemia—a single-center romanian experience
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765371/
https://www.ncbi.nlm.nih.gov/pubmed/33333966
http://dx.doi.org/10.3390/jcm9124052
work_keys_str_mv AT alecsamirabelasmaranda outcomesinpediatricacutelymphoblasticleukemiaasinglecenterromanianexperience
AT moscalumihaela outcomesinpediatricacutelymphoblasticleukemiaasinglecenterromanianexperience
AT trandafirlauramihaela outcomesinpediatricacutelymphoblasticleukemiaasinglecenterromanianexperience
AT ivanovancaviorica outcomesinpediatricacutelymphoblasticleukemiaasinglecenterromanianexperience
AT rusucristina outcomesinpediatricacutelymphoblasticleukemiaasinglecenterromanianexperience
AT mironingrithcrenguta outcomesinpediatricacutelymphoblasticleukemiaasinglecenterromanianexperience