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Vaccination Criteria Based on Factors Influencing COVID-19 Diffusion and Mortality

SARS-CoV-2 is highly contagious, rapidly turned into a pandemic, and is causing a relevant number of critical to severe life-threatening COVID-19 patients. However, robust statistical studies of a large cohort of patients, potentially useful to implement a vaccination campaign, are rare. We analyzed...

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Autores principales: Spassiani, Ilaria, Gubian, Lorenzo, Palù, Giorgio, Sebastiani, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765372/
https://www.ncbi.nlm.nih.gov/pubmed/33334007
http://dx.doi.org/10.3390/vaccines8040766
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author Spassiani, Ilaria
Gubian, Lorenzo
Palù, Giorgio
Sebastiani, Giovanni
author_facet Spassiani, Ilaria
Gubian, Lorenzo
Palù, Giorgio
Sebastiani, Giovanni
author_sort Spassiani, Ilaria
collection PubMed
description SARS-CoV-2 is highly contagious, rapidly turned into a pandemic, and is causing a relevant number of critical to severe life-threatening COVID-19 patients. However, robust statistical studies of a large cohort of patients, potentially useful to implement a vaccination campaign, are rare. We analyzed public data of about 19,000 patients for the period 28 February to 15 May 2020 by several mathematical methods. Precisely, we describe the COVID-19 evolution of a number of variables that include age, gender, patient’s care location, and comorbidities. It prompts consideration of special preventive and therapeutic measures for subjects more prone to developing life-threatening conditions while affording quantitative parameters for predicting the effects of an outburst of the pandemic on public health structures and facilities adopted in response. We propose a mathematical way to use these results as a powerful tool to face the pandemic and implement a mass vaccination campaign. This is done by means of priority criteria based on the influence of the considered variables on the probability of both death and infection.
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spelling pubmed-77653722020-12-27 Vaccination Criteria Based on Factors Influencing COVID-19 Diffusion and Mortality Spassiani, Ilaria Gubian, Lorenzo Palù, Giorgio Sebastiani, Giovanni Vaccines (Basel) Article SARS-CoV-2 is highly contagious, rapidly turned into a pandemic, and is causing a relevant number of critical to severe life-threatening COVID-19 patients. However, robust statistical studies of a large cohort of patients, potentially useful to implement a vaccination campaign, are rare. We analyzed public data of about 19,000 patients for the period 28 February to 15 May 2020 by several mathematical methods. Precisely, we describe the COVID-19 evolution of a number of variables that include age, gender, patient’s care location, and comorbidities. It prompts consideration of special preventive and therapeutic measures for subjects more prone to developing life-threatening conditions while affording quantitative parameters for predicting the effects of an outburst of the pandemic on public health structures and facilities adopted in response. We propose a mathematical way to use these results as a powerful tool to face the pandemic and implement a mass vaccination campaign. This is done by means of priority criteria based on the influence of the considered variables on the probability of both death and infection. MDPI 2020-12-15 /pmc/articles/PMC7765372/ /pubmed/33334007 http://dx.doi.org/10.3390/vaccines8040766 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Spassiani, Ilaria
Gubian, Lorenzo
Palù, Giorgio
Sebastiani, Giovanni
Vaccination Criteria Based on Factors Influencing COVID-19 Diffusion and Mortality
title Vaccination Criteria Based on Factors Influencing COVID-19 Diffusion and Mortality
title_full Vaccination Criteria Based on Factors Influencing COVID-19 Diffusion and Mortality
title_fullStr Vaccination Criteria Based on Factors Influencing COVID-19 Diffusion and Mortality
title_full_unstemmed Vaccination Criteria Based on Factors Influencing COVID-19 Diffusion and Mortality
title_short Vaccination Criteria Based on Factors Influencing COVID-19 Diffusion and Mortality
title_sort vaccination criteria based on factors influencing covid-19 diffusion and mortality
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765372/
https://www.ncbi.nlm.nih.gov/pubmed/33334007
http://dx.doi.org/10.3390/vaccines8040766
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