Pluripotent Stem Cell-Derived Hepatocytes Phenotypic Screening Reveals Small Molecules Targeting the CDK2/4-C/EBPα/DGAT2 Pathway Preventing ER-Stress Induced Lipid Accumulation

Non-alcoholic fatty liver disease (NAFLD) has a large impact on global health. At the onset of disease, NAFLD is characterized by hepatic steatosis defined by the accumulation of triglycerides stored as lipid droplets. Developing therapeutics against NAFLD and progression to non-alcoholic steatohepa...

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Detalles Bibliográficos
Autores principales: Parafati, Maddalena, Bae, Sang Hyo, Kirby, R. Jason, Fitzek, Martina, Iyer, Preeti, Engkvist, Ola, Smith, David M., Malany, Siobhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765409/
https://www.ncbi.nlm.nih.gov/pubmed/33334026
http://dx.doi.org/10.3390/ijms21249557

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