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Associations between Clinical Symptoms and Degree of Ossification in Patients with Cervical Ossification of the Posterior Longitudinal Ligament: A Prospective Multi-Institutional Cross-Sectional Study
This study aimed to clarify whether ossification predisposition influences clinical symptoms including pain, restriction of activities of daily living, and quality of life in patients with cervical ossification of the posterior longitudinal ligament (OPLL). Cervical ossification predisposition poten...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765525/ https://www.ncbi.nlm.nih.gov/pubmed/33334036 http://dx.doi.org/10.3390/jcm9124055 |
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author | Hirai, Takashi Yoshii, Toshitaka Ushio, Shuta Hashimoto, Jun Mori, Kanji Maki, Satoshi Katsumi, Keiichi Nagoshi, Narihito Takeuchi, Kazuhiro Furuya, Takeo Watanabe, Kei Nishida, Norihiro Nishimura, Soraya Watanabe, Kota Kaito, Takashi Kato, Satoshi Nagashima, Katsuya Koda, Masao Ito, Kenyu Imagama, Shiro Matsuoka, Yuji Wada, Kanichiro Kimura, Atsushi Ohba, Tetsuro Katoh, Hiroyuki Watanabe, Masahiko Matsuyama, Yukihiro Ozawa, Hiroshi Haro, Hirotaka Takeshita, Katsushi Matsumoto, Morio Nakamura, Masaya Yamazaki, Masashi Yuasa, Masato Inose, Hiroyuki Okawa, Atsushi Kawaguchi, Yoshiharu |
author_facet | Hirai, Takashi Yoshii, Toshitaka Ushio, Shuta Hashimoto, Jun Mori, Kanji Maki, Satoshi Katsumi, Keiichi Nagoshi, Narihito Takeuchi, Kazuhiro Furuya, Takeo Watanabe, Kei Nishida, Norihiro Nishimura, Soraya Watanabe, Kota Kaito, Takashi Kato, Satoshi Nagashima, Katsuya Koda, Masao Ito, Kenyu Imagama, Shiro Matsuoka, Yuji Wada, Kanichiro Kimura, Atsushi Ohba, Tetsuro Katoh, Hiroyuki Watanabe, Masahiko Matsuyama, Yukihiro Ozawa, Hiroshi Haro, Hirotaka Takeshita, Katsushi Matsumoto, Morio Nakamura, Masaya Yamazaki, Masashi Yuasa, Masato Inose, Hiroyuki Okawa, Atsushi Kawaguchi, Yoshiharu |
author_sort | Hirai, Takashi |
collection | PubMed |
description | This study aimed to clarify whether ossification predisposition influences clinical symptoms including pain, restriction of activities of daily living, and quality of life in patients with cervical ossification of the posterior longitudinal ligament (OPLL). Cervical ossification predisposition potentially causes neurologic dysfunction, but the relationship between clinical symptoms and radiologic severity of OPLL has not yet been investigated. Data were prospectively collected from 16 institutions across Japan. We enrolled 239 patients with cervical OPLL. The primary outcomes were patient-reported outcomes, including visual analog scale (VAS) pain scores and other questionnaires. Whole-spine computed tomography images were obtained, and correlations were investigated between clinical symptoms and radiologic findings, including the distribution of OPLL, the sum of the levels where OPLL was present (OP-index), and the canal narrowing ratio (CNR) grade. The cervical OP-index was Grade 1 in 113 patients, Grade 2 in 90, and Grade 3 in 36. No significant correlations were found between radiologic outcomes and VAS pain scores. The cervical OP-index was associated with lower extremity function, social dysfunction, and locomotive function. The CNR grade was not correlated with clinical symptoms, but Grade 4 was associated with lower extremity dysfunction. Thickness and extension of ossified lesions may be associated with lower extremity dysfunction in cervical OPLL. |
format | Online Article Text |
id | pubmed-7765525 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77655252020-12-27 Associations between Clinical Symptoms and Degree of Ossification in Patients with Cervical Ossification of the Posterior Longitudinal Ligament: A Prospective Multi-Institutional Cross-Sectional Study Hirai, Takashi Yoshii, Toshitaka Ushio, Shuta Hashimoto, Jun Mori, Kanji Maki, Satoshi Katsumi, Keiichi Nagoshi, Narihito Takeuchi, Kazuhiro Furuya, Takeo Watanabe, Kei Nishida, Norihiro Nishimura, Soraya Watanabe, Kota Kaito, Takashi Kato, Satoshi Nagashima, Katsuya Koda, Masao Ito, Kenyu Imagama, Shiro Matsuoka, Yuji Wada, Kanichiro Kimura, Atsushi Ohba, Tetsuro Katoh, Hiroyuki Watanabe, Masahiko Matsuyama, Yukihiro Ozawa, Hiroshi Haro, Hirotaka Takeshita, Katsushi Matsumoto, Morio Nakamura, Masaya Yamazaki, Masashi Yuasa, Masato Inose, Hiroyuki Okawa, Atsushi Kawaguchi, Yoshiharu J Clin Med Article This study aimed to clarify whether ossification predisposition influences clinical symptoms including pain, restriction of activities of daily living, and quality of life in patients with cervical ossification of the posterior longitudinal ligament (OPLL). Cervical ossification predisposition potentially causes neurologic dysfunction, but the relationship between clinical symptoms and radiologic severity of OPLL has not yet been investigated. Data were prospectively collected from 16 institutions across Japan. We enrolled 239 patients with cervical OPLL. The primary outcomes were patient-reported outcomes, including visual analog scale (VAS) pain scores and other questionnaires. Whole-spine computed tomography images were obtained, and correlations were investigated between clinical symptoms and radiologic findings, including the distribution of OPLL, the sum of the levels where OPLL was present (OP-index), and the canal narrowing ratio (CNR) grade. The cervical OP-index was Grade 1 in 113 patients, Grade 2 in 90, and Grade 3 in 36. No significant correlations were found between radiologic outcomes and VAS pain scores. The cervical OP-index was associated with lower extremity function, social dysfunction, and locomotive function. The CNR grade was not correlated with clinical symptoms, but Grade 4 was associated with lower extremity dysfunction. Thickness and extension of ossified lesions may be associated with lower extremity dysfunction in cervical OPLL. MDPI 2020-12-15 /pmc/articles/PMC7765525/ /pubmed/33334036 http://dx.doi.org/10.3390/jcm9124055 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hirai, Takashi Yoshii, Toshitaka Ushio, Shuta Hashimoto, Jun Mori, Kanji Maki, Satoshi Katsumi, Keiichi Nagoshi, Narihito Takeuchi, Kazuhiro Furuya, Takeo Watanabe, Kei Nishida, Norihiro Nishimura, Soraya Watanabe, Kota Kaito, Takashi Kato, Satoshi Nagashima, Katsuya Koda, Masao Ito, Kenyu Imagama, Shiro Matsuoka, Yuji Wada, Kanichiro Kimura, Atsushi Ohba, Tetsuro Katoh, Hiroyuki Watanabe, Masahiko Matsuyama, Yukihiro Ozawa, Hiroshi Haro, Hirotaka Takeshita, Katsushi Matsumoto, Morio Nakamura, Masaya Yamazaki, Masashi Yuasa, Masato Inose, Hiroyuki Okawa, Atsushi Kawaguchi, Yoshiharu Associations between Clinical Symptoms and Degree of Ossification in Patients with Cervical Ossification of the Posterior Longitudinal Ligament: A Prospective Multi-Institutional Cross-Sectional Study |
title | Associations between Clinical Symptoms and Degree of Ossification in Patients with Cervical Ossification of the Posterior Longitudinal Ligament: A Prospective Multi-Institutional Cross-Sectional Study |
title_full | Associations between Clinical Symptoms and Degree of Ossification in Patients with Cervical Ossification of the Posterior Longitudinal Ligament: A Prospective Multi-Institutional Cross-Sectional Study |
title_fullStr | Associations between Clinical Symptoms and Degree of Ossification in Patients with Cervical Ossification of the Posterior Longitudinal Ligament: A Prospective Multi-Institutional Cross-Sectional Study |
title_full_unstemmed | Associations between Clinical Symptoms and Degree of Ossification in Patients with Cervical Ossification of the Posterior Longitudinal Ligament: A Prospective Multi-Institutional Cross-Sectional Study |
title_short | Associations between Clinical Symptoms and Degree of Ossification in Patients with Cervical Ossification of the Posterior Longitudinal Ligament: A Prospective Multi-Institutional Cross-Sectional Study |
title_sort | associations between clinical symptoms and degree of ossification in patients with cervical ossification of the posterior longitudinal ligament: a prospective multi-institutional cross-sectional study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765525/ https://www.ncbi.nlm.nih.gov/pubmed/33334036 http://dx.doi.org/10.3390/jcm9124055 |
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