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Building Blocks to Design Liposomal Delivery Systems

The flexibility of liposomal carriers does not just simply rely on their capability to encapsulate various types of therapeutic substances, but also on the large array of components used for designing liposome-based nanoformulations. Each of their components plays a very specific role in the formula...

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Autores principales: Juszkiewicz, Katarzyna, Sikorski, Aleksander F., Czogalla, Aleksander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765547/
https://www.ncbi.nlm.nih.gov/pubmed/33334048
http://dx.doi.org/10.3390/ijms21249559
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author Juszkiewicz, Katarzyna
Sikorski, Aleksander F.
Czogalla, Aleksander
author_facet Juszkiewicz, Katarzyna
Sikorski, Aleksander F.
Czogalla, Aleksander
author_sort Juszkiewicz, Katarzyna
collection PubMed
description The flexibility of liposomal carriers does not just simply rely on their capability to encapsulate various types of therapeutic substances, but also on the large array of components used for designing liposome-based nanoformulations. Each of their components plays a very specific role in the formulation and can be easily replaced whenever a different therapeutic effect is desired. It is tempting to describe this by an analogy to Lego blocks, since a whole set of structures, differing in their features, can be designed using a certain pool of blocks. In this review, we focus on different design strategies, where a broad variety of liposomal components facilitates the attainment of straightforward control over targeting and drug release, which leads to the design of the most promising systems for drug delivery. The key aspects of this block-based architecture became evident after its implementation in our recent works on liposomal carriers of antisense oligonucleotides and statins, which are described in the last chapter of this review.
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spelling pubmed-77655472020-12-27 Building Blocks to Design Liposomal Delivery Systems Juszkiewicz, Katarzyna Sikorski, Aleksander F. Czogalla, Aleksander Int J Mol Sci Review The flexibility of liposomal carriers does not just simply rely on their capability to encapsulate various types of therapeutic substances, but also on the large array of components used for designing liposome-based nanoformulations. Each of their components plays a very specific role in the formulation and can be easily replaced whenever a different therapeutic effect is desired. It is tempting to describe this by an analogy to Lego blocks, since a whole set of structures, differing in their features, can be designed using a certain pool of blocks. In this review, we focus on different design strategies, where a broad variety of liposomal components facilitates the attainment of straightforward control over targeting and drug release, which leads to the design of the most promising systems for drug delivery. The key aspects of this block-based architecture became evident after its implementation in our recent works on liposomal carriers of antisense oligonucleotides and statins, which are described in the last chapter of this review. MDPI 2020-12-15 /pmc/articles/PMC7765547/ /pubmed/33334048 http://dx.doi.org/10.3390/ijms21249559 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Juszkiewicz, Katarzyna
Sikorski, Aleksander F.
Czogalla, Aleksander
Building Blocks to Design Liposomal Delivery Systems
title Building Blocks to Design Liposomal Delivery Systems
title_full Building Blocks to Design Liposomal Delivery Systems
title_fullStr Building Blocks to Design Liposomal Delivery Systems
title_full_unstemmed Building Blocks to Design Liposomal Delivery Systems
title_short Building Blocks to Design Liposomal Delivery Systems
title_sort building blocks to design liposomal delivery systems
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765547/
https://www.ncbi.nlm.nih.gov/pubmed/33334048
http://dx.doi.org/10.3390/ijms21249559
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