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Building Blocks to Design Liposomal Delivery Systems
The flexibility of liposomal carriers does not just simply rely on their capability to encapsulate various types of therapeutic substances, but also on the large array of components used for designing liposome-based nanoformulations. Each of their components plays a very specific role in the formula...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765547/ https://www.ncbi.nlm.nih.gov/pubmed/33334048 http://dx.doi.org/10.3390/ijms21249559 |
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author | Juszkiewicz, Katarzyna Sikorski, Aleksander F. Czogalla, Aleksander |
author_facet | Juszkiewicz, Katarzyna Sikorski, Aleksander F. Czogalla, Aleksander |
author_sort | Juszkiewicz, Katarzyna |
collection | PubMed |
description | The flexibility of liposomal carriers does not just simply rely on their capability to encapsulate various types of therapeutic substances, but also on the large array of components used for designing liposome-based nanoformulations. Each of their components plays a very specific role in the formulation and can be easily replaced whenever a different therapeutic effect is desired. It is tempting to describe this by an analogy to Lego blocks, since a whole set of structures, differing in their features, can be designed using a certain pool of blocks. In this review, we focus on different design strategies, where a broad variety of liposomal components facilitates the attainment of straightforward control over targeting and drug release, which leads to the design of the most promising systems for drug delivery. The key aspects of this block-based architecture became evident after its implementation in our recent works on liposomal carriers of antisense oligonucleotides and statins, which are described in the last chapter of this review. |
format | Online Article Text |
id | pubmed-7765547 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77655472020-12-27 Building Blocks to Design Liposomal Delivery Systems Juszkiewicz, Katarzyna Sikorski, Aleksander F. Czogalla, Aleksander Int J Mol Sci Review The flexibility of liposomal carriers does not just simply rely on their capability to encapsulate various types of therapeutic substances, but also on the large array of components used for designing liposome-based nanoformulations. Each of their components plays a very specific role in the formulation and can be easily replaced whenever a different therapeutic effect is desired. It is tempting to describe this by an analogy to Lego blocks, since a whole set of structures, differing in their features, can be designed using a certain pool of blocks. In this review, we focus on different design strategies, where a broad variety of liposomal components facilitates the attainment of straightforward control over targeting and drug release, which leads to the design of the most promising systems for drug delivery. The key aspects of this block-based architecture became evident after its implementation in our recent works on liposomal carriers of antisense oligonucleotides and statins, which are described in the last chapter of this review. MDPI 2020-12-15 /pmc/articles/PMC7765547/ /pubmed/33334048 http://dx.doi.org/10.3390/ijms21249559 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Juszkiewicz, Katarzyna Sikorski, Aleksander F. Czogalla, Aleksander Building Blocks to Design Liposomal Delivery Systems |
title | Building Blocks to Design Liposomal Delivery Systems |
title_full | Building Blocks to Design Liposomal Delivery Systems |
title_fullStr | Building Blocks to Design Liposomal Delivery Systems |
title_full_unstemmed | Building Blocks to Design Liposomal Delivery Systems |
title_short | Building Blocks to Design Liposomal Delivery Systems |
title_sort | building blocks to design liposomal delivery systems |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765547/ https://www.ncbi.nlm.nih.gov/pubmed/33334048 http://dx.doi.org/10.3390/ijms21249559 |
work_keys_str_mv | AT juszkiewiczkatarzyna buildingblockstodesignliposomaldeliverysystems AT sikorskialeksanderf buildingblockstodesignliposomaldeliverysystems AT czogallaaleksander buildingblockstodesignliposomaldeliverysystems |