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ER–Mitochondria Contacts and Insulin Resistance Modulation through Exercise Intervention
The endoplasmic reticulum (ER) makes physical contacts with mitochondria at specific sites, and the hubs between the two organelles are called mitochondria-associated ER membranes (MAMs). MAMs are known to play key roles in biological processes, such as intracellular Ca(2+) regulation, lipid traffic...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765572/ https://www.ncbi.nlm.nih.gov/pubmed/33339212 http://dx.doi.org/10.3390/ijms21249587 |
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author | Sun, Yi Ding, Shuzhe |
author_facet | Sun, Yi Ding, Shuzhe |
author_sort | Sun, Yi |
collection | PubMed |
description | The endoplasmic reticulum (ER) makes physical contacts with mitochondria at specific sites, and the hubs between the two organelles are called mitochondria-associated ER membranes (MAMs). MAMs are known to play key roles in biological processes, such as intracellular Ca(2+) regulation, lipid trafficking, and metabolism, as well as cell death, etc. Studies demonstrated that dysregulation of MAMs significantly contributed to insulin resistance. Alterations of MAMs’ juxtaposition and integrity, impaired expressions of insulin signaling molecules, disruption of Ca(2+) homeostasis, and compromised metabolic flexibility are all actively involved in the above processes. In addition, exercise training is considered as an effective stimulus to ameliorate insulin resistance. Although the underlying mechanisms for exercise-induced improvement in insulin resistance are not fully understood, MAMs may be critical for the beneficial effects of exercise. |
format | Online Article Text |
id | pubmed-7765572 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77655722020-12-27 ER–Mitochondria Contacts and Insulin Resistance Modulation through Exercise Intervention Sun, Yi Ding, Shuzhe Int J Mol Sci Review The endoplasmic reticulum (ER) makes physical contacts with mitochondria at specific sites, and the hubs between the two organelles are called mitochondria-associated ER membranes (MAMs). MAMs are known to play key roles in biological processes, such as intracellular Ca(2+) regulation, lipid trafficking, and metabolism, as well as cell death, etc. Studies demonstrated that dysregulation of MAMs significantly contributed to insulin resistance. Alterations of MAMs’ juxtaposition and integrity, impaired expressions of insulin signaling molecules, disruption of Ca(2+) homeostasis, and compromised metabolic flexibility are all actively involved in the above processes. In addition, exercise training is considered as an effective stimulus to ameliorate insulin resistance. Although the underlying mechanisms for exercise-induced improvement in insulin resistance are not fully understood, MAMs may be critical for the beneficial effects of exercise. MDPI 2020-12-16 /pmc/articles/PMC7765572/ /pubmed/33339212 http://dx.doi.org/10.3390/ijms21249587 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sun, Yi Ding, Shuzhe ER–Mitochondria Contacts and Insulin Resistance Modulation through Exercise Intervention |
title | ER–Mitochondria Contacts and Insulin Resistance Modulation through Exercise Intervention |
title_full | ER–Mitochondria Contacts and Insulin Resistance Modulation through Exercise Intervention |
title_fullStr | ER–Mitochondria Contacts and Insulin Resistance Modulation through Exercise Intervention |
title_full_unstemmed | ER–Mitochondria Contacts and Insulin Resistance Modulation through Exercise Intervention |
title_short | ER–Mitochondria Contacts and Insulin Resistance Modulation through Exercise Intervention |
title_sort | er–mitochondria contacts and insulin resistance modulation through exercise intervention |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765572/ https://www.ncbi.nlm.nih.gov/pubmed/33339212 http://dx.doi.org/10.3390/ijms21249587 |
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