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11βHSD1 Inhibition with AZD4017 Improves Lipid Profiles and Lean Muscle Mass in Idiopathic Intracranial Hypertension

BACKGROUND: The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) determines prereceptor metabolism and activation of glucocorticoids within peripheral tissues. Its dysregulation has been implicated in a wide array of metabolic diseases, leading to the development of selective 11β-HSD1 inhib...

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Detalles Bibliográficos
Autores principales:	Hardy, Rowan S, Botfield, Hannah, Markey, Keira, Mitchell, James L, Alimajstorovic, Zerin, Westgate, Connar S J, Sagmeister, Michael, Fairclough, Rebecca J, Ottridge, Ryan S, Yiangou, Andreas, Storbeck, Karl-Heinz H, Taylor, Angela E, Gilligan, Lorna C, Arlt, Wiebke, Stewart, Paul M, Tomlinson, Jeremy W, Mollan, Susan P, Lavery, Gareth G, Sinclair, Alexandra J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Clinical Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765633/ https://www.ncbi.nlm.nih.gov/pubmed/33098644 http://dx.doi.org/10.1210/clinem/dgaa766

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