Cargando…

GSK3α: An Important Paralog in Neurodegenerative Disorders and Cancer

The biological activity of the enzyme glycogen synthase kinase-3 (GSK3) is fulfilled by two paralogs named GSK3α and GSK3β, which possess both redundancy and specific functions. The upregulated activity of these proteins is linked to the development of disorders such as neurodegenerative disorders (...

Descripción completa

Detalles Bibliográficos
Autores principales:	Silva-García, Octavio, Cortés-Vieyra, Ricarda, Mendoza-Ambrosio, Francisco N., Ramírez-Galicia, Guillermo, Baizabal-Aguirre, Víctor M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765659/ https://www.ncbi.nlm.nih.gov/pubmed/33339170 http://dx.doi.org/10.3390/biom10121683

Ejemplares similares

The Glycogen Synthase Kinase 3α and β Isoforms Differentially Regulates Interleukin-12p40 Expression in Endothelial Cells Stimulated with Peptidoglycan from Staphylococcus aureus
por: Cortés-Vieyra, Ricarda, et al.
Publicado: (2015)

Glycogen Synthase Kinase 3β Modulates the Inflammatory Response Activated by Bacteria, Viruses, and Parasites
por: Cortés-Vieyra, Ricarda, et al.
Publicado: (2021)

Elucidation of the GSK3α Structure Informs the Design of Novel, Paralog-Selective Inhibitors
por: Amaral, Brenda, et al.
Publicado: (2023)

Role of glycogen synthase kinase-3 beta in the inflammatory response caused by bacterial pathogens
por: Cortés-Vieyra, Ricarda, et al.
Publicado: (2012)

Behavior of Eosinophil Counts in Recovered and Deceased COVID-19 Patients over the Course of the Disease
por: Cortés-Vieyra, Ricarda, et al.
Publicado: (2021)

Peptide IDR-1002 Inhibits NF-κB Nuclear Translocation by Inhibition of IκBα Degradation and Activates p38/ERK1/2–MSK1-Dependent CREB Phosphorylation in Macrophages Stimulated with Lipopolysaccharide
por: Huante-Mendoza, Alejandro, et al.
Publicado: (2016)

GSK-3 in Neurodegenerative Diseases
por: Lei, Peng, et al.
Publicado: (2011)

The Wnt/β-Catenin Signaling Pathway Controls the Inflammatory Response in Infections Caused by Pathogenic Bacteria
por: Silva-García, Octavio, et al.
Publicado: (2014)

Wnt/β-Catenin Signaling as a Molecular Target by Pathogenic Bacteria
por: Silva-García, Octavio, et al.
Publicado: (2019)

Expression patterns of dscam and sdk gene paralogs in developing zebrafish retina
por: Galicia, Carlos A., et al.
Publicado: (2018)

Glycogen Synthase Kinase 3α Is the Main Isoform That Regulates the Transcription Factors Nuclear Factor-Kappa B and cAMP Response Element Binding in Bovine Endothelial Cells Infected with Staphylococcus aureus
por: Silva-García, Octavio, et al.
Publicado: (2018)

Neutrophil Functions in Periodontal Homeostasis
por: Cortés-Vieyra, Ricarda, et al.
Publicado: (2016)

Podocyte GSK3α is important for autophagy and its loss detrimental for glomerular function
por: Hurcombe, Jennifer A., et al.
Publicado: (2019)

Editorial: Cross-Talk Mechanisms of Wnt/Beta-Catenin Signaling Components with TLR-Activated Signaling Molecules in the Inflammatory Response
por: Baizabal-Aguirre, Víctor M.
Publicado: (2017)

Novel Reporter Alleles of GSK-3α and GSK-3β
por: Barrell, William B., et al.
Publicado: (2012)

Revisiting the Proposition of Binding Pockets and Bioactive Poses for GSK-3β Allosteric Modulators Addressed to Neurodegenerative Diseases
por: Silva, Guilherme M., et al.
Publicado: (2021)

GSK-3β, FYN, and DYRK1A: Master Regulators in Neurodegenerative Pathways
por: Demuro, Stefania, et al.
Publicado: (2021)

Complex fate of paralogs
por: Szklarczyk, Radek, et al.
Publicado: (2008)

Examining the Toxicity of α-Synuclein in Neurodegenerative Disorders
por: Shan, Frank Y., et al.
Publicado: (2021)

Mutations in the paralogous human α-globin genes yielding identical hemoglobin variants
por: Moradkhani, Kamran, et al.
Publicado: (2008)

Structural Plasticity of Dendritic Spines Requires GSK3α and GSK3β
por: Cymerman, Iwona A., et al.
Publicado: (2015)

GSK3α and GSK3β Phosphorylate Arc and Regulate its Degradation
por: Gozdz, Agata, et al.
Publicado: (2017)

Characterization of paralogous protein families in rice
por: Lin, Haining, et al.
Publicado: (2008)

Paralog Explorer: A resource for mining information about paralogs in common research organisms
por: Hu, Yanhui, et al.
Publicado: (2022)

Opposing Roles of GSK3α and GSK3β Phosphorylation in Platelet Function and Thrombosis
por: Moore, Samantha F., et al.
Publicado: (2021)

Estradiol Activates PI3K/Akt/GSK3 Pathway Under Chronic Neurodegenerative Conditions Triggered by Perinatal Asphyxia
por: Saraceno, G. Ezequiel, et al.
Publicado: (2018)

Differential Use of Human Neutrophil Fcγ Receptors for Inducing Neutrophil Extracellular Trap Formation
por: Alemán, Omar Rafael, et al.
Publicado: (2016)

Transforming Growth Factor-β-Activated Kinase 1 Is Required for Human FcγRIIIb-Induced Neutrophil Extracellular Trap Formation
por: Alemán, Omar Rafael, et al.
Publicado: (2016)

A tRNA methyltransferase paralog is important for ribosome stability and cell division in Trypanosoma brucei
por: Fleming, Ian M. C., et al.
Publicado: (2016)

CSPα in neurodegenerative diseases
por: Huang, Liqin, et al.
Publicado: (2022)

The Importance of Tau Phosphorylation for Neurodegenerative Diseases
por: Noble, Wendy, et al.
Publicado: (2013)

GSK-3α Is a Novel Target of CREB and CREB-GSK-3α Signaling Participates in Cell Viability in Lung Cancer
por: Park, Sin-Aye, et al.
Publicado: (2016)

Discrete functions of GSK3α and GSK3β isoforms in prostate tumor growth and micrometastasis
por: Gao, Fei, et al.
Publicado: (2015)

Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection
por: Steele, Lynette, et al.
Publicado: (2021)

CLIPing the brain: Studies of protein–RNA interactions important for neurodegenerative disorders()()
por: Modic, Miha, et al.
Publicado: (2013)

Interaction between α-Synuclein and Other Proteins in Neurodegenerative Disorders
por: Jellinger, Kurt A.
Publicado: (2011)

Lipid and Lipid Raft Alteration in Aging and Neurodegenerative Diseases: A Window for the Development of New Biomarkers
por: Mesa-Herrera, Fátima, et al.
Publicado: (2019)

OPTIC: orthologous and paralogous transcripts in clades
por: Heger, Andreas, et al.
Publicado: (2008)

Evolution of MIR168 paralogs in Brassicaceae
por: Gazzani, Silvia, et al.
Publicado: (2009)

Orthology and paralogy constraints: satisfiability and consistency
por: Lafond, Manuel, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_5co1isnnm7j2ih9bupgc1u0urb