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Association of Primary Sjögren’s Syndrome and Vitamin B12 Deficiency: A Cross-Sectional Case-Control Study

Descriptive and retrospective studies without control groups have suggested a possible association between primary Sjögren’s syndrome (pSS) and vitamin B12 (B12) deficiency. This is of importance because several mucosal and neurological features are common to these two conditions and could be preven...

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Autores principales: Urbanski, Geoffrey, Chabrun, Floris, Schaepelynck, Baudouin, May, Morgane, Loiseau, Marianne, Schlumberger, Esther, Delattre, Estelle, Lavigne, Christian, Lacombe, Valentin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765802/
https://www.ncbi.nlm.nih.gov/pubmed/33339380
http://dx.doi.org/10.3390/jcm9124063
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author Urbanski, Geoffrey
Chabrun, Floris
Schaepelynck, Baudouin
May, Morgane
Loiseau, Marianne
Schlumberger, Esther
Delattre, Estelle
Lavigne, Christian
Lacombe, Valentin
author_facet Urbanski, Geoffrey
Chabrun, Floris
Schaepelynck, Baudouin
May, Morgane
Loiseau, Marianne
Schlumberger, Esther
Delattre, Estelle
Lavigne, Christian
Lacombe, Valentin
author_sort Urbanski, Geoffrey
collection PubMed
description Descriptive and retrospective studies without control groups have suggested a possible association between primary Sjögren’s syndrome (pSS) and vitamin B12 (B12) deficiency. This is of importance because several mucosal and neurological features are common to these two conditions and could be prevented or reversed in case of B12 deficiency. We aimed to evaluate the association between pSS and B12 deficiency. We prospectively assessed the B12 status of 490 patients hospitalized in an internal medicine department over a 15-week period. Patients with pernicious anemia were excluded. We extracted patients with pSS and paired them with controls according to age and sex, with a 1:5 ratio. Twenty-one pSS patients were paired with 105 control patients. The median age was 70 years old (51–75) and 95.2% of patients were women. The plasma B12 level was lower in pSS patients (329 (293–521) ng/L vs. 456 (341–587) ng/L, p < 0.0001). B12 deficiency was associated with pSS (42.9% among pSS patients vs. 11.4% among controls), even after adjustment for other causes of B12 deficiency (OR 6.45 (95%CI: 2.08–20.0)). In conclusion, pSS appeared to be associated with B12 deficiency, even after the exclusion of pernicious anemia. This justifies screening and treating B12 deficiency in pSS patients.
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spelling pubmed-77658022020-12-28 Association of Primary Sjögren’s Syndrome and Vitamin B12 Deficiency: A Cross-Sectional Case-Control Study Urbanski, Geoffrey Chabrun, Floris Schaepelynck, Baudouin May, Morgane Loiseau, Marianne Schlumberger, Esther Delattre, Estelle Lavigne, Christian Lacombe, Valentin J Clin Med Article Descriptive and retrospective studies without control groups have suggested a possible association between primary Sjögren’s syndrome (pSS) and vitamin B12 (B12) deficiency. This is of importance because several mucosal and neurological features are common to these two conditions and could be prevented or reversed in case of B12 deficiency. We aimed to evaluate the association between pSS and B12 deficiency. We prospectively assessed the B12 status of 490 patients hospitalized in an internal medicine department over a 15-week period. Patients with pernicious anemia were excluded. We extracted patients with pSS and paired them with controls according to age and sex, with a 1:5 ratio. Twenty-one pSS patients were paired with 105 control patients. The median age was 70 years old (51–75) and 95.2% of patients were women. The plasma B12 level was lower in pSS patients (329 (293–521) ng/L vs. 456 (341–587) ng/L, p < 0.0001). B12 deficiency was associated with pSS (42.9% among pSS patients vs. 11.4% among controls), even after adjustment for other causes of B12 deficiency (OR 6.45 (95%CI: 2.08–20.0)). In conclusion, pSS appeared to be associated with B12 deficiency, even after the exclusion of pernicious anemia. This justifies screening and treating B12 deficiency in pSS patients. MDPI 2020-12-16 /pmc/articles/PMC7765802/ /pubmed/33339380 http://dx.doi.org/10.3390/jcm9124063 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Urbanski, Geoffrey
Chabrun, Floris
Schaepelynck, Baudouin
May, Morgane
Loiseau, Marianne
Schlumberger, Esther
Delattre, Estelle
Lavigne, Christian
Lacombe, Valentin
Association of Primary Sjögren’s Syndrome and Vitamin B12 Deficiency: A Cross-Sectional Case-Control Study
title Association of Primary Sjögren’s Syndrome and Vitamin B12 Deficiency: A Cross-Sectional Case-Control Study
title_full Association of Primary Sjögren’s Syndrome and Vitamin B12 Deficiency: A Cross-Sectional Case-Control Study
title_fullStr Association of Primary Sjögren’s Syndrome and Vitamin B12 Deficiency: A Cross-Sectional Case-Control Study
title_full_unstemmed Association of Primary Sjögren’s Syndrome and Vitamin B12 Deficiency: A Cross-Sectional Case-Control Study
title_short Association of Primary Sjögren’s Syndrome and Vitamin B12 Deficiency: A Cross-Sectional Case-Control Study
title_sort association of primary sjögren’s syndrome and vitamin b12 deficiency: a cross-sectional case-control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765802/
https://www.ncbi.nlm.nih.gov/pubmed/33339380
http://dx.doi.org/10.3390/jcm9124063
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