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Relationship between Soluble (Pro)Renin Receptor and Renin Activity in Patients with Severe Heart Failure

The (pro)renin receptor ((P)RR), which evokes renin activity with prorenin, is secreted extracellularly as soluble (P)RR (s(P)RR) and may participate in tissue renin-angiotensin system (RAS) activity in severe heart failure (HF) patients. The aim of this study was to determine whether s(P)RR is an a...

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Autores principales: Ikeda, Yoshifumi, Tsutsui, Kenta, Yamada, Yoshihiro, Kato, Ritsushi, Muramatsu, Toshihiro, Senbonmatsu, Takaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765833/
https://www.ncbi.nlm.nih.gov/pubmed/33352807
http://dx.doi.org/10.3390/jcm9124110
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author Ikeda, Yoshifumi
Tsutsui, Kenta
Yamada, Yoshihiro
Kato, Ritsushi
Muramatsu, Toshihiro
Senbonmatsu, Takaaki
author_facet Ikeda, Yoshifumi
Tsutsui, Kenta
Yamada, Yoshihiro
Kato, Ritsushi
Muramatsu, Toshihiro
Senbonmatsu, Takaaki
author_sort Ikeda, Yoshifumi
collection PubMed
description The (pro)renin receptor ((P)RR), which evokes renin activity with prorenin, is secreted extracellularly as soluble (P)RR (s(P)RR) and may participate in tissue renin-angiotensin system (RAS) activity in severe heart failure (HF) patients. The aim of this study was to determine whether s(P)RR is an adequate marker in severe HF patients treated with RAS inhibitors, beta-blockers, and tolvaptan. We enrolled 11 patients with severe HF between May 2013 and June 2014. First of all, furosemide of all patients was changed to tolvaptan with hydrochlorothiazide and then the treatment had been changed according to the patient’s condition. After 1, 3, 6, and 12 months, the variance of s(P)RR, plasma renin activity (PRA), plasma renin concentration (PRC), brain natriuretic peptide (BNP) and their association was investigated. Furosemide was restarted in five patients and two patients suffered cardiac death. PRA/PRC and s(P)RR were unchanged (PRA: 10.7 ± 13.9 to 12.8 ± 8.5 ng/mL/h; PRC: 347.1 ± 577.5 to 148.3 ± 123.8 pg/mL; s(P)RR: 28.2 ± 19.3 to 33.4 ± 22.4 ng/mL) and had no significant correlations (PRA and s(P)RR: p = 0.36; PRC and s(P)RR: p = 0.35). There was a significant positive correlation with a high correlation coefficient (CC) between PRA and PRC (p < 0.0001, CC = 0.76), and a negative correlation with weak CC between BNP and s(P)RR (p = 0.01, CC = −0.45). In conclusion, s(P)RR was always high and had no correlations with disease state and PRA/PRC in severe HF patients.
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spelling pubmed-77658332020-12-28 Relationship between Soluble (Pro)Renin Receptor and Renin Activity in Patients with Severe Heart Failure Ikeda, Yoshifumi Tsutsui, Kenta Yamada, Yoshihiro Kato, Ritsushi Muramatsu, Toshihiro Senbonmatsu, Takaaki J Clin Med Article The (pro)renin receptor ((P)RR), which evokes renin activity with prorenin, is secreted extracellularly as soluble (P)RR (s(P)RR) and may participate in tissue renin-angiotensin system (RAS) activity in severe heart failure (HF) patients. The aim of this study was to determine whether s(P)RR is an adequate marker in severe HF patients treated with RAS inhibitors, beta-blockers, and tolvaptan. We enrolled 11 patients with severe HF between May 2013 and June 2014. First of all, furosemide of all patients was changed to tolvaptan with hydrochlorothiazide and then the treatment had been changed according to the patient’s condition. After 1, 3, 6, and 12 months, the variance of s(P)RR, plasma renin activity (PRA), plasma renin concentration (PRC), brain natriuretic peptide (BNP) and their association was investigated. Furosemide was restarted in five patients and two patients suffered cardiac death. PRA/PRC and s(P)RR were unchanged (PRA: 10.7 ± 13.9 to 12.8 ± 8.5 ng/mL/h; PRC: 347.1 ± 577.5 to 148.3 ± 123.8 pg/mL; s(P)RR: 28.2 ± 19.3 to 33.4 ± 22.4 ng/mL) and had no significant correlations (PRA and s(P)RR: p = 0.36; PRC and s(P)RR: p = 0.35). There was a significant positive correlation with a high correlation coefficient (CC) between PRA and PRC (p < 0.0001, CC = 0.76), and a negative correlation with weak CC between BNP and s(P)RR (p = 0.01, CC = −0.45). In conclusion, s(P)RR was always high and had no correlations with disease state and PRA/PRC in severe HF patients. MDPI 2020-12-19 /pmc/articles/PMC7765833/ /pubmed/33352807 http://dx.doi.org/10.3390/jcm9124110 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ikeda, Yoshifumi
Tsutsui, Kenta
Yamada, Yoshihiro
Kato, Ritsushi
Muramatsu, Toshihiro
Senbonmatsu, Takaaki
Relationship between Soluble (Pro)Renin Receptor and Renin Activity in Patients with Severe Heart Failure
title Relationship between Soluble (Pro)Renin Receptor and Renin Activity in Patients with Severe Heart Failure
title_full Relationship between Soluble (Pro)Renin Receptor and Renin Activity in Patients with Severe Heart Failure
title_fullStr Relationship between Soluble (Pro)Renin Receptor and Renin Activity in Patients with Severe Heart Failure
title_full_unstemmed Relationship between Soluble (Pro)Renin Receptor and Renin Activity in Patients with Severe Heart Failure
title_short Relationship between Soluble (Pro)Renin Receptor and Renin Activity in Patients with Severe Heart Failure
title_sort relationship between soluble (pro)renin receptor and renin activity in patients with severe heart failure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765833/
https://www.ncbi.nlm.nih.gov/pubmed/33352807
http://dx.doi.org/10.3390/jcm9124110
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