Sterically Facilitated Intramolecular Nucleophilic NMe(2) Group Substitution in the Synthesis of Fused Isoxazoles: Theoretical Study

The influence of steric repulsion between the NMe(2) group and a second ortho-(peri-)substituent in the series of 1-dimethylaminonaphthalene and N,N-dimethylanilene ortho-oximes on the ease of the NMe(2) group’s intramolecular nucleophilic substitution is studied. Possible reaction intermediates for...

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Detalles Bibliográficos
Autores principales: Antonov, Alexander S., Tupikina, Elena Yu, Karpov, Valerii V., Mulloyarova, Valeriia V., Bardakov, Victor G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765840/
https://www.ncbi.nlm.nih.gov/pubmed/33348591
http://dx.doi.org/10.3390/molecules25245977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765840/
https://www.ncbi.nlm.nih.gov/pubmed/33348591
http://dx.doi.org/10.3390/molecules25245977

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