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Patients with Single-Ventricle Physiology over the Age of 40 Years
Background: Single-ventricle physiology (SVP) is associated with significant morbidity and mortality at a young age. However, survival prospects have improved and risk factors for a negative outcome are well described in younger cohorts. Data regarding older adults is scarce. Methods: In this study,...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765901/ https://www.ncbi.nlm.nih.gov/pubmed/33352831 http://dx.doi.org/10.3390/jcm9124085 |
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author | Pujol, Claudia Schiele, Sandra Maurer, Susanne J. Hock, Julia Fritz, Celina Hager, Alfred Ewert, Peter Tutarel, Oktay |
author_facet | Pujol, Claudia Schiele, Sandra Maurer, Susanne J. Hock, Julia Fritz, Celina Hager, Alfred Ewert, Peter Tutarel, Oktay |
author_sort | Pujol, Claudia |
collection | PubMed |
description | Background: Single-ventricle physiology (SVP) is associated with significant morbidity and mortality at a young age. However, survival prospects have improved and risk factors for a negative outcome are well described in younger cohorts. Data regarding older adults is scarce. Methods: In this study, SVP patients under active follow-up at our center who were ≥40 years of age at any point between January 2005 and December 2018 were included. Demographic data, as well as medical/surgical history were retrieved from hospital records. The primary end-point was all-cause mortality. Results: Altogether, 49 patients (19 female (38.8%), mean age 49.2 ± 6.4 years) were included. Median follow-up time was 4.9 years (interquartile range (IQR): 1.8–8.5). Of these patients, 40 (81.6%) had undergone at least one cardiac surgery. The most common extracardiac comorbidities were thyroid dysfunction (n = 27, 55.1%) and renal disease (n = 15, 30.6%). During follow-up, 10 patients (20.4%) died. On univariate analysis, renal disease and liver cirrhosis were predictors of all-cause mortality. On multivariate analysis, only renal disease (hazard ratio (HR): 12.5, 95% confidence interval (CI): 1.5–106.3, p = 0.021) remained as an independent predictor. Conclusions: SVP patients ≥40 years of age are burdened with significant morbidity and mortality. Renal disease is an independent predictor of all-cause mortality. |
format | Online Article Text |
id | pubmed-7765901 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77659012020-12-28 Patients with Single-Ventricle Physiology over the Age of 40 Years Pujol, Claudia Schiele, Sandra Maurer, Susanne J. Hock, Julia Fritz, Celina Hager, Alfred Ewert, Peter Tutarel, Oktay J Clin Med Article Background: Single-ventricle physiology (SVP) is associated with significant morbidity and mortality at a young age. However, survival prospects have improved and risk factors for a negative outcome are well described in younger cohorts. Data regarding older adults is scarce. Methods: In this study, SVP patients under active follow-up at our center who were ≥40 years of age at any point between January 2005 and December 2018 were included. Demographic data, as well as medical/surgical history were retrieved from hospital records. The primary end-point was all-cause mortality. Results: Altogether, 49 patients (19 female (38.8%), mean age 49.2 ± 6.4 years) were included. Median follow-up time was 4.9 years (interquartile range (IQR): 1.8–8.5). Of these patients, 40 (81.6%) had undergone at least one cardiac surgery. The most common extracardiac comorbidities were thyroid dysfunction (n = 27, 55.1%) and renal disease (n = 15, 30.6%). During follow-up, 10 patients (20.4%) died. On univariate analysis, renal disease and liver cirrhosis were predictors of all-cause mortality. On multivariate analysis, only renal disease (hazard ratio (HR): 12.5, 95% confidence interval (CI): 1.5–106.3, p = 0.021) remained as an independent predictor. Conclusions: SVP patients ≥40 years of age are burdened with significant morbidity and mortality. Renal disease is an independent predictor of all-cause mortality. MDPI 2020-12-18 /pmc/articles/PMC7765901/ /pubmed/33352831 http://dx.doi.org/10.3390/jcm9124085 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pujol, Claudia Schiele, Sandra Maurer, Susanne J. Hock, Julia Fritz, Celina Hager, Alfred Ewert, Peter Tutarel, Oktay Patients with Single-Ventricle Physiology over the Age of 40 Years |
title | Patients with Single-Ventricle Physiology over the Age of 40 Years |
title_full | Patients with Single-Ventricle Physiology over the Age of 40 Years |
title_fullStr | Patients with Single-Ventricle Physiology over the Age of 40 Years |
title_full_unstemmed | Patients with Single-Ventricle Physiology over the Age of 40 Years |
title_short | Patients with Single-Ventricle Physiology over the Age of 40 Years |
title_sort | patients with single-ventricle physiology over the age of 40 years |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765901/ https://www.ncbi.nlm.nih.gov/pubmed/33352831 http://dx.doi.org/10.3390/jcm9124085 |
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